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    Charles P Emerson Jr. PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentCell and Developmental Biology
    AddressWellstone Program
    55 Lake Avenue North, S5-147
    Worcester MA 01655
    Phone774-455-1571
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentNeurology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

        Bibliographic 
        selected publications
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        1. Zhang Y, King OD, Rahimov F, Jones TI, Ward CW, Kerr JP, Liu N, Emerson CP, Kunkel LM, Partridge TA, Wagner KR. Human skeletal muscle xenograft as a new preclinical model for muscle disorders. Hum Mol Genet. 2014 Jun 15; 23(12):3180-8.
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        2. Pettigrew CA, Asp E, Emerson CP. A new role for Hedgehogs in juxtacrine signaling. Mech Dev. 2014 Feb; 131:137-49.
          View in: PubMed
        3. Himeda CL, Barro MV, Emerson CP. Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer. Dev Biol. 2013 Nov 1; 383(1):7-14.
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        4. Rahimov F, King OD, Leung DG, Bibat GM, Emerson CP, Kunkel LM, Wagner KR. Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16234-9.
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        5. Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30.
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        6. Homma S, Chen JC, Rahimov F, Beermann ML, Hanger K, Bibat GM, Wagner KR, Kunkel LM, Emerson CP, Miller JB. A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function. Eur J Hum Genet. 2012 Apr; 20(4):404-10.
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        7. Stadler G, Chen JC, Wagner K, Robin JD, Shay JW, Emerson CP, Wright WE. Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population. Skelet Muscle. 2011; 1(1):12.
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        8. Rahimov F, King OD, Warsing LC, Powell RE, Emerson CP, Kunkel LM, Wagner KR. Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor. Physiol Genomics. 2011 Apr 27; 43(8):398-407.
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        9. Langsdorf A, Do AT, Kusche-Gullberg M, Emerson CP, Ai X. Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration. Dev Biol. 2007 Nov 15; 311(2):464-77.
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        10. Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development. 2007 Sep; 134(18):3327-38.
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        11. Riobo NA, Lu K, Emerson CP. Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle. 2006 Aug; 5(15):1612-5.
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        12. Riobó NA, Lu K, Ai X, Haines GM, Emerson CP. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4505-10.
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        13. Riobo NA, Haines GM, Emerson CP. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Res. 2006 Jan 15; 66(2):839-45.
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        14. Ai X, Do AT, Kusche-Gullberg M, Lindahl U, Lu K, Emerson CP. Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2. J Biol Chem. 2006 Feb 24; 281(8):4969-76.
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        15. McDermott A, Gustafsson M, Elsam T, Hui CC, Emerson CP, Borycki AG. Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development. 2005 Jan; 132(2):345-57.
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        16. Braquart-Varnier C, Danesin C, Clouscard-Martinato C, Agius E, Escalas N, Benazeraf B, Ai X, Emerson C, Cochard P, Soula C. A subtractive approach to characterize genes with regionalized expression in the gliogenic ventral neuroepithelium: identification of chick sulfatase 1 as a new oligodendrocyte lineage gene. Mol Cell Neurosci. 2004 Apr; 25(4):612-28.
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        17. Wang S, Ai X, Freeman SD, Pownall ME, Lu Q, Kessler DS, Emerson CP. QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):4833-8.
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        18. Miller JB, Emerson CP. Does the road to muscle rejuvenation go through Notch? Sci Aging Knowledge Environ. 2003 Dec 3; 2003(48):pe34.
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        19. Polyák E, Standiford DM, Yakopson V, Emerson CP, Franzini-Armstrong C. Contribution of myosin rod protein to the structural organization of adult and embryonic muscles in Drosophila. J Mol Biol. 2003 Aug 29; 331(5):1077-91.
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        20. Ai X, Do AT, Lozynska O, Kusche-Gullberg M, Lindahl U, Emerson CP. QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling. J Cell Biol. 2003 Jul 21; 162(2):341-51.
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        21. La Rocca SA, Vannucchi S, Pompili M, Pinney DF, Emerson CP, Grossi M, Tatò F. Selective repression of myoD transcription by v-Myc prevents terminal differentiation of quail embryo myoblasts transformed by the MC29 strain of avian myelocytomatosis virus. Oncogene. 2002 Jul 18; 21(31):4838-42.
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        22. Gustafsson MK, Pan H, Pinney DF, Liu Y, Lewandowski A, Epstein DJ, Emerson CP. Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev. 2002 Jan 1; 16(1):114-26.
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        23. Dhoot GK, Gustafsson MK, Ai X, Sun W, Standiford DM, Emerson CP. Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase. Science. 2001 Aug 31; 293(5535):1663-6.
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        24. Standiford DM, Sun WT, Davis MB, Emerson CP. Positive and negative intronic regulatory elements control muscle-specific alternative exon splicing of Drosophila myosin heavy chain transcripts. Genetics. 2001 Jan; 157(1):259-71.
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        25. Borycki AG, Emerson CP. Multiple tissue interactions and signal transduction pathways control somite myogenesis. Curr Top Dev Biol. 2000; 48:165-224.
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        26. Borycki AG, Brunk B, Tajbakhsh S, Buckingham M, Chiang C, Emerson CP. Sonic hedgehog controls epaxial muscle determination through Myf5 activation. Development. 1999 Sep; 126(18):4053-63.
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        27. Bucher EA, Dhoot GK, Emerson MM, Ober M, Emerson CP. Structure and evolution of the alternatively spliced fast troponin T isoform gene. J Biol Chem. 1999 Jun 18; 274(25):17661-70.
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        28. Borycki AG, Li J, Jin F, Emerson CP, Epstein JA. Pax3 functions in cell survival and in pax7 regulation. Development. 1999 Apr; 126(8):1665-74.
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        29. Davis MB, Dietz J, Standiford DM, Emerson CP. Transposable element insertions respecify alternative exon splicing in three Drosophila myosin heavy chain mutants. Genetics. 1998 Nov; 150(3):1105-14.
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        30. Borycki AG, Mendham L, Emerson CP. Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development. 1998 Feb; 125(4):777-90.
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        31. Standiford DM, Davis MB, Sun W, Emerson CP. Splice-junction elements and intronic sequences regulate alternative splicing of the Drosophila myosin heavy chain gene transcript. Genetics. 1997 Oct; 147(2):725-41.
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        32. Borycki AG, Emerson CP. Muscle determination: another key player in myogenesis? Curr Biol. 1997 Oct 1; 7(10):R620-3.
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        33. Borycki AG, Strunk KE, Savary R, Emerson CP. Distinct signal/response mechanisms regulate pax1 and QmyoD activation in sclerotomal and myotomal lineages of quail somites. Dev Biol. 1997 May 15; 185(2):185-200.
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        34. Standiford DM, Davis MB, Miedema K, Franzini-Armstrong C, Emerson CP. Myosin rod protein: a novel thick filament component of Drosophila muscle. J Mol Biol. 1997 Jan 10; 265(1):40-55.
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        35. Pownall ME, Strunk KE, Emerson CP. Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos. Development. 1996 May; 122(5):1475-88.
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        36. Pinney DF, de la Brousse FC, Faerman A, Shani M, Maruyama K, Emerson CP. Quail myoD is regulated by a complex array of cis-acting control sequences. Dev Biol. 1995 Jul; 170(1):21-38.
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        37. Goldhamer DJ, Brunk BP, Faerman A, King A, Shani M, Emerson CP. Embryonic activation of the myoD gene is regulated by a highly conserved distal control element. Development. 1995 Mar; 121(3):637-49.
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        38. Emerson CP. Embryonic signals for skeletal myogenesis: arriving at the beginning. Curr Opin Cell Biol. 1993 Dec; 5(6):1057-64.
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        39. Litvin J, Montgomery MO, Goldhamer DJ, Emerson CP, Bader DM. Identification of DNA-binding protein(s) in the developing heart. Dev Biol. 1993 Apr; 156(2):409-17.
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        40. Pownall ME, Emerson CP. Sequential activation of three myogenic regulatory genes during somite morphogenesis in quail embryos. Dev Biol. 1992 May; 151(1):67-79.
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        41. Goldhamer DJ, Faerman A, Shani M, Emerson CP. Regulatory elements that control the lineage-specific expression of myoD. Science. 1992 Apr 24; 256(5056):538-42.
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        42. Shani M, Faerman A, Emerson CP, Pearson-White S, Dekel I, Magal Y. The consequences of a constitutive expression of MyoD1 in ES cells and mouse embryos. Symp Soc Exp Biol. 1992; 46:19-36.
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        43. Hastings GA, Emerson CP. Myosin functional domains encoded by alternative exons are expressed in specific thoracic muscles of Drosophila. J Cell Biol. 1991 Jul; 114(2):263-76.
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        44. de la Brousse FC, Emerson CP. Localized expression of a myogenic regulatory gene, qmf1, in the somite dermatome of avian embryos. Genes Dev. 1990 Apr; 4(4):567-81.
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        45. Pinney DF, Emerson CP. 10T1/2 cells: an in vitro model for molecular genetic analysis of mesodermal determination and differentiation. Environ Health Perspect. 1989 Mar; 80:221-7.
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        46. Pearson-White SH, Emerson CP. A novel hybrid alpha-tropomyosin in fibroblasts is produced by alternative splicing of transcripts from the skeletal muscle alpha-tropomyosin gene. J Biol Chem. 1987 Nov 25; 262(33):15998-6010.
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        47. Bowman LH, Emerson CP. Formation and stability of cytoplasmic mRNAs during myoblast differentiation: pulse-chase and density labeling analyses. Dev Biol. 1980 Nov; 80(1):146-66.
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        48. Devlin RB, Emerson CP. Coordinate accumulation of contractile protein mRNAs during myoblast differentiation. Dev Biol. 1979 Mar; 69(1):202-16.
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        49. Emerson CP, Beckner SK. Activation of myosin synthesis in fusing and mononucleated myoblasts. J Mol Biol. 1975 Apr 25; 93(4):431-47.
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        50. Emerson CP, Humphreys T. Regulation of DNA-like RNA and the apparent activation of ribosomal RNA synthesis in sea urchin embryos: quantitative measurements of newly synthesized RNA. Dev Biol. 1970 Sep; 23(1):86-112.
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