Gene Targeting

"Gene Targeting" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.

Descriptor ID	D018390
MeSH Number(s)	E05.393.335
Concept/Terms	Gene Targeting Gene Targeting Gene Targetings Targeting, Gene Targetings, Gene

Below are MeSH descriptors whose meaning is more general than "Gene Targeting".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]

Below are MeSH descriptors whose meaning is more specific than "Gene Targeting".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Targeting" by people in this website by year, and whether "Gene Targeting" was a major or minor topic of these publications.

Bar chart showing 65 publications over 24 distinct years, with a maximum of 9 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1997	0	1	1
1998	1	1	2
1999	0	1	1
2000	0	1	1
2001	1	2	3
2002	0	1	1
2003	2	3	5
2004	3	3	6
2005	1	2	3
2006	3	6	9
2007	1	1	2
2008	1	2	3
2009	1	1	2
2011	0	3	3
2012	3	1	4
2013	1	2	3
2014	1	1	2
2015	3	2	5
2016	1	1	2
2018	1	0	1
2019	1	1	2
2020	1	1	2
2021	0	1	1

Below are the most recent publications written about "Gene Targeting" by people in Profiles.

Dasgupta I, Flotte TR, Keeler AM. CRISPR/Cas-Dependent and Nuclease-Free In Vivo Therapeutic Gene Editing. Hum Gene Ther. 2021 03; 32(5-6):275-293.

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Hosur V, Low BE, Li D, Stafford GA, Kohar V, Shultz LD, Wiles MV. Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation. Genome Biol. 2020 07 09; 21(1):168.

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Zeng J, Wu Y, Ren C, Bonanno J, Shen AH, Shea D, Gehrke JM, Clement K, Luk K, Yao Q, Kim R, Wolfe SA, Manis JP, Pinello L, Joung JK, Bauer DE. Therapeutic base editing of human hematopoietic stem cells. Nat Med. 2020 04; 26(4):535-541.

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M?tais JY, Doerfler PA, Mayuranathan T, Bauer DE, Fowler SC, Hsieh MM, Katta V, Keriwala S, Lazzarotto CR, Luk K, Neel MD, Perry SS, Peters ST, Porter SN, Ryu BY, Sharma A, Shea D, Tisdale JF, Uchida N, Wolfe SA, Woodard KJ, Wu Y, Yao Y, Zeng J, Pruett-Miller S, Tsai SQ, Weiss MJ. Genome editing of HBG1 and HBG2 to induce fetal hemoglobin. Blood Adv. 2019 11 12; 3(21):3379-3392.

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Forsberg MH, Foda B, Serreze DV, Chen YG. Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus. Sci Rep. 2019 03 13; 9(1):4316.

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Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP. CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure. J Biol Chem. 2018 11 02; 293(44):17291-17305.

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Liu G. Use of Morpholino Oligomers for Pretargeting. Methods Mol Biol. 2017; 1565:161-179.

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Chen JC, King OD, Zhang Y, Clayton NP, Spencer C, Wentworth BM, Emerson CP, Wagner KR. Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics. Mol Ther. 2016 08; 24(8):1405-11.

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Markert MJ, Zhang Y, Enuameh MS, Reppert SM, Wolfe SA, Merlin C. Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis. G3 (Bethesda). 2016 04 07; 6(4):905-15.

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Koscs? B, Gowda K, Bogunovic M. In vivo depletion and genetic targeting of mouse intestinal CX3CR1(+) mononuclear phagocytes. J Immunol Methods. 2016 May; 432:13-23.

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