Proto-Oncogene Proteins c-bcr
                             
                            
                            
                                
                                    
                                            
	"Proto-Oncogene Proteins c-bcr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, 
	MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, 
	which enables searching at various levels of specificity.
	
	
		
			
			
				A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
    
			
			
				
				
					
						| Descriptor ID | D051562 | 
					
						| MeSH Number(s) | D08.811.913.696.620.682.700.759 D12.644.360.325.300.099.500 D12.776.476.325.300.099.500 D12.776.624.664.700.171 | 
					
						| Concept/Terms | Proto-Oncogene Proteins c-bcrProto-Oncogene Proteins c-bcrProto Oncogene Proteins c bcrc-bcr, Proto-Oncogene ProteinsProto-Oncogene Protein c-bcrProto Oncogene Protein c bcrc-bcr, Proto-Oncogene ProteinBreakpoint Cluster Region Proteinc-bcr Proteinsc bcr Proteinsc-bcr Proto-Oncogene ProteinsProto-Oncogene Proteins, c-bcrc bcr Proto Oncogene Proteinsbcr Proto-Oncogene ProteinsProto-Oncogene Proteins, bcrbcr Proto Oncogene ProteinsProto-Oncogene Protein bcrProto Oncogene Protein bcr
 | 
					
				
			 
			
				Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-bcr".
				
			 
			
			
				Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-bcr".
				
			 
		 
	 
 
                                        
                                            
	
	
		
			
			
					
				This graph shows the total number of publications written about "Proto-Oncogene Proteins c-bcr" by people in this website by year, and whether "Proto-Oncogene Proteins c-bcr" was a major or minor topic of these publications. 
				
					![]() 
                    To see the data from this visualization as text, 
click here. 
                
			 	
			
			
			
			
				Below are the most recent publications written about "Proto-Oncogene Proteins c-bcr" by people in Profiles.