Signal Transduction

"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.

Bar chart showing 2475 publications over 31 distinct years, with a maximum of 149 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	8	11	19
1997	14	9	23
1998	14	20	34
1999	15	27	42
2000	13	24	37
2001	16	26	42
2002	32	56	88
2003	37	40	77
2004	32	62	94
2005	27	61	88
2006	39	50	89
2007	35	72	107
2008	39	61	100
2009	42	68	110
2010	38	91	129
2011	42	81	123
2012	34	91	125
2013	41	99	140
2014	44	105	149
2015	31	98	129
2016	29	89	118
2017	32	75	107
2018	33	62	95
2019	25	73	98
2020	15	54	69
2021	18	50	68
2022	3	24	27
2023	7	22	29
2024	19	27	46
2025	10	45	55
2026	3	15	18

Below are the most recent publications written about "Signal Transduction" by people in Profiles.

Biswas K, Moore C, Rogers H, Wani KA, Mushtaq A, Pukkila-Worley R, Higgins DP, Walker AK, Mullen GP, Rand JB, Francis MM. Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling. Elife. 2026 Jun 08; 14.

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Dhillon BK, Blimkie TM, Idoko OT, Ford R, Angelidou A, Ben-Othman R, Montante S, Amenyogbe N, Dibassey T, Diray-Arce J, Falsafi R, Imam A, McEnaney K, Odumade OA, Ozonoff A, Pomat WS, Richmond PC, Smolen KK, Wariri O, Levy O, van den Biggelaar AHJ, Kampmann B, Kollmann TR, Lee AHY, Hancock REW. Population-specific heterogeneity in ontogeny of the broadly-conserved blood transcriptional program during the first week of life. Nat Commun. 2026 06 01; 17(1).

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Collado-Sole A, Borjini N, Zhai J, Ruiz-Pino F, Soria-Alcaide G, Folgueira C, Garc?a-Vilela C, Romero-de la Rosa B, Lopez V, Zouaghi Y, Jacobs A, Mora-Romero B, Barranco A, Yoldi G, Rizzoti K, Sabio G, Perez-Chacon G, Santamaria PG, Esteban JA, Journiac N, Prevot V, Pascual A, Fern?ndez-Chac?n R, Tena-Sempere M, Pitteloud N, Gonzalez-Suarez E. Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis. Science. 2026 May 21; 392(6800):eaeb6999.

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Weiss GJ, Loftus JC, Mallery DW, Tran NL. Structure-guided identification and biological evaluation of reversible EGFR C797S inhibitors. Sci Rep. 2026 May 04; 16(1).

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Huang L, Liu P, Chen Q, Hu K, Li S, Lee A, Wabitsch M, Zhu LJ, Yu Q, Davis R, Czech MP, Wolfe SA, Wang YX. Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease. Sci Adv. 2026 Apr 24; 12(17):eaed2780.

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Lee JS, Bui QT, Jo M, Morgan JS, Nasa I, Kettenbach AN, Shaw LM. Interaction of IRS2 with PLK1 protects cells from mitotic stress. Cell Death Dis. 2026 Apr 08; 17(1).

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Porto SA, Birdsall GA, Harper NW, Honeywell ME, Leighow SM, Naylor TE, Ward KM, Wesley MK, Pritchard JR, Lee MJ. Genome-wide profiling identifies the genetic dependencies of cell death following EGFR inhibition. J Biol Chem. 2026 May; 302(5):111414.

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Winther KG, Schneider J, Haas G, Christensen AH, Goyal S, Luo W, Wei Z, Liu J, Kj?ge K, Enghild JJ, Meignin C, Silverman N, Cai H, Imler JL, Hartmann R. FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-?B activation in Drosophila melanogaster. EMBO J. 2026 May; 45(9):2965-2990.

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Lee A, Gentzler A, Fitzpatrick D, Raju Ponny S, Aydemir O, Han MS, Lewis CA, Gao G, Davis RJ. Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK. Proc Natl Acad Sci U S A. 2026 Mar 24; 123(12):e2527162123.

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Moyer AJ, Thyme SB. Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish. G3 (Bethesda). 2026 Mar 04; 16(3).

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