Amyotrophic Lateral Sclerosis

"Amyotrophic Lateral Sclerosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

Descriptor ID	D000690
MeSH Number(s)	C10.228.854.139 C10.574.562.250 C10.574.950.050 C10.668.467.250 C18.452.845.800.050
Concept/Terms	Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Sclerosis, Amyotrophic Lateral Charcot Disease Motor Neuron Disease, Amyotrophic Lateral Sclerosis Lou Gehrig Disease Lou Gehrig's Disease Lou-Gehrigs Disease Disease, Lou-Gehrigs ALS (Amyotrophic Lateral Sclerosis) Gehrig's Disease Gehrig Disease Gehrigs Disease Amyotrophic Lateral Sclerosis, Guam Form Amyotrophic Lateral Sclerosis, Guam Form Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam Guam Form of Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 Guam Disease Disease, Guam Amyotrophic Lateral Sclerosis With Dementia Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis

Below are MeSH descriptors whose meaning is more general than "Amyotrophic Lateral Sclerosis".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Spinal Cord Diseases [C10.228.854]
Amyotrophic Lateral Sclerosis [C10.228.854.139]
Neurodegenerative Diseases [C10.574]
Motor Neuron Disease [C10.574.562]
Amyotrophic Lateral Sclerosis [C10.574.562.250]
TDP-43 Proteinopathies [C10.574.950]
Amyotrophic Lateral Sclerosis [C10.574.950.050]
Neuromuscular Diseases [C10.668]
Motor Neuron Disease [C10.668.467]
Amyotrophic Lateral Sclerosis [C10.668.467.250]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
Proteostasis Deficiencies [C18.452.845]
TDP-43 Proteinopathies [C18.452.845.800]
Amyotrophic Lateral Sclerosis [C18.452.845.800.050]

Below are MeSH descriptors whose meaning is more specific than "Amyotrophic Lateral Sclerosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyotrophic Lateral Sclerosis" by people in this website by year, and whether "Amyotrophic Lateral Sclerosis" was a major or minor topic of these publications.

Bar chart showing 322 publications over 30 distinct years, with a maximum of 23 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	1	1	2
1998	1	0	1
1999	1	0	1
2000	2	0	2
2001	1	0	1
2002	2	1	3
2003	8	1	9
2004	4	0	4
2005	11	0	11
2006	7	1	8
2007	6	0	6
2008	12	2	14
2009	12	0	12
2010	13	0	13
2011	7	1	8
2012	10	1	11
2013	17	1	18
2014	12	3	15
2015	12	2	14
2016	21	1	22
2017	22	1	23
2018	20	0	20
2019	14	1	15
2020	10	2	12
2021	16	2	18
2022	17	0	17
2023	16	0	16
2024	14	1	15
2025	9	1	10

Below are the most recent publications written about "Amyotrophic Lateral Sclerosis" by people in Profiles.

Iacoangeli A, Dilliott AA, Al Khleifat A, Andersen PM, Basak NA, Cooper-Knock J, Corcia P, Couratier P, deCarvalho M, Drory VE, Glass JD, Gotkine M, Lerner YM, Hardiman O, Landers JE, McLaughlin RL, Pardina JSM, Morrison K, Pinto S, Povedano M, Shaw CE, Shaw PJ, Silani V, Ticozzi N, van Damme P, van den Berg LH, Vourc'h P, Weber M, Veldink JH, Dobson R, Rouleau GA, Al-Chalabi A, Farhan SMK. Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications. J Neurol Neurosurg Psychiatry. 2025 Sep 12; 96(10):928-936.

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Masegosa VM, Fritz E, Corvalan D, Rojas F, Garc?s P, Navarro X, Bloms-Funke P, van Zundert B, Herrando-Grabulosa M. Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media. ACS Chem Neurosci. 2025 Aug 06; 16(15):2887-2900.

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Shneider NA, Harms MB, Korobeynikov VA, Rifai OM, Hoover BN, Harrington EA, Aziz-Zaman S, Singleton J, Jamil A, Madan VR, Lee I, Andrews JA, Smiley RM, Alam MM, Black LE, Shin M, Watts JK, Walk D, Newman D, Pascuzzi RM, Weber M, Neuwirth C, Da Cruz S, Soriano A, Lane R, Henry S, Mathews J, Jafar-Nejad P, Norris D, Rigo F, Brown RH, Miller S, Crean R, Bennett CF. Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series. Lancet. 2025 Jun 07; 405(10494):2075-2086.

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Weiss A, Gilbert JW, Rivera Flores IV, Belgrad J, Ferguson C, Dogan EO, Wightman N, Mocarski K, Echeverria D, Harkins AL, Summers A, Bramato B, McHugh N, Furgal R, Yamada N, Cooper D, Monopoli K, Godinho BMDC, Hassler MR, Yamada K, Greer P, Henninger N, Brown RH, Khvorova A. RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. Mol Ther. 2025 Aug 06; 33(8):3917-3938.

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Fyrberg E, Learnard H, Lee S, Jun YW, Gao FB. New Mouse Lines That Drive Tetracycline-Controlled Gene Expression in a Small Subset of Spinal Cord Dorsal Horn Neurons. eNeuro. 2025 Apr; 12(4).

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Kwon S, Kim B, Han KD, Jung W, Cho EB, Shin DW, Min JH. Increased risk of ischemic stroke in amyotrophic lateral sclerosis: a nationwide cohort study in South Korea. Neurol Sci. 2025 Jun; 46(6):2687-2695.

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Andrews J, Paganoni S, Macklin EA, Chibnik LB, Quintana M, Saville BR, Detry MA, Vestrucci M, Marion J, McGlothlin A, Young E, Chase M, Pothier L, Harkey B, Yu H, Sherman A, Shefner J, Hall M, Kittle G, Connolly MR, Berry JD, D'Agostino D, Tustison E, Giacomelli E, Scirocco E, Alameda G, Locatelli E, Ho D, Quick A, Heitzman D, Ajroud-Driss S, Appel SH, Shroff S, Katz J, Felice K, Maragakis NJ, Simmons Z, Goutman SA, Olney N, Miller T, Fernandes JA, Ilieva H, Jawdat O, Weiss MD, Foster L, Vu T, Ladha S, Owegi MA, Newman DS, Arcila-Londono X, Jackson CE, Swenson A, Heiman-Patterson T, Caress J, Fee D, Peltier A, Lewis R, Rosenfeld J, Walk D, Johnson K, Elliott M, Kasarskis EJ, Rutkove S, McIlduff CE, Bedlack R, Elman L, Goyal NA, Rezania K, Twydell P, Benatar M, Glass J, Cohen JA, Jones V, Zilliox L, Wymer JP, Beydoun SR, Shah J, Pattee GL, Martinez-Thompson J, Nayar S, Granit V, Donohue M, Grossman K, Campbell DJ, Qureshi IA, Cudkowicz ME, Babu S. Verdiperstat in Amyotrophic Lateral Sclerosis: Results From the Randomized HEALEY ALS Platform Trial. JAMA Neurol. 2025 Apr; 82(4):333-343.

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Paganoni S, Fournier CN, Macklin EA, Chibnik LB, Quintana M, Saville BR, Detry MA, Vestrucci M, Marion J, McGlothlin A, Ajroud-Driss S, Chase M, Pothier L, Harkey BA, Yu H, Sherman AV, Shefner JM, Hall M, Kittle G, Berry JD, Babu S, Andrews J, Dagostino D, Tustison E, Giacomelli E, Scirocco E, Alameda G, Locatelli E, Ho D, Quick A, Katz J, Heitzman D, Appel SH, Shroff S, Felice K, Maragakis NJ, Simmons Z, Miller TM, Olney N, Weiss MD, Goutman SA, Fernandes JA, Jawdat O, Owegi MA, Foster LA, Vu T, Ilieva H, Newman DS, Arcila-Londono X, Jackson CE, Ladha S, Heiman-Patterson T, Caress JB, Swenson A, Peltier A, Lewis R, Fee D, Elliott M, Bedlack R, Kasarskis EJ, Elman L, Rosenfeld J, Walk D, McIlduff C, Twydell P, Young E, Johnson K, Rezania K, Goyal NA, Cohen JA, Benatar M, Jones V, Glass J, Shah J, Beydoun SR, Wymer JP, Zilliox L, Nayar S, Pattee GL, Martinez-Thompson J, Harvey B, Patel S, Mahoney P, Duda PW, Cudkowicz ME. Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. JAMA Netw Open. 2025 02 03; 8(2):e2459058.

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Dogan EO, Simonini SR, Bouley J, Weiss A, Brown RH, Henninger N. Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis. Ann Neurol. 2025 May; 97(5):963-975.

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van Zundert B, Montecino M. Epigenetics in Neurodegenerative Diseases. Subcell Biochem. 2025; 108:73-109.

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