RNA Interference

"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Descriptor ID	D034622
MeSH Number(s)	G05.308.203.374.790
Concept/Terms	RNA Interference RNA Interference Interference, RNA Gene Silencing, Post-Transcriptional Gene Silencing, Post Transcriptional RNA Silencing Post-Transcriptional Gene Silencing Post Transcriptional Gene Silencing Post-Transcriptional Gene Silencings Silencing, Post-Transcriptional Gene RNAi Posttranscriptional Gene Silencing Gene Silencing, Posttranscriptional Gene Silencings, Posttranscriptional Cosuppression Cosuppression Co-Suppression Co Suppression

Below are MeSH descriptors whose meaning is more general than "RNA Interference".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Gene Silencing [G05.308.203.374]
RNA Interference [G05.308.203.374.790]

Below are MeSH descriptors whose meaning is related to "RNA Interference".

Below are MeSH descriptors whose meaning is more specific than "RNA Interference".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.

Bar chart showing 464 publications over 24 distinct years, with a maximum of 38 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	11	5	16
2004	20	16	36
2005	17	21	38
2006	10	17	27
2007	10	18	28
2008	6	20	26
2009	6	20	26
2010	5	22	27
2011	9	24	33
2012	6	19	25
2013	4	24	28
2014	7	27	34
2015	4	24	28
2016	4	21	25
2017	6	11	17
2018	4	11	15
2019	5	10	15
2020	0	4	4
2021	0	2	2
2022	0	1	1
2023	0	3	3
2024	2	2	4
2025	2	2	4

Below are the most recent publications written about "RNA Interference" by people in Profiles.

Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy. Nucleic Acids Res. 2025 Jun 20; 53(12).

View in: PubMed
Zhang H, Li X, Song D, Yukselen O, Nanda S, Kucukural A, Li JJ, Garber M, Walhout AJM. Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq. Nat Commun. 2025 May 23; 16(1):4785.

View in: PubMed
Weiss A, Gilbert JW, Rivera Flores IV, Belgrad J, Ferguson C, Dogan EO, Wightman N, Mocarski K, Echeverria D, Harkins AL, Summers A, Bramato B, McHugh N, Furgal R, Yamada N, Cooper D, Monopoli K, Godinho BMDC, Hassler MR, Yamada K, Greer P, Henninger N, Brown RH, Khvorova A. RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. Mol Ther. 2025 Aug 06; 33(8):3917-3938.

View in: PubMed
Li X, Zhang H, Hodder T, Wang W, Myers CL, Yilmaz LS, Walhout AJM. Systems-level design principles of metabolic rewiring in an animal. Nature. 2025 Apr; 640(8057):203-211.

View in: PubMed
Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 Jun 24; 52(11):6099-6113.

View in: PubMed
Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Res. 2024 May 22; 52(9):5273-5284.

View in: PubMed
Tang Q, Khvorova A. RNAi-based drug design: considerations and future directions. Nat Rev Drug Discov. 2024 05; 23(5):341-364.

View in: PubMed
Bakris GL, Saxena M, Gupta A, Chalhoub F, Lee J, Stiglitz D, Makarova N, Goyal N, Guo W, Zappe D, Desai AS. RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024 03 05; 331(9):740-749.

View in: PubMed
Desai AS, Webb DJ, Taubel J, Casey S, Cheng Y, Robbie GJ, Foster D, Huang SA, Rhyee S, Sweetser MT, Bakris GL. Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023 07 20; 389(3):228-238.

View in: PubMed
Khvorova A. siRNAs-A New Class of Medicines. JAMA. 2023 06 27; 329(24):2185-2186.

View in: PubMed

People

Explore

Similar Concepts

Top Journals