Signal Transduction

"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.

Bar chart showing 2399 publications over 31 distinct years, with a maximum of 143 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	7	12	19
1996	8	11	19
1997	14	9	23
1998	14	20	34
1999	15	27	42
2000	13	24	37
2001	15	27	42
2002	32	56	88
2003	37	41	78
2004	32	60	92
2005	25	61	86
2006	39	49	88
2007	35	71	106
2008	38	59	97
2009	41	65	106
2010	37	92	129
2011	41	78	119
2012	33	92	125
2013	40	99	139
2014	43	100	143
2015	30	95	125
2016	28	87	115
2017	32	73	105
2018	30	60	90
2019	23	69	92
2020	15	51	66
2021	18	48	66
2022	3	24	27
2023	6	16	22
2024	17	24	41
2025	8	30	38

Below are the most recent publications written about "Signal Transduction" by people in Profiles.

Murphy KC, DeMarco KD, Zhou L, Peura J, Giwa HK, Lopez-Diaz Y, Ho YJ, Li J, Bai S, Simin K, Zhu LJ, Pitarresi JR, Mercurio AM, Ruscetti M. MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T-cell and Immunotherapy Responses in Prostate Cancer. Cancer Res. 2025 Nov 14; 85(22):4359-4379.

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Chowdhury SR, Parikh CN, Kaur AN, DeMarco KD, Giwa HK, Mishra AK, Murphy KC, Zhou L, Ma B, Ye T, Li J, Liu H, Bai S, Johnson C, Simin K, Pitarresi JR, Zhu LJ, Watson EV, Kelliher MA, Green MR, Fitzgerald KA, Ruscetti M. PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors. Proc Natl Acad Sci U S A. 2025 Sep 30; 122(39):e2514948122.

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Yang YS, Kim MJ, Chaugule S, Mayer E, DeSouza N, Ma H, Xie J, Lee KY, Li S, Gravallese E, Gao G, Shim JH. Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases. Mol Ther. 2025 Dec 03; 33(12):6379-6397.

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Krause K, Franch Arroyo S, Ugolini M, Kueck T, Sullivan TJ, G?lvez EJC, Muenzner M, Goosmann C, Brinkmann V, Frese CK, Alagesan K, Vierbuchen T, Heine H, Resch U, Sander LE, Charpentier E. Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes. EMBO Rep. 2025 Oct; 26(19):4847-4885.

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Surette E, Donahue J, Soto Martinez C, Robinson S, McKenna D, Fitzgerald B, Backus K, Karlstrom RO, Cumplido N, McMenamin SK. Caudal fin shape imprinted during late zebrafish embryogenesis is re-patterned by the Sonic hedgehog pathway. PLoS Biol. 2025 Aug; 23(8):e3003336.

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Karner ER, Wang M, Goel HL, Mercurio AM. GATA3 promotes ferroptosis resistance by repressing integrin ?1 signaling. Proc Natl Acad Sci U S A. 2025 Aug 26; 122(34):e2427304122.

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Gorasiya S, Mushi J, Yoganathan S, Barasa L, Pekson R, Ashby CR, Reznik SE. N,N-Diethylacetamide and N,N-Dipropylacetamide inhibit the NF-kB pathway in in vitro, ex vivo and in vivo models of inflammation-induced preterm birth. Sci Rep. 2025 Aug 14; 15(1):29861.

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Zhan X, Xiao H, Zhang X, Li S, Zhang W, Ma L, Tang J, Meng X. A metallic metabolic nano-regulator reprograms the PKM2/HIF-1a/DLAT axis to amplify tumor-specific cuproptosis. Biomaterials. 2026 Feb; 325:123626.

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B?rub? M, Gusscott S, Mao J, Zamberlam G, Boyer A, St-Jean G, Brind'Amour J, Boerboom D. Sustained YAP1 signaling alters the fates of lutein and M?llerian mesenchymal cells in mice. Reproduction. 2025 Aug 01; 170(2).

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Bergmann A. Cell Death, Compensatory Proliferation, and Cell Competition. Annu Rev Genet. 2025 11; 59(1):165-187.

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