Huntingtin Protein

"Huntingtin Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.

Descriptor ID	D000071058
MeSH Number(s)	D12.776.441
Concept/Terms	Huntingtin Protein Huntingtin Protein IT15 Protein Huntington Disease Protein

Below are MeSH descriptors whose meaning is more general than "Huntingtin Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Huntingtin Protein [D12.776.441]

Below are MeSH descriptors whose meaning is related to "Huntingtin Protein".

Below are MeSH descriptors whose meaning is more specific than "Huntingtin Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Huntingtin Protein" by people in this website by year, and whether "Huntingtin Protein" was a major or minor topic of these publications.

Bar chart showing 81 publications over 29 distinct years, with a maximum of 6 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	3	3
1998	0	2	2
1999	0	4	4
2000	0	1	1
2001	0	3	3
2002	0	2	2
2003	0	2	2
2004	0	1	1
2005	0	2	2
2006	0	3	3
2007	0	2	2
2009	0	4	4
2010	0	3	3
2011	0	2	2
2012	0	4	4
2013	0	2	2
2014	0	4	4
2015	0	3	3
2016	3	2	5
2017	2	1	3
2018	6	0	6
2019	4	1	5
2020	2	0	2
2022	0	2	2
2023	0	2	2
2024	1	2	3
2025	2	0	2
2026	2	1	3

Below are the most recent publications written about "Huntingtin Protein" by people in Profiles.

Boudi A, Sapp E, Li YY, Shing K, Kegel-Gleason K, Petrozziello T, Sadri-Vakili G, Aronin N, DiFiglia M, Li X. Early reduction of myelin-associated glycoprotein at myelin membranes in Huntington's disease. Exp Neurol. 2026 Dec; 406:115995.

View in: PubMed
Belgrad J, Summers A, Landles C, Greene JR, Hildebrand S, Knox E, Sapp E, Yamada N, Furgal R, Miller R, Osborne GF, Chase K, Luu E, Freedman J, Bramato B, McHugh N, Nnah I, Benoit V, O'Reilly D, Greer P, Bates GP, Vogt TF, Lee R, Howland D, DiFiglia M, Aronin N, Khvorova A. Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice. Sci Transl Med. 2026 Aug 12; 18(862):eaea3104.

View in: PubMed
Papadopoulou AS, Alterman J, Landles C, Smith EJ, Conroy F, Phillips J, Canibano-Pico M, Nita IM, Osborne GF, Iqbal A, Aldous SG, Bondulich MK, Gomez-Paredes C, Sathasivam K, O'Reilly D, Echeverria D, Bobkov K, Greene JR, Aronin N, Khvorova A, Bates GP. Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model. Sci Transl Med. 2026 Mar 18; 18(841):eadw2495.

View in: PubMed
Mathews EW, Coffey SR, Gärtner A, Belgrad J, Bragg RM, O'Reilly D, Cantle JP, McHugh C, Summers A, Fentz J, Schwagarus T, Cornelius A, Lingos I, Burch Z, Kovalenko M, Andrew MA, Bennett CF, Kordasiewicz HB, Marchionini DM, Wilkinson H, Vogt TF, Beuzer P, Pinto RM, Khvorova A, Howland D, Wheeler VC, Carroll JB. Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding. Nat Commun. 2025 Nov 14; 16(1):10009.

View in: PubMed
Iwanowicz A, Boudi A, Seeley C, Sapp E, Miller R, Liu S, Chase K, Shing K, Batista AR, Siena-Esteves M, Aronin N, DiFiglia M, Kegel-Gleason KB. Intrastriatal Delivery of a Zinc Finger Protein Targeting the Mutant HTT Gene Allele Obviates Lipid Phenotypes in Brain and Plasma in Huntington's Disease Mice. Hum Gene Ther. 2025 08; 36(15-16):1083-1094.

View in: PubMed
Allen S, O'Reilly D, Miller R, Sapp E, Summers A, Paquette J, Echeverria Moreno D, Bramato B, McHugh N, Yamada K, Aronin N, DiFiglia M, Khvorova A. mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo. Nucleic Acid Ther. 2024 08; 34(4):164-172.

View in: PubMed
Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 06 24; 52(11):6099-6113.

View in: PubMed
Belgrad J, Khvorova A. More than 185 CAG repeats: a point of no return in Huntington's disease biology. Brain. 2024 05 03; 147(5):1601-1603.

View in: PubMed
O'Reilly D, Belgrad J, Ferguson C, Summers A, Sapp E, McHugh C, Mathews E, Boudi A, Buchwald J, Ly S, Moreno D, Furgal R, Luu E, Kennedy Z, Hariharan V, Monopoli K, Yang XW, Carroll J, DiFiglia M, Aronin N, Khvorova A. Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease. Mol Ther. 2023 06 07; 31(6):1661-1674.

View in: PubMed
Sapp E, Boudi A, Reid SJ, Trombetta BA, Kivisäkk P, Taghian T, Arnold SE, Howland D, Gray-Edwards H, Kegel-Gleason KB, DiFiglia M. Levels of Synaptic Proteins in Brain and Neurofilament Light Chain in Cerebrospinal Fluid and Plasma of OVT73 Huntington's Disease Sheep Support a Prodromal Disease State. J Huntingtons Dis. 2023; 12(3):201-213.

View in: PubMed

People

Explore

Similar Concepts

Top Journals