RNA-Induced Silencing Complex
"RNA-Induced Silencing Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).
| Descriptor ID |
D034743
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| MeSH Number(s) |
D08.811.277.352.355.350.810 D08.811.277.352.700.350.810 D12.776.157.725.500.906 D12.776.664.962.500.906
|
| Concept/Terms |
RNA-Induced Silencing Complex- RNA-Induced Silencing Complex
- Complex, RNA-Induced Silencing
- RNA Induced Silencing Complex
- Silencing Complex, RNA-Induced
- RISC Multicomponent Nuclease
- Multicomponent Nuclease, RISC
- Nuclease, RISC Multicomponent
|
Below are MeSH descriptors whose meaning is more general than "RNA-Induced Silencing Complex".
Below are MeSH descriptors whose meaning is more specific than "RNA-Induced Silencing Complex".
This graph shows the total number of publications written about "RNA-Induced Silencing Complex" by people in this website by year, and whether "RNA-Induced Silencing Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 5 | 5 | 10 |
| 2005 | 4 | 1 | 5 |
| 2006 | 0 | 3 | 3 |
| 2007 | 3 | 2 | 5 |
| 2008 | 1 | 4 | 5 |
| 2009 | 2 | 4 | 6 |
| 2010 | 1 | 2 | 3 |
| 2011 | 2 | 2 | 4 |
| 2012 | 1 | 2 | 3 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA-Induced Silencing Complex" by people in Profiles.
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Becker WR, Ober-Reynolds B, Jouravleva K, Jolly SM, Zamore PD, Greenleaf WJ. High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2. Mol Cell. 2019 08 22; 75(4):741-755.e11.
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Haraszti RA, Roux L, Coles AH, Turanov AA, Alterman JF, Echeverria D, Godinho BMDC, Aronin N, Khvorova A. 5?-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo. Nucleic Acids Res. 2017 Jul 27; 45(13):7581-7592.
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Salomon WE, Jolly SM, Moore MJ, Zamore PD, Serebrov V. Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell. 2015 Jul 02; 162(1):84-95.
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Boss? GD, R?egger S, Ow MC, Vasquez-Rifo A, Rondeau EL, Ambros VR, Grosshans H, Simard MJ. The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans. Mol Cell. 2013 Apr 25; 50(2):281-7.
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Flores-Jasso CF, Salomon WE, Zamore PD. Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. RNA. 2013 Feb; 19(2):271-9.
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Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD. Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell. 2012 Nov 21; 151(5):1055-67.
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Karp X, Ambros V. Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans. Development. 2012 Jun; 139(12):2177-86.
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Thivierge C, Makil N, Flamand M, Vasale JJ, Mello CC, Wohlschlegel J, Conte D, Duchaine TF. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011 Dec 18; 19(1):90-7.
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Zhang Z, Xu J, Koppetsch BS, Wang J, Tipping C, Ma S, Weng Z, Theurkauf WE, Zamore PD. Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell. 2011 Nov 18; 44(4):572-84.
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Han BW, Hung JH, Weng Z, Zamore PD, Ameres SL. The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol. 2011 Nov 22; 21(22):1878-87.