An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

Descriptor ID	D000076222
MeSH Number(s)	D05.500.337 D08.811.913.696.620.682.700.931.500 D12.776.476.925.500
Concept/Terms	Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 1 mTORC1 mTORC1 Complex Complex, mTORC1 TORC1 TOR Complex 1 Target of Rapamycin Complex 1

Below are MeSH descriptors whose meaning is more general than "Mechanistic Target of Rapamycin Complex 1".

Below are MeSH descriptors whose meaning is related to "Mechanistic Target of Rapamycin Complex 1".

Below are MeSH descriptors whose meaning is more specific than "Mechanistic Target of Rapamycin Complex 1".