Gene Silencing

"Gene Silencing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

Descriptor ID	D020868
MeSH Number(s)	G05.308.203.374
Concept/Terms	Gene Silencing Gene Silencing Silencing, Gene Gene Inactivation Inactivation, Gene

Below are MeSH descriptors whose meaning is more general than "Gene Silencing".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]

Below are MeSH descriptors whose meaning is related to "Gene Silencing".

Below are MeSH descriptors whose meaning is more specific than "Gene Silencing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Silencing" by people in this website by year, and whether "Gene Silencing" was a major or minor topic of these publications.

Bar chart showing 232 publications over 26 distinct years, with a maximum of 18 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	2	0	2
2001	3	1	4
2002	5	7	12
2003	4	7	11
2004	3	5	8
2005	3	6	9
2006	9	8	17
2007	4	3	7
2008	5	8	13
2009	7	10	17
2010	3	8	11
2011	9	9	18
2012	5	5	10
2013	5	5	10
2014	2	5	7
2015	0	9	9
2016	4	6	10
2017	2	7	9
2018	5	9	14
2019	6	2	8
2020	2	6	8
2021	2	3	5
2022	0	2	2
2023	1	1	2
2024	2	6	8

Below are the most recent publications written about "Gene Silencing" by people in Profiles.

Abajorga M, Yurkovetskiy L, Luban J. piRNA Defense Against Endogenous Retroviruses. Viruses. 2024 Nov 09; 16(11).

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Peterson CL. Heterochromatin: Hiding from the remodeling machines. Mol Cell. 2024 Sep 05; 84(17):3167-3169.

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Allen S, O'Reilly D, Miller R, Sapp E, Summers A, Paquette J, Echeverria Moreno D, Bramato B, McHugh N, Yamada K, Aronin N, DiFiglia M, Khvorova A. mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo. Nucleic Acid Ther. 2024 08; 34(4):164-172.

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Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 Jun 24; 52(11):6099-6113.

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Sarli SL, Fakih HH, Kelly K, Devi G, Rembetsy-Brown JM, McEachern HR, Ferguson CM, Echeverria D, Lee J, Sousa J, Sleiman HF, Khvorova A, Watts JK. Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic Acids Res. 2024 May 22; 52(9):4799-4817.

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Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Res. 2024 May 22; 52(9):5273-5284.

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Ho S, Theurkauf W, Rice N. piRNA-Guided Transposon Silencing and Response to Stress in Drosophila Germline. Viruses. 2024 04 30; 16(5).

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Gupta K, Czerminski JT, Lawrence JB. Trisomy silencing by XIST: translational prospects and challenges. Hum Genet. 2024 Jul; 143(7):843-855.

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Valledor M, Byron M, Dumas B, Carone DM, Hall LL, Lawrence JB. Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing. Cell Rep. 2023 07 25; 42(7):112686.

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Gainetdinov I, Vega-Badillo J, Cecchini K, Bagci A, Colpan C, De D, Bailey S, Arif A, Wu PH, MacRae IJ, Zamore PD. Relaxed targeting rules help PIWI proteins silence transposons. Nature. 2023 Jul; 619(7969):394-402.

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