MAP Kinase Kinase Kinases

"MAP Kinase Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).

Descriptor ID	D020930
MeSH Number(s)	D08.811.913.696.620.682.700.559 D12.644.360.400 D12.776.476.400
Concept/Terms	MAP Kinase Kinase Kinases MAP Kinase Kinase Kinases Mitogen-Activated Protein Kinase Kinase Kinases Mitogen Activated Protein Kinase Kinase Kinases Kinases, MAP Kinase Kinase MAP3 Kinases Kinases, MAP3 MAP Kinase Kinase Kinase MAPKKKs MAPK-ERK Kinase Kinases MAPK-ERK Kinase Kinases Kinase Kinases, MAPK-ERK Kinases, MAPK-ERK Kinase MAPK ERK Kinase Kinases MEK Kinases Kinases, MEK MEKKs

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
MAP Kinase Kinase Kinases [D12.644.360.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
MAP Kinase Kinase Kinases [D12.776.476.400]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase Kinases".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase Kinases" by people in this website by year, and whether "MAP Kinase Kinase Kinases" was a major or minor topic of these publications.

Bar chart showing 56 publications over 22 distinct years, with a maximum of 7 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2000	0	1	1
2001	0	1	1
2002	1	1	2
2003	2	2	4
2004	0	1	1
2005	2	5	7
2007	1	4	5
2008	1	1	2
2009	2	0	2
2010	3	1	4
2011	3	2	5
2012	1	0	1
2013	2	2	4
2014	2	0	2
2015	2	0	2
2016	1	2	3
2017	1	1	2
2018	1	1	2
2019	1	1	2
2020	0	2	2

Below are the most recent publications written about "MAP Kinase Kinase Kinases" by people in Profiles.

Li Z, Oh H, Cung M, Marquez SJ, Sun J, Hammad H, Janssens S, Pouliot P, Lambrecht BN, Yang YS, Shim JH, Greenblatt MB. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Biochem Biophys Res Commun. 2020 10 22; 531(4):497-502.

View in: PubMed
Naito MG, Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4959-4970.

View in: PubMed
Newey A, Griffiths B, Michaux J, Pak HS, Stevenson BJ, Woolston A, Semiannikova M, Spain G, Barber LJ, Matthews N, Rao S, Watkins D, Chau I, Coukos G, Racle J, Gfeller D, Starling N, Cunningham D, Bassani-Sternberg M, Gerlinger M. Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment. J Immunother Cancer. 2019 11 18; 7(1):309.

View in: PubMed
Caneo M, Julian V, Byrne AB, Alkema MJ, Calixto A. Diapause induces functional axonal regeneration after necrotic insult in C. elegans. PLoS Genet. 2019 01; 15(1):e1007863.

View in: PubMed
Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 11 30; 362(6418):1064-1069.

View in: PubMed
Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S, Rezai Jahromi B, Khyzha N, DiStefano PV, Suutarinen S, Kiehl TR, Mendes Pereira V, Herman AM, Krings T, Andrade-Barazarte H, Tung T, Valiante T, Zadeh G, Tymianski M, Rauramaa T, Yl?-Herttuala S, Wythe JD, Antonarakis SE, Fr?sen J, Fish JE, Radovanovic I. Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain. N Engl J Med. 2018 01 18; 378(3):250-261.

View in: PubMed
Schwartz AD, Barney LE, Jansen LE, Nguyen TV, Hall CL, Meyer AS, Peyton SR. A biomaterial screening approach reveals microenvironmental mechanisms of drug resistance. Integr Biol (Camb). 2017 Dec 11; 9(12):912-924.

View in: PubMed
Chen L, Paquette N, Mamoor S, Rus F, Nandy A, Leszyk J, Shaffer SA, Silverman N. Innate immune signaling in Drosophila is regulated by transforming growth factor ? (TGF?)-activated kinase (Tak1)-triggered ubiquitin editing. J Biol Chem. 2017 05 26; 292(21):8738-8749.

View in: PubMed
Ramo K, Sugamura K, Craige S, Keaney JF, Davis RJ. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife. 2016 08 09; 5.

View in: PubMed
Min Y, Wi SM, Kang JA, Yang T, Park CS, Park SG, Chung S, Shim JH, Chun E, Lee KY. Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6. Cell Death Dis. 2016 07 28; 7(7):e2313.

View in: PubMed

People

Explore

Similar Concepts

Top Journals