Gene Knockout Techniques

"Gene Knockout Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques to alter a gene sequence that result in an inactivated gene, or one in which the expression can be inactivated at a chosen time during development to study the loss of function of a gene.

Descriptor ID	D055786
MeSH Number(s)	E05.393.335.750
Concept/Terms	Gene Knockout Techniques Gene Knockout Techniques Gene Knockout Technique Knockout Technique, Gene Knockout Techniques, Gene Technique, Gene Knockout Techniques, Gene Knockout Gene Knockout Gene Knockouts Knockout, Gene Knockouts, Gene Gene Knock-Out Techniques Gene Knock-Out Technique Knock-Out Technique, Gene Knock-Out Techniques, Gene Technique, Gene Knock-Out Techniques, Gene Knock-Out Gene Knock Out Gene Knock Outs Knock Out, Gene Knock Outs, Gene Out, Gene Knock Outs, Gene Knock Gene Knock Out Techniques

Below are MeSH descriptors whose meaning is more general than "Gene Knockout Techniques".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]
Gene Knockout Techniques [E05.393.335.750]

Below are MeSH descriptors whose meaning is related to "Gene Knockout Techniques".

Below are MeSH descriptors whose meaning is more specific than "Gene Knockout Techniques".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Knockout Techniques" by people in this website by year, and whether "Gene Knockout Techniques" was a major or minor topic of these publications.

Bar chart showing 66 publications over 14 distinct years, with a maximum of 10 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	3	3
2011	3	4	7
2012	1	6	7
2013	0	2	2
2014	1	3	4
2015	1	4	5
2016	0	3	3
2017	0	7	7
2018	0	8	8
2019	0	10	10
2020	0	5	5
2021	0	2	2
2022	0	1	1
2023	0	2	2

Below are the most recent publications written about "Gene Knockout Techniques" by people in Profiles.

Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Molt? PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Manipulating mitochondrial electron flow enhances tumor immunogenicity. Science. 2023 09 22; 381(6664):1316-1323.

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Shin M, Yin HM, Shih YH, Nozaki T, Portman D, Toles B, Kolb A, Luk K, Isogai S, Ishida K, Hanasaka T, Parsons MJ, Wolfe SA, Burns CE, Burns CG, Lawson ND. Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish. Dev Cell. 2023 Nov 20; 58(22):2614-2626.e7.

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Skovs? S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-M?neur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nat Commun. 2022 02 08; 13(1):735.

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Buchwald JE, Martins PN. Designer organs: The future of personalized transplantation. Artif Organs. 2022 Feb; 46(2):180-190.

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Jiang T, S?nchez-Rivera FJ, Soto-Feliciano YM, Yang Q, Song CQ, Bhuatkar A, Haynes CM, Hemann MT, Xue W. Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Hepatology. 2021 07; 74(1):233-247.

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Calvo JA, Fritchman B, Hernandez D, Persky NS, Johannessen CM, Piccioni F, Kelch BA, Cantor SB. Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1. Mol Cancer Res. 2021 06; 19(6):1015-1025.

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Miao X, Sun T, Golan M, Mager J, Cui W. Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice. Mol Reprod Dev. 2020 11; 87(11):1152-1158.

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Awate S, Sommers JA, Datta A, Nayak S, Bellani MA, Yang O, Dunn CA, Nicolae CM, Moldovan GL, Seidman MM, Cantor SB, Brosh RM. FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links. Nucleic Acids Res. 2020 09 18; 48(16):9161-9180.

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Gerbracht JV, Boehm V, Britto-Borges T, Kallabis S, Wiederstein JL, Ciriello S, Aschemeier DU, Kr?ger M, Frese CK, Altm?ller J, Dieterich C, Gehring NH. CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex. Nucleic Acids Res. 2020 09 04; 48(15):8626-8644.

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Cheong A, Archambault D, Degani R, Iverson E, Tremblay KD, Mager J. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development. 2020 05 26; 147(10).

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