Gene Knock-In Techniques

"Gene Knock-In Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques used to add in exogenous gene sequence such as mutated genes; REPORTER GENES, to study mechanisms of gene expression; or regulatory control sequences, to study effects of temporal changes to GENE EXPRESSION.

Descriptor ID	D055879
MeSH Number(s)	E05.393.335.249
Concept/Terms	Gene Knock-In Techniques Gene Knock-In Techniques Gene Knock-In Technique Knock-In Technique, Gene Knock-In Techniques, Gene Technique, Gene Knock-In Techniques, Gene Knock-In Gene Knock-In Gene Knock-Ins Knock-In, Gene Knock-Ins, Gene Gene Knock In Gene Knock Ins In, Gene Knock Ins, Gene Knock Knock In, Gene Knock Ins, Gene Gene Knock In Techniques

Below are MeSH descriptors whose meaning is more general than "Gene Knock-In Techniques".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]
Gene Knock-In Techniques [E05.393.335.249]

Below are MeSH descriptors whose meaning is related to "Gene Knock-In Techniques".

Below are MeSH descriptors whose meaning is more specific than "Gene Knock-In Techniques".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Knock-In Techniques" by people in this website by year, and whether "Gene Knock-In Techniques" was a major or minor topic of these publications.

Bar chart showing 36 publications over 14 distinct years, with a maximum of 7 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	2	3	5
2010	0	1	1
2011	0	2	2
2012	0	1	1
2013	0	3	3
2014	0	4	4
2015	0	4	4
2016	0	1	1
2017	0	1	1
2018	0	1	1
2019	2	5	7
2022	0	1	1
2025	1	2	3
2026	2	0	2

Below are the most recent publications written about "Gene Knock-In Techniques" by people in Profiles.

Papadopoulou AS, Alterman J, Landles C, Smith EJ, Conroy F, Phillips J, Canibano-Pico M, Nita IM, Osborne GF, Iqbal A, Aldous SG, Bondulich MK, Gomez-Paredes C, Sathasivam K, O'Reilly D, Echeverria D, Bobkov K, Greene JR, Aronin N, Khvorova A, Bates GP. Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model. Sci Transl Med. 2026 Mar 18; 18(841):eadw2495.

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Castelli JMP, Poljakov K, Jwa Y, Cunningham R, Cassidy ME, Gray MD, Sanchez Gaytan JN, Enstrom MR, Gastelum G, Wang Z, Linton JD, Rongvaux A, Taylor JJ, Adair JE. In vivo production of an anti-HIV antibody in mice by non-viral gene knockin in primate hematopoietic stem and progenitor cells. Mol Ther. 2026 May 06; 34(5):2754-2769.

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Mathews EW, Coffey SR, G?rtner A, Belgrad J, Bragg RM, O'Reilly D, Cantle JP, McHugh C, Summers A, Fentz J, Schwagarus T, Cornelius A, Lingos I, Burch Z, Kovalenko M, Andrew MA, Bennett CF, Kordasiewicz HB, Marchionini DM, Wilkinson H, Vogt TF, Beuzer P, Pinto RM, Khvorova A, Howland D, Wheeler VC, Carroll JB. Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding. Nat Commun. 2025 Nov 14; 16(1):10009.

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Feng HZ, Strauss KA, Jin JP. Potential cytotoxicity of truncated slow skeletal muscle troponin T (ssTnT) in a loss of function TNNT1 myopathy mouse model. FEBS J. 2025 Oct; 292(20):5525-5539.

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Oikemus S, Hu K, Shin M, Idrizi F, Goodman-Khan A, Kolb A, Ghanta KS, Lee J, Wagh A, Wolfe SA, Zhu LJ, Watts JK, Lawson ND. Identifying optimal conditions for precise knock-in of exogenous DNA into the zebrafish genome. Development. 2025 Jun 15; 152(12).

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Skovs? S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-M?neur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nat Commun. 2022 02 08; 13(1):735.

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Buchwald JE, Martins PN. Designer organs: The future of personalized transplantation. Artif Organs. 2022 Feb; 46(2):180-190.

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Wang Q, Hern?ndez-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution. Nat Commun. 2021 05 26; 12(1):3175.

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McAdam RL, Morton A, Gordon SL, Alterman JF, Khvorova A, Cousin MA, Smillie KJ. Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington's disease. Neurobiol Dis. 2020 02; 134:104637.

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Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-?B Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312.

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