Gene Silencing

"Gene Silencing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

Descriptor ID	D020868
MeSH Number(s)	G05.308.203.374
Concept/Terms	Gene Silencing Gene Silencing Silencing, Gene Gene Inactivation Inactivation, Gene

Below are MeSH descriptors whose meaning is more general than "Gene Silencing".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]

Below are MeSH descriptors whose meaning is related to "Gene Silencing".

Below are MeSH descriptors whose meaning is more specific than "Gene Silencing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Silencing" by people in this website by year, and whether "Gene Silencing" was a major or minor topic of these publications.

Bar chart showing 254 publications over 28 distinct years, with a maximum of 18 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	3	0	3
2001	3	1	4
2002	5	7	12
2003	4	7	11
2004	3	5	8
2005	3	6	9
2006	9	8	17
2007	4	4	8
2008	6	8	14
2009	7	9	16
2010	3	9	12
2011	9	9	18
2012	5	6	11
2013	7	5	12
2014	2	5	7
2015	1	9	10
2016	4	6	10
2017	2	9	11
2018	5	9	14
2019	6	2	8
2020	3	6	9
2021	3	5	8
2022	0	2	2
2023	1	1	2
2024	2	6	8
2025	2	3	5
2026	3	1	4

Below are the most recent publications written about "Gene Silencing" by people in Profiles.

Larsen EC, Moon JE, King OD, Lawrence JB. Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B. Am J Hum Genet. 2026 Apr 02; 113(4):715-735.

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Ho S, Rice NP, Yu T, Weng Z, Theurkauf WE. Aub, Vasa, and Armi concentration in phase-separated nuage is dispensable for piRNA biogenesis and transposon silencing. RNA. 2026 02 17; 32(3):341-358.

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Fakih HH, Zain Ui Abideen M, Rachid MO, Gross KY, Ormsby TJR, Ross VM, Gagnon R, Dahlke C, Furgal RC, Lochmann C, Summers A, Sleiman HF, F?rst SM, Jackson SN, Gordilho JO, Bouix-Peter C, Portal T, Tang Q, Harris JE, Khvorova A, Blanchard C, Alterman JF. Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model. Nat Commun. 2026 Feb 03; 17(1).

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O'Reilly D, Furgal RC, Ross VM, Luu E, Gross KY, Hariharan V, Summers A, Cooper D, Allen S, Dahlke C, Rachid MO, Chan IL, Fakih HH, Alterman JF, Echeverria D, Watts JK, Khvorova A. Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo. Nucleic Acids Res. 2026 Jan 05; 54(1).

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Fakih HH, Lochmann C, Gagnon R, Summers A, Caiazzi J, Buchwald JE, Tang Q, Maru B, Hildebrand SR, Abideen MZUI, Furgal RC, Gross KY, Yang YS, Cooper D, Monopoli KR, Echeverria D, Shim JH, Yamada K, Alterman JF, Khvorova A. Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs. Nucleic Acids Res. 2025 Nov 26; 53(22).

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Nagaraj H, Jeon T, Cicek YA, Goswami R, Nasim N, Mhaske R, Rotello VM. Efficient Cytosolic Delivery of siRNA Using Lyophilized and Reconstituted Polymer-siRNA Polyplexes. Pharm Res. 2025 Dec; 42(12):2369-2377.

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Weiss A, Gilbert JW, Rivera Flores IV, Belgrad J, Ferguson C, Dogan EO, Wightman N, Mocarski K, Echeverria D, Harkins AL, Summers A, Bramato B, McHugh N, Furgal R, Yamada N, Cooper D, Monopoli K, Godinho BMDC, Hassler MR, Yamada K, Greer P, Henninger N, Brown RH, Khvorova A. RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. Mol Ther. 2025 Aug 06; 33(8):3917-3938.

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Lee SK, Shen W, Wen W, Joo Y, Xue Y, Park A, Qiang A, Su S, Zhang T, Zhang M, Fan J, Zhang Y, De S, Gainetdinov I, Sharov A, Maragkakis M, Wang W. Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development. Cell Rep. 2025 Apr 22; 44(4):115495.

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Yu T, Blyton MBJ, Abajorga M, Koppetsch BS, Ho S, Xu B, Hu Z, Luban J, Chappell K, Weng Z, Theurkauf WE. Evolution of KoRV-A transcriptional silencing in wild koalas. Cell. 2025 Apr 17; 188(8):2081-2093.e16.

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Abajorga M, Yurkovetskiy L, Luban J. piRNA Defense Against Endogenous Retroviruses. Viruses. 2024 11 09; 16(11).

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