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    Oliver Davis King PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentCell and Developmental Biology
    AddressWellstone Program
    55 Lake Avenue North, S5-141
    Worcester MA 01655
    Phone774-455-1572
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentNeurology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBioinformatics and Computational Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

        Overview 
        Narrative

        Wellstone Program / Cell and Developmental Biology

        Academic Background

        2013-present: Assistant Professor, Cell and Developmental Biology, UMMS
        2007-2013: Scientist, Boston Biomedical Research Institute
        2004-2007: Postdoctoral Associate, Whitehead Institute
        2001-2004: Postdoctoral Fellow, Harvard Medical School
        2001: PhD in Mathematics, University of California, Berkeley
        1999: MS in Computer Science, University of California, Berkeley
        1992: BA in Mathematics, University of Hawaii, Manoa



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Zhang Y, King OD, Rahimov F, Jones TI, Ward CW, Kerr JP, Liu N, Emerson CP, Kunkel LM, Partridge TA, Wagner KR. Human skeletal muscle xenograft as a new preclinical model for muscle disorders. Hum Mol Genet. 2014 Feb 7.
          View in: PubMed
        2. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469.
          View in: PubMed
        3. Jackson WS, Borkowski AW, Watson NE, King OD, Faas H, Jasanoff A, Lindquist S. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases. Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36):14759-64.
          View in: PubMed
        4. Stadler G, King OD, Robin JD, Shay JW, Wright WE. Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story?. Rare Diseases. 2013; 1:e26142.
        5. Chesi A, Staahl BT, Jovicic A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci. 2013 May 26; 16(7):851-5.
          View in: PubMed
        6. Stadler G, Rahimov F, King OD, Chen JC, Robin JD, Wagner KR, Shay JW, Emerson CP, Wright WE. Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nat Struct Mol Biol. 2013 Jun; 20(6):671-8.
          View in: PubMed
        7. Li YR, King OD, Shorter J, Gitler AD. Stress granules as crucibles of ALS pathogenesis. J Cell Biol. 2013 Apr 29; 201(3):361-72.
          View in: PubMed
        8. Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature. 2013 Mar 28; 495(7442):467-73.
          View in: PubMed
        9. Rahimov F, King OD, Leung DG, Bibat GM, Emerson CP, Kunkel LM, Wagner KR. Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16234-9.
          View in: PubMed
        10. Gallardo CM, Gunapala KM, King OD, Steele AD. Daily Scheduled High Fat Meals Moderately Entrain Behavioral Anticipatory Activity, Body Temperature, and Hypothalamic c-Fos Activation. PLoS One. 2012; 7(7):e41161.
          View in: PubMed
        11. Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30.
          View in: PubMed
        12. McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S. Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. ACS Chem Biol. 2012 Sep 21; 7(9):1520-8.
          View in: PubMed
        13. Luby MD, Hsu CT, Shuster SA, Gallardo CM, Mistlberger RE, King OD, Steele AD. Food Anticipatory Activity Behavior of Mice across a Wide Range of Circadian and Non-Circadian Intervals. PLoS One. 2012; 7(5):e37992.
          View in: PubMed
        14. Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Mol Genet. 2012 Jul 1; 21(13):2899-911.
          View in: PubMed
        15. King OD, Gitler AD, Shorter J. The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Res. 2012 Jun 26; 1462:61-80.
          View in: PubMed
        16. Zarringhalam K, Ka M, Kook YH, Terranova JI, Suh Y, King OD, Um M. An open system for automatic home-cage behavioral analysis and its application to male and female mouse models of Huntington's disease. Behav Brain Res. 2012 Apr 1; 229(1):216-25.
          View in: PubMed
        17. Matsumiya LC, Sorge RE, Sotocinal SG, Tabaka JM, Wieskopf JS, Zaloum A, King OD, Mogil JS. Using the mouse grimace scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J Am Assoc Lab Anim Sci. 2012; 51(1):42-9.
          View in: PubMed
        18. Couthouis J, Hart MP, Shorter J, Dejesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD. Feature Article: From the Cover: A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):20881-90.
          View in: PubMed
        19. Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, Mapplebeck JC, Wei P, Zhan S, Zhang S, McDougall JJ, King OD, Mogil JS. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain. 2011; 7:55.
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        20. Halfmann R, Alberti S, Krishnan R, Lyle N, O'Donnell CW, King OD, Berger B, Pappu RV, Lindquist S. Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell. 2011 Jul 8; 43(1):72-84.
          View in: PubMed
        21. Rahimov F, King OD, Warsing LC, Powell RE, Emerson CP, Kunkel LM, Wagner KR. Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor. Physiol Genomics. 2011 Apr 27; 43(8):398-407.
          View in: PubMed
        22. Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb; 8(2):159-64.
          View in: PubMed
        23. Cushman M, Johnson BS, King OD, Gitler AD, Shorter J. Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci. 2010 Apr 15; 123(Pt 8):1191-201.
          View in: PubMed
        24. Jackson WS, Borkowski AW, Faas H, Steele AD, King OD, Watson N, Jasanoff A, Lindquist S. Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice. Neuron. 2009 Aug 27; 63(4):438-50.
          View in: PubMed
        25. Alberti S, Halfmann R, King O, Kapila A, Lindquist S. A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell. 2009 Apr 3; 137(1):146-58.
          View in: PubMed
        26. Yeger-Lotem E, Riva L, Su LJ, Gitler AD, Cashikar AG, King OD, Auluck PK, Geddie ML, Valastyan JS, Karger DR, Lindquist S, Fraenkel E. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet. 2009 Mar; 41(3):316-23.
          View in: PubMed
        27. Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A. 2008 Sep 9; 105(36):13626-31.
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        28. Tian W, Zhang LV, Tasan M, Gibbons FD, King OD, Park J, Wunderlich Z, Cherry JM, Roth FP. Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol. 2008; 9 Suppl 1:S7.
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        29. Steele AD, King OD, Jackson WS, Hetz CA, Borkowski AW, Thielen P, Wollmann R, Lindquist S. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci. 2007 Nov 21; 27(47):13022-7.
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        30. King OD, Masel J. The evolution of bet-hedging adaptations to rare scenarios. Theor Popul Biol. 2007 Dec; 72(4):560-75.
          View in: PubMed
        31. Steele AD, Jackson WS, King OD, Lindquist S. The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A. 2007 Feb 6; 104(6):1983-8.
          View in: PubMed
        32. King OD, Gaborit P. Binary templates for comma-free DNA codes. Discrete Appl Math (Computational Molecular Biology Series, Issue V). 2007; 155(6-7):831-839.
        33. Masel J, King OD, Maughan H. The loss of adaptive plasticity during long periods of environmental stasis. Am Nat. 2007 Jan; 169(1):38-46.
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        34. Zhang LV, King OD, Wong SL, Goldberg DS, Tong AH, Lesage G, Andrews B, Bussey H, Boone C, Roth FP. Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol. 2005; 4(2):6.
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        35. Gaborit P, King OD. Linear constructions for DNA codes. Theor Comput Sci. 2005; 334:99-113.
        36. King OD. Comment on "Subgraphs in random networks". Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Nov; 70(5 Pt 2):058101; author reply 058102.
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        37. Wong SL, Zhang LV, Tong AH, Li Z, Goldberg DS, King OD, Lesage G, Vidal M, Andrews B, Bussey H, Boone C, Roth FP. Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A. 2004 Nov 2; 101(44):15682-7.
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        38. Asthana S, King OD, Gibbons FD, Roth FP. Predicting protein complex membership using probabilistic network reliability. Genome Res. 2004 Jun; 14(6):1170-5.
          View in: PubMed
        39. Zhang LV, Wong SL, King OD, Roth FP. Predicting co-complexed protein pairs using genomic and proteomic data integration. BMC Bioinformatics. 2004 Apr 16; 5:38.
          View in: PubMed
        40. Elias JE, Gibbons FD, King OD, Roth FP, Gygi SP. Intensity-based protein identification by machine learning from a library of tandem mass spectra. Nat Biotechnol. 2004 Feb; 22(2):214-9.
          View in: PubMed
        41. Berriz GF, King OD, Bryant B, Sander C, Roth FP. Characterizing gene sets with FuncAssociate. Bioinformatics. 2003 Dec 12; 19(18):2502-4.
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        42. King OD, Roth FP. A non-parametric model for transcription factor binding sites. Nucleic Acids Res. 2003 Oct 1; 31(19):e116.
          View in: PubMed
        43. King OD, Foulger RE, Dwight SS, White JV, Roth FP. Predicting gene function from patterns of annotation. Genome Res. 2003 May; 13(5):896-904.
          View in: PubMed
        44. Berriz GF, White JV, King OD, Roth FP. GoFish finds genes with combinations of Gene Ontology attributes. Bioinformatics. 2003 Apr 12; 19(6):788-9.
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        45. King OD, Lee JC, Dudley AM, Janse DM, Church GM, Roth FP. Predicting phenotype from patterns of annotation. Bioinformatics. 2003; 19 Suppl 1:i183-9.
          View in: PubMed
        46. King OD. A mass formula for unimodular lattices with no roots. Math Comput. 2003; 72(242):839-863.
        47. King OD. Bounds for DNA codes with constant GC-content. Electron J Comb. 2003; 10(1):#33.
        48. King OD. The mass of extremal doubly-even self-dual codes of length 40. IEEE Trans Inform Theory. 2001; 47(6):2558-2560.
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