Regulatory-Associated Protein of mTOR

"Regulatory-Associated Protein of mTOR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An adaptor protein component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 that forms stoichiometric complexes with TOR KINASES, which it negatively regulates. It functions as a positive regulator of RIBOSOMAL PROTEIN S6 KINASES.

Descriptor ID	D000076223
MeSH Number(s)	D05.500.337.500 D08.811.913.696.620.682.700.931.500.500 D12.644.360.024.324 D12.776.157.057.157 D12.776.476.024.419 D12.776.476.925.500.500
Concept/Terms	Regulatory-Associated Protein of mTOR Regulatory-Associated Protein of mTOR Regulatory Associated Protein of mTOR mTOR Regulatory-Associated Protein RAPTOR Protein RPTOR Protein

Below are MeSH descriptors whose meaning is more general than "Regulatory-Associated Protein of mTOR".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Mechanistic Target of Rapamycin Complex 1 [D05.500.337]
Regulatory-Associated Protein of mTOR [D05.500.337.500]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
Mechanistic Target of Rapamycin Complex 1 [D08.811.913.696.620.682.700.931.500]
Regulatory-Associated Protein of mTOR [D08.811.913.696.620.682.700.931.500.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Regulatory-Associated Protein of mTOR [D12.644.360.024.324]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Regulatory-Associated Protein of mTOR [D12.776.157.057.157]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Regulatory-Associated Protein of mTOR [D12.776.476.024.419]
TOR Serine-Threonine Kinases [D12.776.476.925]
Mechanistic Target of Rapamycin Complex 1 [D12.776.476.925.500]
Regulatory-Associated Protein of mTOR [D12.776.476.925.500.500]

Below are MeSH descriptors whose meaning is related to "Regulatory-Associated Protein of mTOR".

Below are MeSH descriptors whose meaning is more specific than "Regulatory-Associated Protein of mTOR".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Regulatory-Associated Protein of mTOR" by people in this website by year, and whether "Regulatory-Associated Protein of mTOR" was a major or minor topic of these publications.

Bar chart showing 6 publications over 6 distinct years, with a maximum of 1 publications in 2004 and 2005 and 2012 and 2013 and 2015 and 2016

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2004	1	1
2005	1	1
2012	1	1
2013	1	1
2015	1	1
2016	1	1

Below are the most recent publications written about "Regulatory-Associated Protein of mTOR" by people in Profiles.

Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S. Activation of mTORC1 is essential for ?-adrenergic stimulation of adipose browning. J Clin Invest. 2016 05 02; 126(5):1704-16.

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Venkatesh A, Ma S, Le YZ, Hall MN, R?egg MA, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015 Apr; 125(4):1446-58.

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Miloslavski R, Cohen E, Avraham A, Iluz Y, Hayouka Z, Kasir J, Mudhasani R, Jones SN, Cybulski N, R?egg MA, Larsson O, Gandin V, Rajakumar A, Topisirovic I, Meyuhas O. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. J Mol Cell Biol. 2014 Jun; 6(3):255-66.

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Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity. 2013 Dec 12; 39(6):1043-56.

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Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012 Sep 07; 11(3):429-39.

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Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005 Feb 18; 307(5712):1098-101.

View in: PubMed
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004 Jul 27; 14(14):1296-302.

View in: PubMed

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