Alzheimer Disease

"Alzheimer Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Descriptor ID	D000544
MeSH Number(s)	C10.228.140.380.100 C10.574.945.249 F03.615.400.100
Concept/Terms	Alzheimer Disease Alzheimer Disease Alzheimer's Disease Dementia, Senile Senile Dementia Dementia, Alzheimer Type Alzheimer Type Dementia Alzheimer-Type Dementia (ATD) Alzheimer Type Dementia (ATD) Dementia, Alzheimer-Type (ATD) Alzheimer Type Senile Dementia Primary Senile Degenerative Dementia Dementia, Primary Senile Degenerative Alzheimer Sclerosis Sclerosis, Alzheimer Alzheimer Syndrome Alzheimer Dementia Alzheimer Dementias Dementia, Alzheimer Dementias, Alzheimer Senile Dementia, Alzheimer Type Acute Confusional Senile Dementia Acute Confusional Senile Dementia Senile Dementia, Acute Confusional Dementia, Presenile Dementia, Presenile Presenile Dementia Alzheimer Disease, Late Onset Alzheimer Disease, Late Onset Late Onset Alzheimer Disease Alzheimer's Disease, Focal Onset Alzheimer's Disease, Focal Onset Focal Onset Alzheimer's Disease Familial Alzheimer Disease (FAD) Familial Alzheimer Disease (FAD) Alzheimer Disease, Familial (FAD) Alzheimer Diseases, Familial (FAD) Familial Alzheimer Diseases (FAD) Alzheimer Disease, Early Onset Alzheimer Disease, Early Onset Early Onset Alzheimer Disease Presenile Alzheimer Dementia

Below are MeSH descriptors whose meaning is more general than "Alzheimer Disease".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Dementia [C10.228.140.380]
Alzheimer Disease [C10.228.140.380.100]
Neurodegenerative Diseases [C10.574]
Tauopathies [C10.574.945]
Alzheimer Disease [C10.574.945.249]
Psychiatry and Psychology [F]
Mental Disorders [F03]
Neurocognitive Disorders [F03.615]
Dementia [F03.615.400]
Alzheimer Disease [F03.615.400.100]

Below are MeSH descriptors whose meaning is related to "Alzheimer Disease".

Below are MeSH descriptors whose meaning is more specific than "Alzheimer Disease".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alzheimer Disease" by people in this website by year, and whether "Alzheimer Disease" was a major or minor topic of these publications.

Bar chart showing 640 publications over 31 distinct years, with a maximum of 72 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	6	0	6
1997	2	2	4
1998	2	1	3
1999	8	2	10
2000	3	0	3
2001	10	0	10
2002	4	2	6
2003	2	2	4
2004	6	0	6
2005	7	4	11
2006	9	4	13
2007	14	5	19
2008	9	3	12
2009	14	2	16
2010	14	4	18
2011	11	5	16
2012	18	4	22
2013	16	3	19
2014	14	3	17
2015	9	3	12
2016	14	3	17
2017	22	8	30
2018	22	4	26
2019	35	6	41
2020	40	4	44
2021	42	2	44
2022	50	1	51
2023	47	0	47
2024	66	6	72
2025	36	3	39
2026	2	0	2

Below are the most recent publications written about "Alzheimer Disease" by people in Profiles.

Petersen KK, Mil?-Alom? M, Li Y, Du L, Xiong C, Tosun D, Saef B, Saad ZS, Du-Cuny L, Coomaraswamy J, Mordashova Y, Rubel CE, Meyers EA, Shaw LM, Dage JL, Ashton NJ, Zetterberg H, Ferber K, Triana-Baltzer G, Baratta M, Rosenbaugh EG, Cruchaga C, McDade E, Holtzman DM, Morris JC, Sabandal JM, Bateman RJ, Bannon AW, Potter WZ, Schindler SE. Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks. Nat Med. 2026 Mar; 32(3):1085-1094.

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C?novas R, Cox T, Dor? V, Bourgeat P, Fripp J, Feizpour A, Shishegar R, Fowler CJ, Laws SM, Porter T, Rainey-Smith S, Shaw LM, Bateman RJ, Li Y, Vitaliy O, Weiner MW, Morris JC, Benzinger TLS, Schindler SE, Nakamura A, Iwatsubo T, Ikeuchi T, Kato T, Maruff P, Sohrabi HR, Rowe CC, Martins RN, Masters CL, Doecke JD. When Does Alzheimer's Disease Start? Plasma A?42/40 Assays Show Steep Changes at A?-PET Centiloid 15, Mean Age of 66?Years. Ann Neurol. 2026 May; 99(5):1327-1342.

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?zl? S, Dyrba M, Grazia A, Brosseron F, Buerger K, Dechent P, D?zel E, Ewers M, Fliessbach K, Glanz W, Hansen N, Hellmann-Regen J, Hetzer S, Janowitz D, Kilimann I, Kronm?ller M, Laske C, L?sebrink F, Mengel D, Perneczky R, Peters O, Priller J, Ramirez A, Rauchmann BS, Rostamzadeh A, Schneider A, Sodenkamp S, Spottke A, Spruth EJ, Synofzik M, Wiltfang J, Heneka MT, Jessen F, Teipel S. CSF biomarkers of neuroinflammation are associated with regional atrophy. J Neurol. 2025 Dec 24; 273(1):46.

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Tsurumi A, Cahill CM, Liu AJ, Chatterjee P, Das S, Kobayashi A. Development of Plasma Protein Classification Models for Alzheimer's Disease Using Multiple Machine Learning Approaches. Int J Mol Sci. 2025 Dec 02; 26(23).

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Zhang B, McEvoy LK, Nguyen S, Espeland MA, Rapp SR, Horvath S, Lu AT, LaCroix AZ, Nievergelt CM, Maihofer AX, Resnick SM, Mielke MM, Beckman K, Li D, Silver B, Manson JE, Ferrucci L, Shadyab AH. Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease. Alzheimers Dement. 2025 Dec; 21(12):e70983.

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Ravichandran KA, Brosseron F, McManus RM, Ising C, G?rgen S, Schmidt SV, Santarelli F, Lee SY, Jung H, Chung WS, Kim CH, Ruiz Laza A, Ruiz de Almod?var C, Ramirez A, Latz E, Heneka MT. Enhancing Tyro3 signaling ameliorates IL-1? production through STAT1 in Alzheimer's disease models. J Leukoc Biol. 2025 Dec 01; 117(12).

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Brady LS, Mahinrad S, Edelmayer RM, Potter WZ, Hutten SJ, Anticevic A, Taylor-Burds C, Winston CN, Coetzee T, Paulsen JS, Mantua V, Childers EP, Kolb HC, Jack CR, Jagust WJ, Wagner JA, Sivakumaran S, Shaw L, Sharma VM. Beyond Alzheimer's disease-translating biomarker insights across CNS diseases. Sci Transl Med. 2025 Nov 05; 17(823):eadr2511.

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Banerjee A, Yang F, Dutta J, Cacciola A, Hornberger M, Saranathan M. Atrophy patterns of deep gray matter nuclei in Alzheimer's disease and frontotemporal dementia. J Alzheimers Dis. 2025 Dec; 108(4):1760-1777.

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Sheehan PW, Fass SB, Sapkota D, Kang S, Hollis HC, Lawrence JH, Park S, Sharma A, Schafer DP, Anafi RC, Dougherty JD, Fryer JD, Musiek ES. A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging. Nat Neurosci. 2025 Nov; 28(11):2366-2379.

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Bellio TA, Krunic A, Campion MS, Dupaguntla R, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppNL-G-F Mice. Aging Cell. 2025 Nov; 24(11):e70148.

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