Michael A King PhD
|Institution||University of Massachusetts Medical School|
|Address||University of Massachusetts Medical School|
55 Lake Avenue North
Worcester MA 01655
|Institution||UMMS - School of Medicine|
|Institution||UMMS - Graduate School of Biomedical Sciences|
|Department||Biochemistry and Molecular Pharmacology|
University of Rochester, PhD, 1978
University of Alabama Birmingham, Post-Doc
Correction for causes of image degradation in nuclear medicine such as attenuation, distance-dependent spatial-resolution, and scatter.
Tomographic image reconstruction for SPECT and PET.
Assessment of image quality by task performance studies using human and numerical observers.
Quantitation of activity and assessement of function.
Image segmentation and computer vision applications in nuclear medicine.
Above figure illustrates the degradation of a SPECT transverse slice through the chest by photon attenuation, the acquisition of scattered photons, and the finite imaging system spatial resolution.
At left side is the true source distribution in this simulated image. Note the shape edges and uniform intensity through the soft tissues, lungs, liver, and heart.
Reconstruction of simulated projections from this distribution look exactly like the source distribution in the absence of attenuation, scatter, and system spatial resolution illustrating the success of reconstruction methods with ideal data.
At the left is the slice reconstructed from data which has included the impact of attenuation, scatter, and system spatial resolution. Note the variation in intensity in regions of uniform source distribution, and distortation in shape.
Bringing compensation strategies for such degradations into the clinical use is the MAJOR GOAL of our research efforts.
To learn more about SPECT compensation strategies for these degradations you can read a PDF file with our review chapter on this topic.
Attenuation, Scatter, and Spatial Resolution Compensation in SPECT, to appear in forth coming book EMISSION TOMOGRAPHY: The Fundamentals of PET and SPECT, M. N. Wernick and J. N. Aarsvold, eds., Academic Press.
Nuclear Medicine Instrumentation I : A 4 credit hour course covering radiological physics and instrumentation for Nuclear Medicine Technologists.
Nuclear Medicine Instrumentation II : A 4 credit hour course covering planar and tomographic nuclear medicine imaging, and computer applications.
Physics of Radiology for Residents
List of Graduate Students and Post-Doctoral Fellows
Honors and Awards
Current Grant Support
1. NIH, No R01-HL122484, Probing Dose Limits in Cardiac SPECT with Reconstruction and Personalized Imaging. M. N. Wernick of IIT contact PI, M. A. King UMass MPI, 5/1/2014-4/30/2019.
2. NIH, No R01-EB022092, Combined Multi-Pinhole and Fan-Beam Brain SPECT. M. A. King, PI, 5/18/2016-2/29/2020.
3. NIH, No R01-EB020658, Towards in vivo imaging with bench-top x-ray fluorescence computed tomography. S. H. Cho PI, A. Karellas UMass Sub PI, 4/01/2016–1/31/2020, Role: M. A. King, Co-investigator
4. NIH, No. R01 EB022521, AdaptiSPECT-C: A Next-Generation, Adaptive Brain-Imaging SPECT System for Drug Discovery and Clinical Imaging, M. A. King, contact PI, L. Furenlid, MPI, G. Zubal, MPI, 9/1/2016-8/30/2021.
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