Inflammasomes

"Inflammasomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Multiprotein complexes that mediate the activation of CASPASE-1. Dysregulation of inflammasomes has also been linked to a number of autoinflammatory and autoimmune disorders.

Descriptor ID	D058847
MeSH Number(s)	D05.500.224
Concept/Terms	Inflammasomes Inflammasomes Pyroptosomes Inflammasome Pyroptosome

Below are MeSH descriptors whose meaning is more general than "Inflammasomes".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Inflammasomes [D05.500.224]

Below are MeSH descriptors whose meaning is related to "Inflammasomes".

Below are MeSH descriptors whose meaning is more specific than "Inflammasomes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inflammasomes" by people in this website by year, and whether "Inflammasomes" was a major or minor topic of these publications.

Bar chart showing 239 publications over 16 distinct years, with a maximum of 29 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	2	0	2
2011	10	0	10
2012	14	4	18
2013	23	6	29
2014	16	5	21
2015	13	4	17
2016	15	5	20
2017	12	4	16
2018	13	3	16
2019	13	4	17
2020	7	6	13
2021	14	2	16
2022	5	4	9
2023	7	9	16
2024	11	5	16
2025	2	1	3

Below are the most recent publications written about "Inflammasomes" by people in Profiles.

McManus RM, Komes MP, Griep A, Santarelli F, Schwartz S, Ram?n Perea J, Schlachetzki JCM, Bouvier DS, Khalil MA, Lauterbach MA, Heinemann L, Schl?ter T, Pour MS, Lovotti M, Stahl R, Duthie F, Rodr?guez-Alc?zar JF, Schmidt SV, Spitzer J, Noori P, Maillo A, Boettcher A, Herron B, McConville J, Gomez-Cabrero D, Tegn?r J, Glass CK, Hiller K, Latz E, Heneka MT. NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression. Immunity. 2025 Feb 11; 58(2):326-343.e11.

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Lynn T, Kelleher ME, Georges HM, McCauley EM, Logan RW, Yonkers KA, Abrahams VM. Buprenorphine induces human fetal membrane sterile inflammation. J Reprod Immunol. 2025 Mar; 168:104445.

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Ehrens A, Lenz B, Nieto-P?rez C, Latz E, Schmidt FI, Hoerauf A, H?bner MP. Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway. Cell Rep. 2025 Jan 28; 44(1):115164.

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Wang Y, Zhang Y, Kim K, Han J, Okin D, Jiang Z, Yang L, Subramaniam A, Means TK, Nestl? FO, Fitzgerald KA, Randolph GJ, Lesser CF, Kagan JC, Mathis D, Benoist C. A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control. Immunity. 2024 12 10; 57(12):2737-2754.e12.

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Surve D, Fish A, Debnath M, Pinjari A, Lorenzana A, Piya S, Peyton S, Kulkarni A. Sprayable inflammasome-inhibiting lipid nanorods in a polymeric scaffold for psoriasis therapy. Nat Commun. 2024 Oct 19; 15(1):9035.

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Karabag D, Heneka MT, Ising C. The putative contribution of cellular senescence to driving tauopathies. Trends Immunol. 2024 Oct; 45(10):837-848.

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Weiss FD, Alvarez Y, Shakeri F, Sahu A, Leka P, Dernst A, Rollheiser J, Vasconcelos M, Geraci A, Duthie F, Stahl R, Lee HE, Gellner AK, Buness A, Latz E, Meissner F. Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice. Cell Death Differ. 2024 Dec; 31(12):1717-1729.

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Wang W, Dernst A, Martin B, Lorenzi L, Cadefau-Fabregat M, Phulphagar K, Wagener A, Budden C, Stair N, Wagner T, F?rber H, Jaensch A, Stahl R, Duthie F, Schmidt SV, Coll RC, Meissner F, Cuartero S, Latz E, Mangan MSJ. Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation. Cell Rep. 2024 09 24; 43(9):114736.

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Owona BA, Mary A, Messi AN, Ravichandran KA, Mbing JN, Pegnyemb E, Moundipa PF, Heneka MT. Biflavonoid Methylchamaejasmin and Khaya grandifoliola?Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Mol Neurobiol. 2025 Feb; 62(2):1605-1619.

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Taru V, Szabo G, Mehal W, Reiberger T. Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation. J Hepatol. 2024 Nov; 81(5):895-910.

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