Substrate Specificity

"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Descriptor ID	D013379
MeSH Number(s)	G02.111.835
Concept/Terms	Substrate Specificity Substrate Specificity Specificities, Substrate Specificity, Substrate Substrate Specificities

Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Substrate Specificity [G02.111.835]

Below are MeSH descriptors whose meaning is related to "Substrate Specificity".

Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.

Bar chart showing 242 publications over 31 distinct years, with a maximum of 20 publications in 2007

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1995	8	8
1996	2	2
1997	2	2
1998	5	5
1999	6	6
2000	8	8
2001	3	3
2002	7	7
2003	7	7
2004	7	7
2005	15	15
2006	9	9
2007	20	20
2008	8	8
2009	15	15
2010	13	13
2011	12	12
2012	10	10
2013	14	14
2014	15	15
2015	6	6
2016	8	8
2017	10	10
2018	8	8
2019	10	10
2020	1	1
2021	4	4
2022	1	1
2023	2	2
2024	3	3
2025	3	3

Below are the most recent publications written about "Substrate Specificity" by people in Profiles.

Liu Y, Brown CM, Borges N, Nobre RN, Erramilli S, Belcher Dufrisne M, Kloss B, Giacometti S, Esteves AM, Tim?teo CG, Tokarz P, Cater RJ, Lowary TL, Morita YS, Kossiakoff AA, Santos H, Stansfeld PJ, Nygaard R, Mancia F. Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE. Nat Commun. 2025 Apr 29; 16(1):3974.

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Makhaik S, Rut W, Choudhary S, Upadhyay T, Hao C, Westberg M, Bobst C, Yoo E, Fejzo J, Lin MZ, Bogyo M, Thompson P, Drag M, Hardy JA. A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity. Protein Sci. 2025 Mar; 34(3):e70069.

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Jordano-Raya M, Schrader CE, Ariza RR, Rold?n-Arjona T, C?rdoba-Ca?ero D. Divergent evolution of opposite base specificity and single-stranded DNA activity in animal and plant AP endonucleases. Nucleic Acids Res. 2025 Jan 07; 53(1).

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Azzolino VN, Shaqra AM, Ali A, Kurt Yilmaz N, Schiffer CA. Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance. Viruses. 2024 Sep 05; 16(9).

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Thapa G, Han SR, Paudel P, Kim MS, Hong YS, Oh TJ. In Silico Analysis and Biochemical Characterization of Streptomyces PET Hydrolase with Bis(2-Hydroxyethyl) Terephthalate Biodegradation Activity. J Microbiol Biotechnol. 2024 Sep 28; 34(9):1836-1847.

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Loveland AB, Koh CS, Ganesan R, Jacobson A, Korostelev AA. Structural mechanism of angiogenin activation by the ribosome. Nature. 2024 Jun; 630(8017):769-776.

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Gainetdinov I, Vega-Badillo J, Cecchini K, Bagci A, Colpan C, De D, Bailey S, Arif A, Wu PH, MacRae IJ, Zamore PD. Relaxed targeting rules help PIWI proteins silence transposons. Nature. 2023 Jul; 619(7969):394-402.

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Magrino J, Munford V, Martins DJ, Homma TK, Page B, Gaubitz C, Freire BL, Lerario AM, Vilar JB, Amorin A, Le?o EKE, Kok F, Menck CF, Jorge AA, Kelch BA. A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder. J Biol Chem. 2023 05; 299(5):104656.

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Mahmoud SA, Aldikacti B, Chien P. ATP hydrolysis tunes specificity of a AAA+ protease. Cell Rep. 2022 09 20; 40(12):111405.

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Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. ACS Chem Biol. 2021 11 19; 16(11):2280-2296.

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