Epigenesis, Genetic

"Epigenesis, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.

Descriptor ID	D044127
MeSH Number(s)	G05.308.203
Concept/Terms	Epigenesis, Genetic Epigenesis, Genetic Genetic Epigenesis Epigenetic Processes Epigenetic Processes Processes, Epigenetic Epigenetics Processes Processes, Epigenetics Epigenetic Process Process, Epigenetic

Below are MeSH descriptors whose meaning is more general than "Epigenesis, Genetic".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]

Below are MeSH descriptors whose meaning is more specific than "Epigenesis, Genetic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epigenesis, Genetic" by people in this website by year, and whether "Epigenesis, Genetic" was a major or minor topic of these publications.

Bar chart showing 306 publications over 22 distinct years, with a maximum of 28 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	2	3
2006	4	4	8
2007	4	1	5
2008	4	5	9
2009	7	4	11
2010	9	3	12
2011	9	4	13
2012	5	7	12
2013	7	6	13
2014	15	7	22
2015	18	10	28
2016	12	8	20
2017	5	13	18
2018	7	10	17
2019	6	16	22
2020	10	9	19
2021	10	10	20
2022	3	12	15
2023	2	6	8
2024	4	11	15
2025	13	1	14
2026	1	1	2

Below are the most recent publications written about "Epigenesis, Genetic" by people in Profiles.

Chung HK, Liu C, Battu A, Jambor AN, Pratt BM, Xie F, Riesenberg BP, Casillas E, Sun M, Landoni E, Li Y, Ye Q, Joo D, Green J, Syed Z, Brown NJ, Smith M, Ma S, Tan S, Chick B, Tripple V, Wang ZA, Wang J, Mcdonald B, He P, Yang Q, Chen T, Varanasi SK, LaPorta MA, Mann TH, Chen D, Hoffmann F, Ho J, Modliszewski J, Williams A, Liu Y, Wang Z, Liu J, Gao Y, Hu Z, Cho UH, Liu L, Wang Y, Hargreaves DC, Dotti G, Savoldo B, Thaxton JE, Milner JJ, Kaech SM, Wang W. Atlas-guided discovery of transcription factors for T cell programming. Nature. 2026 03; 651(8107):1077-1087.

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Pola-V?liz V, Arredondo SB, Arancibia Y, Ahumada J, Estay S, Vidal N, Haeger PA, Fuenzalida M, Varela-Nallar L, Bustos FJ, Montecino M, van Zundert B. Viral-mediated fluorescent labelling of activated hippocampal memory engrams to study epigenetic dynamics associated with gene expression. Methods. 2026 Mar; 247:85-94.

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Zhang B, McEvoy LK, Nguyen S, Espeland MA, Rapp SR, Horvath S, Lu AT, LaCroix AZ, Nievergelt CM, Maihofer AX, Resnick SM, Mielke MM, Beckman K, Li D, Silver B, Manson JE, Ferrucci L, Shadyab AH. Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease. Alzheimers Dement. 2025 Dec; 21(12):e70983.

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Liu H, Zheng Z, Zhou C, Chen Z, Peng K, Li C, Huang H, Wang L, Liu Y, Li L, Xu S, Li Y, Yang Y, Xiang Y, Zheng J. Photoelectrochemical detection of epigenetic 5-hydroxymethylcytosine based on Cu2O@CuO@Ag and self-triggered isothermal amplification. Anal Chim Acta. 2026 Jan 22; 1384:344968.

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Cashman TJ, Saheera S, Blau AE, Mensah Otabil E, Nagy NY, Samenuk TD, Fitzgibbons TP, McManus DD, Trivedi CM. Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin. JCI Insight. 2025 Sep 09; 10(17).

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Sperber JF, Hart ER, Troller-Renfree SV, Watts TW, Miller M, Bellatin A, Meyer J, Dettmer AM, Champagne FA, Noble KG. Associations among prenatal stress, socioeconomic status, and infant epigenetic aging. Psychoneuroendocrinology. 2025 Oct; 180:107575.

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Jury-Garfe N, S?nchez-Rubio M, Nardocci G, Mercado C, Pe?a-Baeza N, Ruiz-Rudolph P, Montecino M, Varela-Nallar L, van Zundert B. Urban air pollution reduces H3K9me2/me3 in hippocampal and olfactory neurons, correlating with memory and social deficits. Sci Total Environ. 2025 Oct 01; 997:180145.

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Oka T, Smith SS, Oliver-Garcia VS, Lee T, Son HG, Mortaja M, Azin M, Garza-Mayers AC, Huang JT, Nazarian RM, Horn TD, Demehri S. Epigenomic regulation of stemness contributes to the low immunogenicity of the most mutated human cancer. Cell Rep. 2025 May 27; 44(5):115561.

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Yang CH, Rando OJ. Paternal Effects in Mammals: Challenges and Opportunities. Annu Rev Biochem. 2025 06; 94(1):253-278.

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Lardenoije R, Smulders MNCA, Morin EL, Howell BR, Guzman D, Meyer JS, Ressler KJ, S?nchez M, Klengel T. A Cross-Generational Methylomic Signature of Infant Maltreatment in Newborn Rhesus Macaques. Biol Psychiatry. 2025 Nov 15; 98(10):767-778.

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