Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Sen I, Smith JAB, Caria E, Orlov I, Savikj M, Brady AJ, Lian K, Ellefsen S, Zierath JR, Krook A. Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis. Sci Adv. 2025 Jul 11; 11(28):eads4371.
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Smith JAB, Gabriel BM, Brady AJ, Abdelmoez AM, Savikj M, Wright SC, Koutsilieri S, Barr?s R, Lauschke VM, Krook A, Zierath JR, Pillon NJ. Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis. Mol Metab. 2025 Sep; 99:102200.
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Hunanyan AS, Verma A, Bidzimou MT, Biswas DD, Da Cruz E, Srour MK, Marek J, Hume C, Elmallah MK, Landstrom AP, Mikati MA. Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation. Epilepsia. 2025 Mar; 66(3):899-913.
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Hara T, Asatsu M, Yamagishi T, Ohata C, Funatsu H, Takahashi Y, Shirai M, Nakata C, Katayama H, Kaji T, Fujie T, Yamamoto C. Cadmium Induces Vascular Endothelial Cell Detachment by Downregulating Claudin-5 and ZO-1 Levels. Int J Mol Sci. 2024 Oct 14; 25(20).
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Hu P, Xiao H, Elmore S, Agosto-Burgos C, Hu Y, Hogan SL, Ciavatta DJ, Falk RJ, Jennette JC, Free ME. Regulatory T cells effectively downregulate the autoimmune anti-MPO response and ameliorate anti-MPO induced glomerulonephritis in mice. J Autoimmun. 2024 07; 147:103266.
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Lee S, Jun YW, Linares GR, Butler B, Yuva-Adyemir Y, Moore J, Krishnan G, Ruiz-Juarez B, Santana M, Pons M, Silverman N, Weng Z, Ichida JK, Gao FB. Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD. Neuron. 2023 05 03; 111(9):1381-1390.e6.
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Scheiblich H, Dansokho C, Mercan D, Schmidt SV, Bousset L, Wischhof L, Eikens F, Odainic A, Spitzer J, Griep A, Schwartz S, Bano D, Latz E, Melki R, Heneka MT. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell. 2021 09 30; 184(20):5089-5106.e21.
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Jiang S, Maphis NM, Binder J, Chisholm D, Weston L, Duran W, Peterson C, Zimmerman A, Mandell MA, Jett SD, Bigio E, Geula C, Mellios N, Weick JP, Rosenberg GA, Latz E, Heneka MT, Bhaskar K. Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep. 2021 09 21; 36(12):109720.
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Yang D, Yang H, Luiselli G, Ogagan C, Dai H, Chiu L, Carroll RS, Johnson MD. Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).
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Ai J, Li J, Su Q, Ma H, He R, Wei Q, Li H, Gao G. rAAV-based and intraprostatically delivered miR-34a therapeutics for efficient inhibition of prostate cancer progression. Gene Ther. 2022 08; 29(7-8):418-424.