DNA-Binding Proteins

"DNA-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Descriptor ID	D004268
MeSH Number(s)	D12.776.260
Concept/Terms	DNA-Binding Proteins DNA-Binding Proteins DNA Binding Proteins DNA Binding Protein Binding Protein, DNA Single-Stranded DNA Binding Proteins Single-Stranded DNA Binding Proteins Single Stranded DNA Binding Proteins SS DNA BP DNA Single-Stranded Binding Protein DNA Single Stranded Binding Protein Single-Stranded DNA-Binding Protein DNA-Binding Protein, Single-Stranded Single Stranded DNA Binding Protein DNA Helix Destabilizing Proteins DNA Helix Destabilizing Proteins

Below are MeSH descriptors whose meaning is more general than "DNA-Binding Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]

Below are MeSH descriptors whose meaning is related to "DNA-Binding Proteins".

Below are MeSH descriptors whose meaning is more specific than "DNA-Binding Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA-Binding Proteins" by people in this website by year, and whether "DNA-Binding Proteins" was a major or minor topic of these publications.

Bar chart showing 921 publications over 31 distinct years, with a maximum of 66 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	14	7	21
1997	14	7	21
1998	20	6	26
1999	25	8	33
2000	18	8	26
2001	18	10	28
2002	38	27	65
2003	21	18	39
2004	43	23	66
2005	33	19	52
2006	17	10	27
2007	18	14	32
2008	17	18	35
2009	16	15	31
2010	16	23	39
2011	20	9	29
2012	25	20	45
2013	22	19	41
2014	21	22	43
2015	27	14	41
2016	16	11	27
2017	10	6	16
2018	15	8	23
2019	14	9	23
2020	20	6	26
2021	9	10	19
2022	4	4	8
2023	1	8	9
2024	5	5	10
2025	9	4	13
2026	3	4	7

Below are the most recent publications written about "DNA-Binding Proteins" by people in Profiles.

Smith RG, Fu Y, Schiela KL, Dautle M, Williams RA, Wilson HM, Azadegan C, Whetstine JR, Dekker J, Liu Y. Histone Acetylation Differentially Modulates CTCF-CTCF Loops and Intra-TAD Interactions. Nat Commun. 2026 07 20; 17(1).

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Fluri R, Coll-Tan? M, Brunet T, Cogne B, Conrad S, Nizon M, Nicita F, Travaglini L, Novelli A, Glissmeyer M, Peterson A, Buchan JG, Serber D, Meier K, G?rtner J, Diegmann S, Pingault V, Attie-Bitach T, Courtin T, Schneider MC, Hung W, Sahai I, O'Grady L, Steindl K, Mehta SG, Depienne C, Heron D, Keren B, Heide S, McKee S, Laccone F, Dyer LM, Melver C, Motter C, Jones WD, Wilson ZT, Vats D, Hu? K, Zweier C, Sticht H, Gregor A. De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms. Am J Hum Genet. 2026 Jul 02; 113(7):1543-1557.

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Patel SA, Zhu V, Gerber WK, Suzuki S, Barker C, Hutchinson L, Khedr S, Cachia D, Mangaonkar AA, McGuiness ME, Higgins AW, Miron PM, Gerber JM. Ontogeny and Natural History of Therapy-Related Clonal Hematopoiesis From a Multidisciplinary CHIP Clinic. Am J Hematol. 2026 Aug; 101(8):1915-1927.

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Bledsoe JR, Ferry JA, Li J, Sassoon A, Stonhill MA, Siegele B, Liang X, Dalton J, Mochel MC, Ivashkevich Y, Johari V, Sadigh S, Selove W, Sood S, Ward N, Woda B, Degar B, Feraco AM, Rowe J, Davies K, Al-Ibraheemi A, Amador C, Kovach AE, Fleming MD, Harris MH, Tsai HK. Recurrent SWI/SNF Deficiency Defines a Subset of Peripheral T-Cell Lymphoma With Distinct Clinicopathologic Features. Mod Pathol. 2026 Jul; 39(7):101015.

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Bonilla B, Patty BJ, Sambare SV, Dekker J, Fazzio TG, Hainer SJ. esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions. Genetics. 2026 04 04; 232(4).

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Carulli N, Johnston EE, Klein DC, Verdejo-Torres O, Parikh A, McDaniels A, Rivera A, Quinteros M, Pezacki AT, Chang CJ, Hainer SJ, Padilla-Benavides T. The PBAF chromatin remodeling complex contributes to metal homeostasis through MTF1 regulation. Metallomics. 2026 Jan 31; 18(1).

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Shen Z, Wang C, Fu TM. Supramolecular Assemblies Drive Activation of Inflammasomes. Adv Exp Med Biol. 2026; 1514:41-54.

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Jun YW, Lee S, Almeida S, Freude KK, Ichida JK, Gao FB. The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD. Nat Commun. 2025 Dec 20; 17(1):1007.

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Jutras BL, Babb K, Jusufovic N, Krusenstjerna AC, Saylor TC, Verma A, Stevenson B. Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry. Curr Protoc. 2025 Nov; 5(11):e70264.

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Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT, Desai RR, Keuss MJ, Barattucci S, Zanovello M, Mehta PR, DeKeyser JM, Limone F, Lee J, Brown AL, Leyton-Jaimes MF, Nash LA, Juan IGS, Aronica E, Wainger BJ, Shah M, Goswami A, Shneider NA, Dickson DW, Burrone J, Zhang C, Wichterle H, Petrucelli L, Watts JK, George AL, Fratta P, Eggan K, Kiskinis E. TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD. Nat Neurosci. 2025 Dec; 28(12):2476-2492.

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