Gene Silencing

"Gene Silencing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

Descriptor ID	D020868
MeSH Number(s)	G05.308.203.374
Concept/Terms	Gene Silencing Gene Silencing Silencing, Gene Gene Inactivation Inactivation, Gene

Below are MeSH descriptors whose meaning is more general than "Gene Silencing".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]

Below are MeSH descriptors whose meaning is related to "Gene Silencing".

Below are MeSH descriptors whose meaning is more specific than "Gene Silencing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Silencing" by people in this website by year, and whether "Gene Silencing" was a major or minor topic of these publications.

Bar chart showing 248 publications over 28 distinct years, with a maximum of 18 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	3	0	3
2001	3	1	4
2002	5	7	12
2003	4	7	11
2004	3	5	8
2005	3	6	9
2006	9	8	17
2007	4	4	8
2008	6	8	14
2009	7	9	16
2010	3	9	12
2011	9	9	18
2012	5	5	10
2013	6	5	11
2014	2	5	7
2015	1	9	10
2016	4	6	10
2017	2	9	11
2018	5	9	14
2019	6	2	8
2020	3	6	9
2021	2	5	7
2022	0	2	2
2023	1	1	2
2024	2	6	8
2025	2	3	5
2026	1	0	1

Below are the most recent publications written about "Gene Silencing" by people in Profiles.

Fakih HH, Zain Ui Abideen M, Rachid MO, Gross KY, Ormsby TJR, Ross VM, Gagnon R, Dahlke C, Furgal RC, Lochmann C, Summers A, Sleiman HF, F?rst SM, Jackson SN, Gordilho JO, Bouix-Peter C, Portal T, Tang Q, Harris JE, Khvorova A, Blanchard C, Alterman JF. Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model. Nat Commun. 2026 02 03; 17(1).

View in: PubMed
Fakih HH, Lochmann C, Gagnon R, Summers A, Caiazzi J, Buchwald JE, Tang Q, Maru B, Hildebrand SR, Abideen MZUI, Furgal RC, Gross KY, Yang YS, Cooper D, Monopoli KR, Echeverria D, Shim JH, Yamada K, Alterman JF, Khvorova A. Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs. Nucleic Acids Res. 2025 Nov 26; 53(22).

View in: PubMed
Nagaraj H, Jeon T, Cicek YA, Goswami R, Nasim N, Mhaske R, Rotello VM. Efficient Cytosolic Delivery of siRNA Using Lyophilized and Reconstituted Polymer-siRNA Polyplexes. Pharm Res. 2025 Dec; 42(12):2369-2377.

View in: PubMed
Weiss A, Gilbert JW, Rivera Flores IV, Belgrad J, Ferguson C, Dogan EO, Wightman N, Mocarski K, Echeverria D, Harkins AL, Summers A, Bramato B, McHugh N, Furgal R, Yamada N, Cooper D, Monopoli K, Godinho BMDC, Hassler MR, Yamada K, Greer P, Henninger N, Brown RH, Khvorova A. RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. Mol Ther. 2025 Aug 06; 33(8):3917-3938.

View in: PubMed
Lee SK, Shen W, Wen W, Joo Y, Xue Y, Park A, Qiang A, Su S, Zhang T, Zhang M, Fan J, Zhang Y, De S, Gainetdinov I, Sharov A, Maragkakis M, Wang W. Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development. Cell Rep. 2025 Apr 22; 44(4):115495.

View in: PubMed
Yu T, Blyton MBJ, Abajorga M, Koppetsch BS, Ho S, Xu B, Hu Z, Luban J, Chappell K, Weng Z, Theurkauf WE. Evolution of KoRV-A transcriptional silencing in wild koalas. Cell. 2025 Apr 17; 188(8):2081-2093.e16.

View in: PubMed
Abajorga M, Yurkovetskiy L, Luban J. piRNA Defense Against Endogenous Retroviruses. Viruses. 2024 11 09; 16(11).

View in: PubMed
Peterson CL. Heterochromatin: Hiding from the remodeling machines. Mol Cell. 2024 Sep 05; 84(17):3167-3169.

View in: PubMed
Allen S, O'Reilly D, Miller R, Sapp E, Summers A, Paquette J, Echeverria Moreno D, Bramato B, McHugh N, Yamada K, Aronin N, DiFiglia M, Khvorova A. mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo. Nucleic Acid Ther. 2024 08; 34(4):164-172.

View in: PubMed
Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 Jun 24; 52(11):6099-6113.

View in: PubMed

People

Explore

Similar Concepts

Top Journals