RNA Interference

"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Descriptor ID	D034622
MeSH Number(s)	G05.308.203.374.790
Concept/Terms	RNA Interference RNA Interference Interference, RNA Gene Silencing, Post-Transcriptional Gene Silencing, Post Transcriptional RNA Silencing Post-Transcriptional Gene Silencing Post Transcriptional Gene Silencing Post-Transcriptional Gene Silencings Silencing, Post-Transcriptional Gene RNAi Posttranscriptional Gene Silencing Gene Silencing, Posttranscriptional Gene Silencings, Posttranscriptional Cosuppression Cosuppression Co-Suppression Co Suppression

Below are MeSH descriptors whose meaning is more general than "RNA Interference".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]
RNA Interference [G05.308.203.374.790]

Below are MeSH descriptors whose meaning is related to "RNA Interference".

Below are MeSH descriptors whose meaning is more specific than "RNA Interference".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.

Bar chart showing 481 publications over 25 distinct years, with a maximum of 38 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	11	5	16
2004	20	17	37
2005	17	21	38
2006	10	17	27
2007	11	19	30
2008	6	20	26
2009	6	20	26
2010	5	23	28
2011	9	24	33
2012	6	20	26
2013	4	25	29
2014	7	28	35
2015	4	26	30
2016	4	22	26
2017	6	11	17
2018	4	11	15
2019	5	12	17
2020	0	6	6
2021	0	2	2
2022	0	1	1
2023	0	3	3
2024	2	2	4
2025	2	2	4
2026	1	2	3

Below are the most recent publications written about "RNA Interference" by people in Profiles.

Trampel KA, Gross KY, O'Reilly D, Melisova A, Salman B, Green S, George SA, Khvorova A, Efimov IR, Efimova T. RNAi-mediated p38d silencing mitigates anthracycline cardiotoxicity in female mice. Am J Physiol Heart Circ Physiol. 2026 May 01; 330(5):H1522-H1539.

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Tocheny CE, Buchwald JE, Dahlke CD, Fakih HH, Morgan JS, Summers A, Silva CA, Jackson SO, Lee JS, Card MA, Echeverria D, Peterson C, Mercurio AM, Khvorova A, Shaw LM. Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth. Mol Ther. 2026 May 06; 34(5):2963-2982.

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O'Reilly D, Furgal RC, Ross VM, Luu E, Gross KY, Hariharan V, Summers A, Cooper D, Allen S, Dahlke C, Rachid MO, Chan IL, Fakih HH, Alterman JF, Echeverria D, Watts JK, Khvorova A. Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo. Nucleic Acids Res. 2026 Jan 05; 54(1).

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Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy. Nucleic Acids Res. 2025 Jun 20; 53(12).

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Zhang H, Li X, Song D, Yukselen O, Nanda S, Kucukural A, Li JJ, Garber M, Walhout AJM. Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq. Nat Commun. 2025 May 23; 16(1):4785.

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Weiss A, Gilbert JW, Rivera Flores IV, Belgrad J, Ferguson C, Dogan EO, Wightman N, Mocarski K, Echeverria D, Harkins AL, Summers A, Bramato B, McHugh N, Furgal R, Yamada N, Cooper D, Monopoli K, Godinho BMDC, Hassler MR, Yamada K, Greer P, Henninger N, Brown RH, Khvorova A. RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. Mol Ther. 2025 Aug 06; 33(8):3917-3938.

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Li X, Zhang H, Hodder T, Wang W, Myers CL, Yilmaz LS, Walhout AJM. Systems-level design principles of metabolic rewiring in an animal. Nature. 2025 04; 640(8057):203-211.

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Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 06 24; 52(11):6099-6113.

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Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Res. 2024 05 22; 52(9):5273-5284.

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Tang Q, Khvorova A. RNAi-based drug design: considerations and future directions. Nat Rev Drug Discov. 2024 05; 23(5):341-364.

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