"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
|
| MeSH Number(s) |
G05.308.203.374.790
|
| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
|
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 1 | 2 |
| 2003 | 10 | 5 | 15 |
| 2004 | 20 | 16 | 36 |
| 2005 | 16 | 20 | 36 |
| 2006 | 10 | 17 | 27 |
| 2007 | 10 | 18 | 28 |
| 2008 | 6 | 18 | 24 |
| 2009 | 6 | 19 | 25 |
| 2010 | 5 | 22 | 27 |
| 2011 | 8 | 25 | 33 |
| 2012 | 6 | 18 | 24 |
| 2013 | 3 | 24 | 27 |
| 2014 | 6 | 27 | 33 |
| 2015 | 3 | 24 | 27 |
| 2016 | 4 | 19 | 23 |
| 2017 | 6 | 11 | 17 |
| 2018 | 3 | 11 | 14 |
| 2019 | 5 | 9 | 14 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 3 | 3 |
| 2024 | 2 | 2 | 4 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 Jun 24; 52(11):6099-6113.
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Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Res. 2024 May 22; 52(9):5273-5284.
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Tang Q, Khvorova A. RNAi-based drug design: considerations and future directions. Nat Rev Drug Discov. 2024 05; 23(5):341-364.
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Bakris GL, Saxena M, Gupta A, Chalhoub F, Lee J, Stiglitz D, Makarova N, Goyal N, Guo W, Zappe D, Desai AS. RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024 03 05; 331(9):740-749.
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Desai AS, Webb DJ, Taubel J, Casey S, Cheng Y, Robbie GJ, Foster D, Huang SA, Rhyee S, Sweetser MT, Bakris GL. Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023 Jul 20; 389(3):228-238.
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Khvorova A. siRNAs-A New Class of Medicines. JAMA. 2023 06 27; 329(24):2185-2186.
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Ding YH, Ochoa HJ, Ishidate T, Shirayama M, Mello CC. The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Cell Rep. 2023 05 30; 42(5):112408.
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Tang Q, Sousa J, Echeverria D, Fan X, Hsueh YC, Afshari K, MeHugh N, Cooper DA, Vangjeli L, Monopoli K, Okamura K, Biscans A, Clauss A, Harris JE, Khvorova A. RNAi-based modulation of IFN-? signaling in skin. Mol Ther. 2022 08 03; 30(8):2709-2721.
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Buchwald JE, Martins PN. Designer organs: The future of personalized transplantation. Artif Organs. 2022 Feb; 46(2):180-190.
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Kim H, Ding YH, Zhang G, Yan YH, Conte D, Dong MQ, Mello CC. HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans. Elife. 2021 05 18; 10.