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Shao-Hsien Liu PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentPopulation and Quantitative Health Sciences
AddressUMass Chan Medical School
368 Plantation Street AS7-1071
Worcester MA 01608
Phone774-455-3616
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionRheumatology

    InstitutionT.H. Chan School of Medicine
    DepartmentPopulation and Quantitative Health Sciences
    DivisionEpidemiology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPopulation Health Sciences


    Collapse Biography 
    Collapse education and training
    National Yang-Ming College of Medicine, Taipei City, , TaiwanBSPhysical Therapy
    Emory University, Atlanta, GA, United StatesMPH
    University of Massachusetts Medical School, Worcester, MA, United StatesPHDClinical & Population Health

    Collapse Overview 
    Collapse overview

    Dr. Liu is a musculoskeletal epidemiologist with years of clinical practice as a physical therapist. Dr. Liu's research focus includes the application of advanced epidemiological and statistical methods to generate knowledge to ultimately improve quality of care for patients with inflammatory arthritis. Dr. Liu has extensive experience using nationally representative samples with complex, multistage designs and observational data with measurements of patient-reported outcomes and physical activity. One of his current projects is to evaluate the care received post discharge from joint replacement surgery, the impact on the caregivers, and the extent to which this differs by race/ethnicity. He is also conducting a study to address the root causes that drive sex- and gender-differences in reporting health quality of life among patients axial spondyloarthritis. Dr. Liu mentors doctoral students and teaches epidemiologic courses including CTS 604: Comprehensive Project.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nunes AP, Jung H, Yuan Y, Baek J, Pawasauskas J, Hume AL, Liu SH, Lapane KL. Comparative Safety of Short-Acting Opioid Dose Escalation and Long-Acting Opioid Initiation in Nursing Home Residents. J Am Geriatr Soc. 2025 Mar 28. PMID: 40152203.
      Citations:    
    2. Chekmeyan M, Liu SH. Artificial intelligence for the diagnosis of pediatric appendicitis: A systematic review. Am J Emerg Med. 2025 Feb 17; 92:18-31. PMID: 40048888.
      Citations:    
    3. Driban JB, Baek J, Patarini JC, Kirillov E, Vo N, Richard MJ, Zhang M, Harkey MS, Lo GH, Liu SH, Eaton CB, MacKay J, Barbe MF, McAlindon TE. Contralateral knee osteoarthritis severity relates to magnetic resonance imaging findings in knees with and without osteoarthritis: Data from the osteoarthritis initiative. Osteoarthr Cartil Open. 2025 Jun; 7(2):100585. PMID: 40093663.
      Citations:    
    4. Liu SH, Kay J. Disparities in Diagnosis: A Call for Equity in Radiographic Axial Spondyloarthritis Care. J Rheumatol. 2025 Feb 15. PMID: 39955094.
      Citations:    
    5. Fromm MK, Liu SH, Carr C, Stefancic E, Rogalski M. Factors associated with improved outcomes after lumbar transforaminal epidural steroid injections for radicular pain: A systematic review. N Am Spine Soc J. 2025 Mar; 21:100592. PMID: 40065830.
      Citations:    
    6. Zhu Y, Liu SH , Alam MAU . Wearable-based Fair and Accurate Pain Assessment Using Multi-Attribute Fairness Loss in Convolutional Neural Networks. 21st EAI International Conference on Mobile and Ubiquitous Systems: Computing, Networking and Services, MobiQuitous 2024. 2024.
    7. Nunes AP, Yuan Y, Baek J, Pawasauskas J, Hume AL, Liu SH, Lapane KL. Effectiveness of Short-Acting Opioid Escalation vs Initiation of a Long-Acting Opioid in Nursing Home Residents. J Am Med Dir Assoc. 2024 Sep; 25(9):105077. PMID: 38862100.
      Citations:    
    8. Parhar D, Dhatt R, Liu SH, Slater A, Liu L, Khan N, Badii M, Masri B, Liu DM. Advances in Interventional Radiology Technology for the Treatment of Knee Osteoarthritis. Orthop Clin North Am. 2024 Oct; 55(4):435-443. PMID: 39216948.
      Citations:    
    9. Shridharmurthy D, Lapane KL, Baek J, Nunes AP, Weisman MH, Kay J, Liu SH. Sex Differences in Time to Initiate Nonsteroidal Anti-Inflammatory Drugs or Biologic Disease-Modifying Antirheumatic Drugs Among Patients With Axial Spondyloarthritis. Arthritis Care Res (Hoboken). 2024 08; 76(8):1149-1161. PMID: 38538532.
      Citations:    
    10. Zheng H, Ash AS, Yang W, Liu SH, Allison J, Ayers DC. Strengthening Quality Measurement to Predict Success for Total Knee Arthroplasty: Results from a Nationally Representative Total Knee Arthroplasty Cohort. J Bone Joint Surg Am. 2024 Apr 17; 106(8):708-715. PMID: 38271493.
      Citations:    Fields:    
    11. Oyinbo AG, Epstein MM, Sabatino MJ, Liu SH, Person SD, Baek J, Alcusky MD, Lapane KL. Association of the affordable care act with perceived health care quality of cancer survivors. Cancer Epidemiol. 2023 Oct 27; 87:102483. PMID: 39492177.
      Citations:    
    12. Liu SH, Yuan Y, Baek J, Nunes AP, Pawasauskas J, Hume AL, Lapane KL. Comparative safety of adding serotonin and norepinephrine reuptake inhibitors (SNRIs) versus nonsteroidal anti-inflammatory drugs (NSAIDs) to short-acting opioids for non-malignant pain in nursing homes. J Am Geriatr Soc. 2023 11; 71(11):3390-3402. PMID: 37530560.
      Citations:    Fields:    Translation:Humans
    13. Shridharmurthy D, Lapane KL, Nunes AP, Baek J, Weisman MH, Kay J, Liu SH. Postpartum Depression in Reproductive-Age Women With and Without Rheumatic Disease: A Population-Based Matched Cohort Study. J Rheumatol. 2023 10; 50(10):1287-1295. PMID: 37399461.
      Citations:    Fields:    Translation:Humans
    14. Osundolire S, Mbrah A, Liu SH, Lapane KL. Association Between Patient and Facility Characteristics and Rehabilitation Outcomes After Joint Replacement Surgery in Different Rehabilitation Settings for Older Adults: A Systematic Review. J Geriatr Phys Ther. 2024 Jan-Mar 01; 47(1):E1-E18. PMID: 36598848.
      Citations:    Fields:    Translation:Humans
    15. Shridharmurthy D, Lapane KL, Baek J, Nunes A, Kay J, Liu SH. Comanagement with rheumatology and prescription biologics filled during pregnancy in women with rheumatic diseases: a retrospective analysis of US administrative claims data. BMJ Open. 2022 12 22; 12(12):e065189. PMID: 36549721.
      Citations:    Fields:    
    16. Stovall R, van der Horst-Bruinsma IE, Liu SH, Rusman T, Gensler LS. Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis. Nat Rev Rheumatol. 2022 11; 18(11):657-669. PMID: 36109666.
      Citations: 7     Fields:    Translation:Humans
    17. Shridharmurthy D, Lapane KL, Khan S, Yi E, Baek J, Kay J, Liu SH. Development and test-retest reliability of a screening tool for axial spondyloarthritis. PLoS One. 2022; 17(7):e0269494. PMID: 35802613.
      Citations: 1     Fields:    Translation:Humans
    18. Yuan Y, Lapane KL, Tjia J, Baek J, Liu SH, Ulbricht CM. Trajectories of physical frailty and cognitive impairment in older adults in United States nursing homes. BMC Geriatr. 2022 04 19; 22(1):339. PMID: 35439970.
      Citations: 4     Fields:    Translation:Humans
    19. Shridharmurthy D, Khan S, Lapane KL, Yi E, Kay J, Liu SH. Development of a screening tool to identify patients with axial spondyloarthritis: a cognitive interview study. Clin Rheumatol. 2022 May; 41(5):1391-1402. PMID: 35059882.
      Citations: 1     Fields:    Translation:Humans
    20. Khan S, Shridharmurthy D, Lapane KL, Dube C, Kay J, Yi E, Liu SH. The disease burden of axial spondyloarthritis: through a gendered lens. Clin Rheumatol. 2022 Apr; 41(4):1115-1124. PMID: 34988682.
      Citations: 2     Fields:    Translation:Humans
    21. Lapane KL, Dub? C, Ferrucci K, Khan S, Kuhn KA, Yi E, Kay J, Liu SH. Patient perspectives on health care provider practices leading to an axial spondyloarthritis diagnosis: an exploratory qualitative research study. BMC Fam Pract. 2021 12 20; 22(1):251. PMID: 34930136.
      Citations: 2     Fields:    Translation:Humans
    22. Hoque S, Goulding M, Hazeltine M, Ferrucci KA, Trivedi M, Liu SH. Caregiver-perceived neighborhood safety and pediatric asthma severity: 2017-2018 National Survey of Children's Health. Pediatr Pulmonol. 2022 02; 57(2):376-385. PMID: 34796705.
      Citations: 1     Fields:    Translation:Humans
    23. Yuan Y, Lapane KL, Tjia J, Baek J, Liu SH, Ulbricht CM. Physical frailty and cognitive impairment in older nursing home residents: a latent class analysis. BMC Geriatr. 2021 09 07; 21(1):487. PMID: 34493211.
      Citations: 5     Fields:    Translation:Humans
    24. Dube CE, Lapane KL, Ferrucci KA, Beccia AL, Khan SK, Yi E, Kay J, Kuhn KA, Ogdie A, Liu SH. Personal Experiences with Diagnostic Delay Among Axial Spondyloarthritis Patients: A Qualitative Study. Rheumatol Ther. 2021 Jun; 8(2):1015-1030. PMID: 34059989.
      Citations:    
    25. Lapane KL, Shridharmurthy D, Khan S, Lindstrom D, Beccia A, Yi E, Kay J, Dube C, Liu SH. Primary care physician perspectives on screening for axial spondyloarthritis: A qualitative study. PLoS One. 2021; 16(5):e0252018. PMID: 34029339.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    26. Yuan Y, Lapane KL, Tjia J, Baek J, Liu SH, Ulbricht CM. Physical Frailty and Cognitive Impairment in Older Adults in United States Nursing Homes. Dement Geriatr Cogn Disord. 2021; 50(1):60-67. PMID: 33887723.
      Citations: 11     Fields:    Translation:Humans
    27. Shridharmurthy D, Zhao D, Lapane KL, Baek J, Kay J, Liu SH. Disease Burden and Health-Related Quality of Life Among Women and Men with Spondyloarthritis: An Exploratory Analysis of a Population-Based Sample. J Womens Health (Larchmt). 2021 11; 30(11):1637-1644. PMID: 33450162.
      Citations:    Fields:    Translation:Humans
    28. Lapane KL, Shridharmurthy D, Harkey MS, Driban JB, Dub? CE, Liu SH. The relationship between restless sleep and symptoms of the knee: data from the Osteoarthritis Initiative. Clin Rheumatol. 2021 Jun; 40(6):2167-2175. PMID: 33411138.
      Citations: 1     Fields:    Translation:Humans
    29. Dube CE, Morrison RA, Mack DS, Jesdale BM, Nunes AP, Liu SH, Lapane KL. Prevalence of Pain on Admission by Level of Cognitive Impairment in Nursing Homes. J Pain Res. 2020; 13:2663-2672. PMID: 33116808.
      Citations:    
    30. Liu SH, Shridharmurthy D, Lapane KL, Dub? CE, Gravallese EM, Kay J. Physical Activity and Attitudes Toward Exercise in People With Axial and Peripheral Spondyloarthritis. J Rheumatol. 2021 04; 48(4):513-519. PMID: 33060306.
      Citations:    Fields:    Translation:Humans
    31. Lapane KL, Khan S, Shridharmurthy D, Beccia A, Dub? C, Yi E, Kay J, Liu SH. Primary care physician perspectives on barriers to diagnosing axial Spondyloarthritis: a qualitative study. BMC Fam Pract. 2020 09 29; 21(1):204. PMID: 32993510.
      Citations: 10     Fields:    Translation:Humans
    32. Morrison RA, Jesdale BM, Dub? CE, Nunes AP, Bova CA, Liu SH, Lapane KL. Differences in Staff-Assessed Pain Behaviors among Newly Admitted Nursing Home Residents by Level of Cognitive Impairment. Dement Geriatr Cogn Disord. 2020; 49(3):243-251. PMID: 32610321.
      Citations: 6     Fields:    Translation:Humans
    33. Harkey MS, Lapane KL, Liu SH, Lo GH, McAlindon TE, Driban JB. A Decline in Walking Speed Is Associated With Incident Knee Replacement in Adults With and at Risk for Knee Osteoarthritis. J Rheumatol. 2021 04; 48(4):579-584. PMID: 32541076.
      Citations: 1     Fields:    Translation:Humans
    34. Liu SH, Lapane KL. Scratching the Surface: Itching for Evidence to Reduce Surgical Health Disparities in Total Shoulder Arthroplasty. J Rheumatol. 2020 04; 47(4):490-492. PMID: 32238543.
      Citations: 1     Fields:    Translation:Humans
    35. Masters GA, Li N, Lapane KL, Liu SH, Person SD, Byatt N. Utilization of Health Care Among Perinatal Women in the United States: The Role of Depression. J Womens Health (Larchmt). 2020 07; 29(7):944-951. PMID: 32077784.
      Citations: 3     Fields:    Translation:Humans
    36. Harkey MS, Price LL, Reid KF, Lo GH, Liu SH, Lapane KL, Dantas LO, McAlindon TE, Driban JB. Patient-specific reference values for objective physical function tests: data from the Osteoarthritis Initiative. Clin Rheumatol. 2020 Jun; 39(6):1961-1970. PMID: 32030634.
      Citations:    Fields:    Translation:Humans
    37. Driban JB, Harkey MS, Liu SH, Salzler M, McAlindon TE . Osteoarthritis and Aging: Young Adults with Osteoarthritis. Current Epidemiology Report. 2020; (7):9-15.
    38. Liu SH, Morais SA, Lapane KL, Kay J. Physical activity and attitudes and perceptions towards physical activity in patients with spondyloarthritis: A systematic review. Semin Arthritis Rheum. 2020 04; 50(2):289-302. PMID: 31839210.
      Citations: 3     Fields:    Translation:Humans
    39. Davis JE, Harkey MS, Liu SH, Lapane K, Price LL, Lu B, Lo GH, Eaton CB, Barbe MF, McAlindon TE, Driban JB. Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative. ACR Open Rheumatol. 2019 Aug; 1(6):359-364. PMID: 31777814.
      Citations:    
    40. Liu SH, Hunnicutt JN, Ulbricht CM, Dub? CE, Hume AL, Lapane KL. Adjuvant Use and the Intensification of Pharmacologic Management for Pain in Nursing Home Residents with Cancer: Data from a US National Database. Drugs Aging. 2019 06; 36(6):549-557. PMID: 30924097.
      Citations: 4     Fields:    Translation:Humans
    41. Liu SH, Chrysanthopoulou SA, Chang Q, Hunnicutt JN, Lapane KL. Missing Data in Marginal Structural Models: A Plasmode Simulation Study Comparing Multiple Imputation and Inverse Probability Weighting. Med Care. 2019 03; 57(3):237-243. PMID: 30664611.
      Citations: 1     Fields:    Translation:Humans
    42. Harkey MS, Davis JE, Lu B, Price LL, Eaton CB, Lo GH, Barbe MF, Ward RJ, Zhang M, Liu SH, Lapane KL, MacKay JW, McAlindon TE, Driban JB. Diffuse tibiofemoral cartilage change prior to the development of accelerated knee osteoarthritis: Data from the osteoarthritis initiative. Clin Anat. 2019 Apr; 32(3):369-378. PMID: 30521068.
      Citations: 5     Fields:    Translation:Humans
    43. Hunnicutt JN, Baek J, Alcusky M, Hume AL, Liu SH, Ulbricht CM, Tjia J, Lapane KL. Geographic Variation in the Initiation of Commonly Used Opioids and Dosage Strength in United States Nursing Homes. Med Care. 2018 10; 56(10):847-854. PMID: 30113423.
      Citations: 5     Fields:    Translation:Humans
    44. Hunnicutt JN, Hume AL, Liu SH, Ulbricht CM, Tjia J, Lapane KL. Commonly Initiated Opioids and Risk of Fracture Hospitalizations in United States Nursing Homes. Drugs Aging. 2018 10; 35(10):925-936. PMID: 30187291.
      Citations: 4     Fields:    Translation:Humans
    45. Liu SH, Dub? CE, Eaton CB, Driban JB, McAlindon TE, Lapane KL. Longterm Effectiveness of Intraarticular Injections on Patient-reported Symptoms in Knee Osteoarthritis. J Rheumatol. 2018 08; 45(9):1316-1324. PMID: 29907665.
      Citations: 9     Fields:    Translation:Humans
    46. Davis JE, Liu SH, Lapane K, Harkey MS, Price LL, Lu B, Lo GH, Eaton CB, Barbe MF, McAlindon TE, Driban JB. Adults with incident accelerated knee osteoarthritis are more likely to receive a knee replacement: data from the Osteoarthritis Initiative. Clin Rheumatol. 2018 Apr; 37(4):1115-1118. PMID: 29423719.
      Citations: 9     Fields:    Translation:Humans
    47. Liu SH, Dub? CE, Driban JB, McAlindon TE, Eaton CB, Lapane KL. Patterns of intra-articular injection use after initiation of treatment in patients with knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2017 10; 25(10):1607-1614. PMID: 28627466.
      Citations: 5     Fields:    Translation:Humans
    48. Lapane KL, Liu SH, Dub? CE, Driban JB, McAlindon TE, Eaton CB. Factors Associated with the Use of Hyaluronic Acid and Corticosteroid Injections among Patients with Radiographically Confirmed Knee Osteoarthritis: A Retrospective Data Analysis. Clin Ther. 2017 Feb; 39(2):347-358. PMID: 28139290.
      Citations: 8     Fields:    Translation:Humans
    49. Liu SH, Lapane KL. The Reply. Am J Med. 2016 11; 129(11):e307. PMID: 27770848.
      Citations:    Fields:    
    50. Liu SH, Ulbricht CM, Chrysanthopoulou SA, Lapane KL. Implementation and reporting of causal mediation analysis in 2015: a systematic review in epidemiological studies. BMC Res Notes. 2016 Jul 20; 9:354. PMID: 27439301.
      Citations: 12     Fields:    Translation:Humans
    51. Liu SH, Eaton CB, Driban JB, McAlindon TE, Lapane KL. Comparison of self-report and objective measures of physical activity in US adults with osteoarthritis. Rheumatol Int. 2016 Oct; 36(10):1355-64. PMID: 27435920.
      Citations: 17     Fields:    Translation:Humans
    52. Lapane KL, Liu SH. Commentary: Osteoarthritis and Mortality: Answering Questions or Questioning Answers? Epidemiology. 2016 07; 27(4):477-8. PMID: 26986873.
      Citations: 2     Fields:    Translation:Humans
    53. Liu SH, Driban JB, Eaton CB, McAlindon TE, Harrold LR, Lapane KL. Objectively Measured Physical Activity and Symptoms Change in Knee Osteoarthritis. Am J Med. 2016 05; 129(5):497-505.e1. PMID: 26844633.
      Citations: 16     Fields:    Translation:Humans
    54. Dub? CE, Liu SH, Driban JB, McAlindon TE, Eaton CB, Lapane KL. The relationship between smoking and knee osteoarthritis in the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Mar; 24(3):465-72. PMID: 26432984.
      Citations: 17     Fields:    Translation:Humans
    55. Liu SH, Waring ME, Eaton CB, Lapane KL. Association of Objectively Measured Physical Activity and Metabolic Syndrome Among US Adults With Osteoarthritis. Arthritis Care Res (Hoboken). 2015 Oct; 67(10):1371-8. PMID: 25777463.
      Citations: 19     Fields:    Translation:Humans
    56. Lapane KL, Liu SH, Dub? CE, Yang S, Driban JB, McAlindon TE, Eaton CB. Reply: To PMID 25369996. Arthritis Rheumatol. 2015 May; 67(8):2278-80. PMID: 25891154.
      Citations:    Fields:    Translation:Humans
    57. Lapane KL, Yang S, Driban JB, Liu SH, Dub? CE, McAlindon TE, Eaton CB. Effects of prescription nonsteroidal antiinflammatory drugs on symptoms and disease progression among patients with knee osteoarthritis. Arthritis Rheumatol. 2015 Mar; 67(3):724-32. PMID: 25369996.
      Citations: 30     Fields:    Translation:Humans
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