Adaptor Proteins, Signal Transducing

"Adaptor Proteins, Signal Transducing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes

Descriptor ID	D048868
MeSH Number(s)	D12.644.360.024 D12.776.157.057 D12.776.476.024
Concept/Terms	Adaptor Proteins, Signal Transducing Adaptor Proteins, Signal Transducing Signal Transducing Adaptor Proteins

Below are MeSH descriptors whose meaning is more general than "Adaptor Proteins, Signal Transducing".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]

Below are MeSH descriptors whose meaning is related to "Adaptor Proteins, Signal Transducing".

Below are MeSH descriptors whose meaning is more specific than "Adaptor Proteins, Signal Transducing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Adaptor Proteins, Signal Transducing" by people in this website by year, and whether "Adaptor Proteins, Signal Transducing" was a major or minor topic of these publications.

Bar chart showing 313 publications over 31 distinct years, with a maximum of 20 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	1	1	2
1997	1	0	1
1998	2	3	5
1999	1	4	5
2000	1	4	5
2001	1	6	7
2002	1	12	13
2003	3	8	11
2004	3	16	19
2005	3	16	19
2006	6	11	17
2007	4	7	11
2008	5	4	9
2009	4	9	13
2010	7	9	16
2011	5	5	10
2012	3	8	11
2013	2	6	8
2014	10	10	20
2015	5	9	14
2016	2	6	8
2017	8	9	17
2018	6	2	8
2019	12	6	18
2020	3	6	9
2021	3	4	7
2022	2	5	7
2023	1	5	6
2024	5	5	10
2025	3	3	6

Below are the most recent publications written about "Adaptor Proteins, Signal Transducing" by people in Profiles.

Peng M, Lee S, Nair HG, MacGilvary N, Cong K, Kraemer M, Li R, McConnell J, Baer C, Deng B, Zhu L, Cantor SB. RAD51 is chromatin enriched and targetable in BRCA1-deficient cells. Mol Cell. 2025 Sep 18; 85(18):3373-3387.e6.

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B?rub? M, Gusscott S, Mao J, Zamberlam G, Boyer A, St-Jean G, Brind'Amour J, Boerboom D. Sustained YAP1 signaling alters the fates of lutein and M?llerian mesenchymal cells in mice. Reproduction. 2025 Aug 01; 170(2).

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Guyer P, Seminova K, Lugar M, Manganaro A, Velarde de la Cruz EE, Hartley R, Smithmyer ME, Speake C, Bonifacio E, Kent SC, James EA. T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes. Diabetologia. 2025 Aug; 68(8):1721-1734.

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Guo S, Hu X, Cotton JL, Ma L, Li Q, Cui J, Wang Y, Thakare RP, Tao Z, Ip YT, Wu X, Wang J, Mao J. VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300. Elife. 2025 May 08; 13.

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Abou Nader N, Jakuc N, Meinsohn MC, Charrier L, Banville L, Brind'Amour J, Paquet M, St-Jean G, Boerboom D, Mao J, P?pin D, Breault DT, Zamberlam G, Boyer A. Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex. Endocrinology. 2025 Apr 22; 166(6).

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Orand T, Delaforge E, Lee A, Kragelj J, Tengo M, Tengo L, Blackledge M, Boeri Erba E, Davis RJ, Palencia A, Jensen MR. Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1. Proc Natl Acad Sci U S A. 2025 Mar 04; 122(9):e2419915122.

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Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 Dec; 20(12):8470-8483.

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Weiss FD, Alvarez Y, Shakeri F, Sahu A, Leka P, Dernst A, Rollheiser J, Vasconcelos M, Geraci A, Duthie F, Stahl R, Lee HE, Gellner AK, Buness A, Latz E, Meissner F. Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice. Cell Death Differ. 2024 Dec; 31(12):1717-1729.

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Mari?o P?rez L, Ielasi FS, Lee A, Delaforge E, Juyoux P, Tengo M, Davis RJ, Palencia A, Jensen MR. Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1. Structure. 2024 09 05; 32(9):1394-1403.e5.

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Guney MH, Nagalekshmi K, McCauley SM, Carbone C, Aydemir O, Luban J. IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2404349121.

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