Below are the most recent publications written about "Amyotrophic Lateral Sclerosis" by people in Profiles.
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James RE, Bekier M, Lee PJ, Schroeder FA, Evans LT, Wagner FF, Hickman D, Richardson T, Hatzipetros T, Vieira F, Callizot N, Modi S, Hooker JM, Kranz JE, Brown RH, Barmada SJ, Gilbert TM. A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia. Brain. 2026 May 05; 149(5):1586-1603.
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Neumann M, Kothare H, Bartlett M, Roesler O, Suendermann-Oeft C, Hosamath A, Arbatti L, Pautler D, Suendermann-Oeft D, Cadavid D, Scannevin RH, Hoffmann I, Tarachandani A, Haley T, Raines S, Damme PV, Tienari P, Solje E, Jokela M, Genge A, O'Connell C, Eijk RPAV, Berg LHVD, Ramanarayanan V. Speech-based digital endpoints track ALS progression and align with standard clinical outcomes: evidence from the VRG50635 trial. Sci Rep. 2026 Apr 14; 16(1).
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Hop PJ, Kooyman M, Kenna BJ, Zwamborn RAJ, van Eijk KR, Wang Y, van Dijk CH, Bekema E, van Rheenen W, Beele P, van Vugt JJFA, Khleifat AA, Iacoangeli A, Cooper-Knock J, Smith BN, Topp S, van der Kooi AJ, Fominykh V, Drory V, Lerner Y, Shovman Y, Rowe DB, Williams KL, McLaughlin RL, Hurt J, Huang Y, Chen CY, Tsai E, Runz H, Aronica E, Groen EJN, van Es MA, Pasterkamp RJ, Farhan SMK, Garton FC, McRae AF, McCombe PA, Henderson RD, Fan D, ?lachtov? L, H?yer H, Nishimura AL, Cauchi RJ, Brylev L, Rogelj B, Koritnik B, Zidar J, Salas T, Mora Pardina JS, Gotkine M, Povedano M, Corcia P, Vourc'h P, Couratier P, Weber M, Kiernan MC, Pamphlett R, Blair IP, de Carvalho M, Basak NA, Ingre C, Andersen PM, Zinman L, Rogaeva E, MacKenzie IR, Dupre N, Rouleau GA, Traynor BJ, Ticozzi N, Chi? A, Silani V, Hardiman O, Phatnani H, Harms MB, Dalgard CL, Glass JD, Landers JE, Van Damme P, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi A, van den Berg LH, Kenna KP, Veldink JH. Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis. Nat Genet. 2026 Apr; 58(4):717-725.
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Gontier G, Kim G, Wang C, Zhu K, Gau R, Zhang N, Naphade S, Stewart A, Schmidt MJ, Galemmo R, Shook B, Tarachandani A, Choi I, Raines S, Scannevin RH, Grievink HW, Smits LMG, Kremer PHC, Cadavid D. Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB): A Translational Pharmacodynamic Biomarker for PIKfyve Inhibition With VRG50635. Clin Transl Sci. 2026 Feb; 19(2):e70489.
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Jun YW, Lee S, Almeida S, Freude KK, Ichida JK, Gao FB. The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD. Nat Commun. 2025 Dec 20; 17(1):1007.
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Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT, Desai RR, Keuss MJ, Barattucci S, Zanovello M, Mehta PR, DeKeyser JM, Limone F, Lee J, Brown AL, Leyton-Jaimes MF, Nash LA, Juan IGS, Aronica E, Wainger BJ, Shah M, Goswami A, Shneider NA, Dickson DW, Burrone J, Zhang C, Wichterle H, Petrucelli L, Watts JK, George AL, Fratta P, Eggan K, Kiskinis E. TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD. Nat Neurosci. 2025 Dec; 28(12):2476-2492.
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Iacoangeli A, Dilliott AA, Al Khleifat A, Andersen PM, Basak NA, Cooper-Knock J, Corcia P, Couratier P, deCarvalho M, Drory VE, Glass JD, Gotkine M, Lerner YM, Hardiman O, Landers JE, McLaughlin RL, Pardina JSM, Morrison K, Pinto S, Povedano M, Shaw CE, Shaw PJ, Silani V, Ticozzi N, van Damme P, van den Berg LH, Vourc'h P, Weber M, Veldink JH, Dobson R, Rouleau GA, Al-Chalabi A, Farhan SMK. Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications. J Neurol Neurosurg Psychiatry. 2025 Sep 12; 96(10):928-936.
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Dulski J, Boddapati AK, Risi B, Iruzubieta P, Orlacchio A, Fern?ndez-Torr?n R, Castillo-Trivi?o T, L?pez de Munain A, Vucic S, Padovani A, Kaat LD, Barakat TS, Petrucelli L, Prudencio M, Landers JE, Weishaupt JH, Prokop A, Filosto M, Wszolek ZK, Pant DC. Targeted plasma proteomics uncover proteins associated with KIF5A-linked SPG10 and ALS spectrum disorders. HGG Adv. 2026 Jan 15; 7(1):100498.
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Masegosa VM, Fritz E, Corvalan D, Rojas F, Garc?s P, Navarro X, Bloms-Funke P, van Zundert B, Herrando-Grabulosa M. Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media. ACS Chem Neurosci. 2025 Aug 06; 16(15):2887-2900.
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Shneider NA, Harms MB, Korobeynikov VA, Rifai OM, Hoover BN, Harrington EA, Aziz-Zaman S, Singleton J, Jamil A, Madan VR, Lee I, Andrews JA, Smiley RM, Alam MM, Black LE, Shin M, Watts JK, Walk D, Newman D, Pascuzzi RM, Weber M, Neuwirth C, Da Cruz S, Soriano A, Lane R, Henry S, Mathews J, Jafar-Nejad P, Norris D, Rigo F, Brown RH, Miller S, Crean R, Bennett CF. Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series. Lancet. 2025 Jun 07; 405(10494):2075-2086.