Protein Kinase C

"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

Descriptor ID	D011493
MeSH Number(s)	D08.811.913.696.620.682.700.725
Concept/Terms	Protein Kinase C Protein Kinase C Calcium-Activated Phospholipid-Dependent Kinase Calcium Activated Phospholipid Dependent Kinase Phospholipid-Dependent Kinase, Calcium-Activated PKC Serine-Threonine Kinase PKC Serine Threonine Kinase Serine-Threonine Kinase, PKC Calcium Phospholipid-Dependent Protein Kinase Calcium Phospholipid Dependent Protein Kinase Phospholipid-Sensitive Calcium-Dependent Protein Kinase Phospholipid Sensitive Calcium Dependent Protein Kinase Protein Kinase M Protein Kinase M

Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Protein Kinase C [D08.811.913.696.620.682.700.725]

Below are MeSH descriptors whose meaning is related to "Protein Kinase C".

Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.

Bar chart showing 78 publications over 24 distinct years, with a maximum of 15 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	1	2
1997	0	2	2
1998	1	2	3
1999	1	1	2
2000	1	1	2
2001	0	2	2
2002	4	2	6
2003	2	1	3
2004	7	8	15
2005	3	2	5
2006	0	1	1
2007	2	2	4
2008	4	1	5
2009	1	2	3
2010	2	0	2
2011	2	2	4
2012	2	2	4
2013	0	2	2
2014	1	2	3
2015	1	2	3
2016	2	0	2
2017	1	0	1
2020	0	1	1
2022	0	1	1

Below are the most recent publications written about "Protein Kinase C" by people in Profiles.

Maeda K, Zachos NC, Orzalli MH, Schmieder SS, Chang D, Bugda Gwilt K, Doucet M, Baetz NW, Lee S, Crawford SE, Estes MK, Kagan JC, Turner JR, Lencer WI. Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell Host Microbe. 2022 02 09; 30(2):216-231.e5.

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Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O'Connor LC, Sitte HH, Melikian HE. Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. J Biol Chem. 2020 04 17; 295(16):5229-5244.

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Levasseur EM, Yamada K, Pi?eros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Oca?a A, Tersey SA, Mirmira RG. Hypusine biosynthesis in ? cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Sci Signal. 2019 12 03; 12(610).

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Ruby MA, Riedl I, Massart J, ?hlin M, Zierath JR. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017 10 01; 313(4):E483-E491.

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Ozay EI, Gonzalez-Perez G, Torres JA, Vijayaraghavan J, Lawlor R, Sherman HL, Garrigan DT, Burnside AS, Osborne BA, Tew GN, Minter LM. Intracellular Delivery of Anti-pPKC? (Thr538) via Protein Transduction Domain Mimics for Immunomodulation. Mol Ther. 2016 Dec; 24(12):2118-2130.

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Najibi M, Labed SA, Visvikis O, Irazoqui JE. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016 05 24; 15(8):1728-42.

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Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Oca?a A. PKC? Is Essential for Pancreatic ?-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016 05; 65(5):1283-96.

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Montgomery MK, Fiveash CE, Braude JP, Osborne B, Brown SH, Mitchell TW, Turner N. Disparate metabolic response to fructose feeding between different mouse strains. Sci Rep. 2015 Dec 22; 5:18474.

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Wu S, Bellve KD, Fogarty KE, Melikian HE. Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15480-5.

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Strachan-Whaley MR, Reilly K, Dobson J, Kalisch BE. Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription. Neurosci Lett. 2015 May 19; 595:54-9.

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