Cyclin-Dependent Kinases

"Cyclin-Dependent Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.

Descriptor ID	D018844
MeSH Number(s)	D08.811.913.696.620.682.700.646.500 D12.644.360.250 D12.776.167.200 D12.776.476.250
Concept/Terms	Cyclin-Dependent Kinases Cyclin-Dependent Kinases Cyclin Dependent Kinases Cyclin-Dependent Protein Kinases Cyclin Dependent Protein Kinases cdk Proteins

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinases".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinases" by people in this website by year, and whether "Cyclin-Dependent Kinases" was a major or minor topic of these publications.

Bar chart showing 34 publications over 19 distinct years, with a maximum of 6 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	1	2	3
1998	1	0	1
1999	2	0	2
2000	1	0	1
2001	1	1	2
2002	4	2	6
2005	0	1	1
2007	0	2	2
2010	1	0	1
2011	2	1	3
2013	2	0	2
2014	1	2	3
2017	0	1	1
2018	1	0	1
2020	1	0	1
2021	0	1	1
2022	0	1	1
2023	1	0	1

Below are the most recent publications written about "Cyclin-Dependent Kinases" by people in Profiles.

Conti MM, Li R, Narv?ez Ramos MA, Zhu LJ, Fazzio TG, Benanti JA. Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1. Nat Commun. 2023 01 19; 14(1):310.

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Conti MM, Ghizzoni JM, Gil-Bona A, Wang W, Costanzo M, Li R, Flynn MJ, Zhu LJ, Myers CL, Boone C, Andrews BJ, Benanti JA. Repression of essential cell cycle genes increases cellular fitness. PLoS Genet. 2022 08; 18(8):e1010349.

View in: PubMed
Pickering M, Magner M, Keifenheim D, Rhind N. The fission yeast S-phase cyclin Cig2 can drive mitosis. Genetics. 2021 03 03; 217(1):1-12.

View in: PubMed
Bandyopadhyay S, Bhaduri S, ?rd M, Davey NE, Loog M, Pryciak PM. Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In?Vivo. Curr Biol. 2020 11 16; 30(22):4454-4466.e5.

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Repetto MV, Winters MJ, Bush A, Reiter W, Hollenstein DM, Ammerer G, Pryciak PM, Colman-Lerner A. CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5. Mol Cell. 2018 03 15; 69(6):938-952.e6.

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Bahleda R, Grilley-Olson JE, Govindan R, Barlesi F, Greillier L, Perol M, Ray-Coquard I, Strumberg D, Schultheis B, Dy GK, Zalcman G, Weiss GJ, Walter AO, Kornacker M, Rajagopalan P, Henderson D, Nogai H, Ocker M, Soria JC. Phase I dose-escalation studies of roniciclib, a pan-cyclin-dependent kinase inhibitor, in advanced malignancies. Br J Cancer. 2017 Jun 06; 116(12):1505-1512.

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Fan X, Zhou Y, Chen JJ. Role of Cdc6 in re-replication in cells expressing human papillomavirus E7 oncogene. Carcinogenesis. 2016 08; 37(8):799-809.

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Zhang W, Liu Y, Zhao N, Chen H, Qiao L, Zhao W, Chen JJ. Role of Cdk1 in the p53-independent abrogation of the postmitotic checkpoint by human papillomavirus E6. J Virol. 2015 Mar; 89(5):2553-62.

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Pope PA, Bhaduri S, Pryciak PM. Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1. Curr Biol. 2014 Jun 16; 24(12):1390-1396.

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Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD. KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. Oncogene. 2015 Mar 12; 34(11):1432-41.

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