Alzheimer Disease

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"Alzheimer Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor ID	D000544
MeSH Number(s)	C10.228.140.380.100 C10.574.945.249 F03.615.400.100
Concept/Terms	Alzheimer Disease Alzheimer Disease Alzheimer's Disease Dementia, Senile Senile Dementia Dementia, Alzheimer Type Alzheimer Type Dementia Alzheimer-Type Dementia (ATD) Alzheimer Type Dementia (ATD) Dementia, Alzheimer-Type (ATD) Alzheimer Type Senile Dementia Primary Senile Degenerative Dementia Dementia, Primary Senile Degenerative Alzheimer Sclerosis Sclerosis, Alzheimer Alzheimer Syndrome Alzheimer Dementia Alzheimer Dementias Dementia, Alzheimer Dementias, Alzheimer Senile Dementia, Alzheimer Type Acute Confusional Senile Dementia Acute Confusional Senile Dementia Senile Dementia, Acute Confusional Dementia, Presenile Dementia, Presenile Presenile Dementia Alzheimer Disease, Late Onset Alzheimer Disease, Late Onset Late Onset Alzheimer Disease Alzheimer's Disease, Focal Onset Alzheimer's Disease, Focal Onset Focal Onset Alzheimer's Disease Familial Alzheimer Disease (FAD) Familial Alzheimer Disease (FAD) Alzheimer Disease, Familial (FAD) Alzheimer Diseases, Familial (FAD) Familial Alzheimer Diseases (FAD) Alzheimer Disease, Early Onset Alzheimer Disease, Early Onset Early Onset Alzheimer Disease Presenile Alzheimer Dementia

Below are MeSH descriptors whose meaning is more general than "Alzheimer Disease".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Dementia [C10.228.140.380]
Alzheimer Disease [C10.228.140.380.100]
Neurodegenerative Diseases [C10.574]
Tauopathies [C10.574.945]
Alzheimer Disease [C10.574.945.249]
Psychiatry and Psychology [F]
Mental Disorders [F03]
Neurocognitive Disorders [F03.615]
Dementia [F03.615.400]
Alzheimer Disease [F03.615.400.100]

Below are MeSH descriptors whose meaning is related to "Alzheimer Disease".

Below are MeSH descriptors whose meaning is more specific than "Alzheimer Disease".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alzheimer Disease" by people in this website by year, and whether "Alzheimer Disease" was a major or minor topic of these publications.

Bar chart showing 649 publications over 31 distinct years, with a maximum of 72 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	6	0	6
1997	2	2	4
1998	2	1	3
1999	8	2	10
2000	3	0	3
2001	10	0	10
2002	4	2	6
2003	2	2	4
2004	6	0	6
2005	7	4	11
2006	9	4	13
2007	14	5	19
2008	9	2	11
2009	14	2	16
2010	14	4	18
2011	11	4	15
2012	18	4	22
2013	16	3	19
2014	14	4	18
2015	7	2	9
2016	14	3	17
2017	22	8	30
2018	22	4	26
2019	33	6	39
2020	40	4	44
2021	43	2	45
2022	49	1	50
2023	47	0	47
2024	66	6	72
2025	42	3	45
2026	10	1	11

Below are the most recent publications written about "Alzheimer Disease" by people in Profiles.

Koops EA, Giudicessi A, Baena A, Martinez L, Bonillas-Felix N, Medrano R, Dutta J, Gonzalez I, Alvarez S, Aguillon D, Quiroz YT, Jacobs HIL. Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2026 Jun; 22(6):e71587.

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Veitch DP, Miller MJ, Kanoria S, Aisen PS, Beckett LA, Green RC, Harvey DJ, Jack CR, Jagust W, Lee EB, Nho K, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Mindt MR, Saykin AJ, Shaw LM, Toga AW, Tosun D, Landau SM, Weiner MW. Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications. Alzheimers Dement. 2026 Jun; 22(6):e71566.

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Jiang X, Hoang TD, Shaw LM, Jacobs DR, Nasrallah IM, Bryan RN, Yaffe K. Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study. Lancet. 2026 May 30; 407(10544):2208-2216.

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Zeamer AL, Lai Y, Loew E, Sanborn V, Tracy M, Jo C, Ferdinand D, Ward DV, Bhattarai SK, Drake J, McCormick BA, Bucci V, Haran JP. Microbiome functional gene pathways are indicative of cognitive performance in older adults at risk for Alzheimer's disease. Gut Microbes. 2026 Dec 31; 18(1):2676162.

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Carbone E, Scibetta S, Cappella M, Crestini A, Perrone F, Hallulli M, Rosa P, Rivabene R, Maiolo F, Simonelli V, Ricceri L, Di Bari MA, De Luca G, Vanacore N, Lacorte E, Piscopo P. A systematic review on the effects of hypercaloric diet in animal models of Alzheimer's disease. J Alzheimers Dis. 2026 07; 112(2):576-610.

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Timsina J, Jiang C, McCartney DL, Tao F, Dalmasso MC, Najar J, Anastasi F, Ohlei O, Puerta Fuentes R, Yang C, Bradley J, Western D, Ali M, Wang C, Yang C, Wu Y, Liu M, Budde J, Williams J, Mahoney R, Castillo Morales A, Hohman TJ, Dumitrescu L, Wang TC, Tesi N, Kern S, Waern M, Skoog I, van Harten A, Pijnenburg YAL, van der Flier WM, S?nchez-Juan P, Rodriguez-Rodriguez E, Kleineidam L, Peters O, Schneider A, K???kali F, Bellenguez C, Grenier-Boley B, Heikkinen S, de Rojas I, Rujescu D, Scherbaum N, Hausner L, D?zel E, Grimmer T, Wiltfang J, Vandenberghe R, Engelborghs S, Heilmann-Heimbach S, Schmid M, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, P?rez-Tur J, Bullido MJ, S?nchez-Valle R, ?lvarez V, Garc?a-Gonz?lez P, Mir P, Real LM, Pi?ol-Ripoll G, Garc?a-Alberca JM, Seelaar H, Ramakers I, Papma J, Hulsman M, Laske C, Teipel S, Priller J, Perneczky R, Buerger K, N?then MM, Lewczuk P, Kornhuber J, Hampel H, Giegling I, Goldhardt O, Diehl-Schmid J, Andrade V, Heneka MM, Fr?lich L, Vogelgsang J, Graff C, Thonberg H, Ullgren A, Papenberg G, Deleuze JF, Dufouil C, Wagner M, Jessen F, Holstege H, van Duijn C, Lebouvier T, Hannon O, Leinonen V, Soininen H, Herukka SK, Giedraitis V, L?wenmark M, Kilander L, Genius P, Rodr?guez B, Luckett ES, Navarro A, Cano A, Marqui? M, Blennow K, Zetterberg H, Lleo A, Boada M, Ruiz A, Lee VM, Van Deerlin VM, Deming Y, Johnson SC, Engelman CD, Pastor P, Alvarez I, Peskind ER, Heslegrave AJ, Saykin AJ, Nho K, Schindler SE, Morris JC, Holtzman DM, McDade E, Renton AE, Goate A, Ibanez L, Riemenschneider M, Albert MS, Laws SM, Porter T, O'Brien EK, Shaw LM, Tijms BM, Ingelsson M, Visser PJ, Hiltunen M, Sleegers K, Ritchie CW, Sims R, Belloy M, Lambert JC, Vilor-Tejedor N, Fern?ndez MV, Li QS, Nagle MW, Marioni RE, Ramirez A, Bertram L, van der Lee SJ, Cruchaga C. GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy. Nat Commun. 2026 Apr 21; 17(1).

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Robinson TL, Montenegro GDC, Fu JF, Pintucci EN, Properzi MJ, Penney DL, Davis R, Sperling RA, Johnson KA, Amariglio RE, Rentz DM. Digital maze test reveals cognitive performance patterns associated with amyloid-? and tau. Neuropsychology. 2026 Jul; 40(5):465-475.

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Qian J, Parner ET, Overgaard M, Betensky RA. Pseudo-observation regression for sequentially truncated data. Biometrics. 2026 Apr 09; 82(2).

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Kanoria S, Veitch DP, Miller MJ, Aisen PS, Beckett LA, Green RC, Harvey DJ, Jack CR, Jagust W, Lee EB, Nho K, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Mindt MR, Saykin AJ, Shaw LM, Toga AW, Tosun D, Landau SM, Weiner MW. Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025). Alzheimers Dement. 2026 Apr; 22(4):e71353.

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Petersen KK, Mil?-Alom? M, Li Y, Du L, Xiong C, Tosun D, Saef B, Saad ZS, Du-Cuny L, Coomaraswamy J, Mordashova Y, Rubel CE, Meyers EA, Shaw LM, Dage JL, Ashton NJ, Zetterberg H, Ferber K, Triana-Baltzer G, Baratta M, Rosenbaugh EG, Cruchaga C, McDade E, Holtzman DM, Morris JC, Sabandal JM, Bateman RJ, Bannon AW, Potter WZ, Schindler SE. Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks. Nat Med. 2026 Mar; 32(3):1085-1094.

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