Epigenesis, Genetic

"Epigenesis, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.

Descriptor ID	D044127
MeSH Number(s)	G05.308.203
Concept/Terms	Epigenesis, Genetic Epigenesis, Genetic Genetic Epigenesis Epigenetic Processes Epigenetic Processes Processes, Epigenetic Epigenetics Processes Processes, Epigenetics Epigenetic Process Process, Epigenetic

Below are MeSH descriptors whose meaning is more general than "Epigenesis, Genetic".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]

Below are MeSH descriptors whose meaning is more specific than "Epigenesis, Genetic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epigenesis, Genetic" by people in this website by year, and whether "Epigenesis, Genetic" was a major or minor topic of these publications.

Bar chart showing 280 publications over 21 distinct years, with a maximum of 26 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	2	3
2006	4	4	8
2007	4	1	5
2008	4	4	8
2009	7	4	11
2010	9	3	12
2011	8	4	12
2012	4	7	11
2013	7	6	13
2014	15	7	22
2015	17	9	26
2016	11	8	19
2017	5	12	17
2018	6	9	15
2019	6	15	21
2020	9	8	17
2021	10	8	18
2022	3	11	14
2023	2	6	8
2024	4	11	15
2025	5	0	5

Below are the most recent publications written about "Epigenesis, Genetic" by people in Profiles.

Cashman TJ, Saheera S, Blau AE, Mensah Otabil E, Nagy NY, Samenuk TD, Fitzgibbons TP, McManus DD, Trivedi CM. Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin. JCI Insight. 2025 Sep 09; 10(17).

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Oka T, Smith SS, Oliver-Garcia VS, Lee T, Son HG, Mortaja M, Azin M, Garza-Mayers AC, Huang JT, Nazarian RM, Horn TD, Demehri S. Epigenomic regulation of stemness contributes to the low immunogenicity of the most mutated human cancer. Cell Rep. 2025 May 27; 44(5):115561.

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Heilbrun EE, Tseitline D, Wasserman H, Kirshenbaum A, Cohen Y, Gordan R, Adar S. The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and repair efficiency. Nucleic Acids Res. 2025 Feb 08; 53(4).

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van Zundert B, Montecino M. Epigenetics in Learning and Memory. Subcell Biochem. 2025; 108:51-71.

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van Zundert B, Montecino M. Epigenetics in Neurodegenerative Diseases. Subcell Biochem. 2025; 108:73-109.

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Katayama M, Nomura K, Mudry JM, Chibalin AV, Krook A, Zierath JR. Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle. Mol Metab. 2025 Feb; 92:102081.

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Bighetti-Trevisan RL, Almeida LO, Ramos JIR, Freitas GP, Oliveira FS, Gordon JAR, Tye CE, Stein GS, Lian JB, Stein JL, Rosa AL, Beloti MM. The effect of osteoclasts on epigenetic regulation by long non-coding RNAs in osteoblasts grown on titanium with nanotopography. Biomater Adv. 2025 Mar; 168:214128.

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Shahzad U, Nikolopoulos M, Li C, Johnston M, Wang JJ, Sabha N, Varn FS, Riemenschneider A, Krumholtz S, Krishnamurthy PM, Smith CA, Karamchandani J, Watts JK, Verhaak RGW, Gallo M, Rutka JT, Das S. CASCADES, a novel SOX2 super-enhancer-associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma. Mol Oncol. 2025 Mar; 19(3):764-784.

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Bonnell VA, Zhang Y, Brown AS, Horton J, Josling GA, Chiu TP, Rohs R, Mahony S, Gord?n R, Llin?s M. DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum. Nucleic Acids Res. 2024 Sep 23; 52(17):10161-10179.

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Wong MM, Hachmer S, Gardner E, Runfola V, Arezza E, Megeney LA, Emerson CP, Gabellini D, Dilworth FJ. SMCHD1 activates the expression of genes required for the expansion of human myoblasts. Nucleic Acids Res. 2024 Sep 09; 52(16):9450-9462.

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