DNA-Binding Proteins

"DNA-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Descriptor ID	D004268
MeSH Number(s)	D12.776.260
Concept/Terms	DNA-Binding Proteins DNA-Binding Proteins DNA Binding Proteins DNA Binding Protein Binding Protein, DNA Single-Stranded DNA Binding Proteins Single-Stranded DNA Binding Proteins Single Stranded DNA Binding Proteins SS DNA BP DNA Single-Stranded Binding Protein DNA Single Stranded Binding Protein Single-Stranded DNA-Binding Protein DNA-Binding Protein, Single-Stranded Single Stranded DNA Binding Protein DNA Helix Destabilizing Proteins DNA Helix Destabilizing Proteins

Below are MeSH descriptors whose meaning is more general than "DNA-Binding Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]

Below are MeSH descriptors whose meaning is related to "DNA-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "DNA-Binding Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA-Binding Proteins" by people in this website by year, and whether "DNA-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 903 publications over 31 distinct years, with a maximum of 64 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	14	7	21
1997	14	7	21
1998	20	6	26
1999	25	8	33
2000	18	8	26
2001	19	10	29
2002	35	27	62
2003	21	18	39
2004	42	22	64
2005	34	18	52
2006	17	9	26
2007	16	15	31
2008	17	18	35
2009	16	14	30
2010	15	23	38
2011	20	9	29
2012	26	21	47
2013	22	19	41
2014	21	21	42
2015	27	13	40
2016	16	11	27
2017	10	6	16
2018	15	8	23
2019	13	9	22
2020	20	5	25
2021	8	10	18
2022	3	4	7
2023	0	8	8
2024	6	5	11
2025	9	4	13
2026	1	0	1

Below are the most recent publications written about "DNA-Binding Proteins" by people in Profiles.

Bonilla B, Patty BJ, Sambare SV, Dekker J, Fazzio TG, Hainer SJ. esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions. Genetics. 2026 Apr 04; 232(4).

View in: PubMed
Jun YW, Lee S, Almeida S, Freude KK, Ichida JK, Gao FB. The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD. Nat Commun. 2025 Dec 20; 17(1):1007.

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Jutras BL, Babb K, Jusufovic N, Krusenstjerna AC, Saylor TC, Verma A, Stevenson B. Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry. Curr Protoc. 2025 Nov; 5(11):e70264.

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Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT, Desai RR, Keuss MJ, Barattucci S, Zanovello M, Mehta PR, DeKeyser JM, Limone F, Lee J, Brown AL, Leyton-Jaimes MF, Nash LA, Juan IGS, Aronica E, Wainger BJ, Shah M, Goswami A, Shneider NA, Dickson DW, Burrone J, Zhang C, Wichterle H, Petrucelli L, Watts JK, George AL, Fratta P, Eggan K, Kiskinis E. TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD. Nat Neurosci. 2025 Dec; 28(12):2476-2492.

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Yu C, Wang C, Forman T, Xie J, Major S, Fang MX, Voyer JE, Pogliano J, Fu TM. Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity. Mol Cell. 2025 Nov 20; 85(22):4243-4253.e4.

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Moro N, Fujisawa-Tanaka Y, Watanabe S. ARID1A regulates histone octamer transfer activity of human canonical BAF complex. Nucleic Acids Res. 2025 Sep 23; 53(18).

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Oomen ME, Fox AN, Gonzalez I, Molliex A, Papadopoulou T, Navarro P, Dekker J. Mitotic chromosomes harbor cell type- and species-specific structural features within a universal loop array conformation. Genome Res. 2025 Aug 01; 35(8):1733-1744.

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Zhu W, Zhang Y, Sahay H, Wasserman H, Afek A, Williams J, Shaltz S, Johnson C, Pinheiro K, MacAlpine DM, Weninger KR, Erie DA, Jinks-Robertson S, Gord?n R. DNA mutagenesis driven by transcription factor competition with mismatch repair. Cell. 2025 Oct 02; 188(20):5735-5747.e15.

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Smith JAB, Gabriel BM, Brady AJ, Abdelmoez AM, Savikj M, Wright SC, Koutsilieri S, Barr?s R, Lauschke VM, Krook A, Zierath JR, Pillon NJ. Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis. Mol Metab. 2025 Sep; 99:102200.

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Guo S, Hu X, Cotton JL, Ma L, Li Q, Cui J, Wang Y, Thakare RP, Tao Z, Ip YT, Wu X, Wang J, Mao J. VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300. Elife. 2025 May 08; 13.

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