NF-kappa B

"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

Descriptor ID	D016328
MeSH Number(s)	D12.776.260.600 D12.776.660.600 D12.776.930.600
Concept/Terms	NF-kappa B NF-kappa B kappa B Enhancer Binding Protein NF-kappaB NF kappaB Transcription Factor NF-kB Factor NF-kB, Transcription NF-kB, Transcription Factor Transcription Factor NF kB NF-kB NF kB Immunoglobulin Enhancer-Binding Protein Enhancer-Binding Protein, Immunoglobulin Immunoglobulin Enhancer Binding Protein Nuclear Factor kappa B Ig-EBP-1 Ig-EBP-1 Ig EBP 1

Below are MeSH descriptors whose meaning is more general than "NF-kappa B".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
NF-kappa B [D12.776.260.600]
Nuclear Proteins [D12.776.660]
NF-kappa B [D12.776.660.600]
Transcription Factors [D12.776.930]
NF-kappa B [D12.776.930.600]

Below are MeSH descriptors whose meaning is related to "NF-kappa B".

Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.

Bar chart showing 373 publications over 31 distinct years, with a maximum of 26 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	1	3
1997	1	4	5
1998	5	2	7
1999	4	5	9
2000	3	6	9
2001	4	9	13
2002	9	14	23
2003	7	11	18
2004	10	16	26
2005	7	12	19
2006	2	8	10
2007	10	13	23
2008	9	11	20
2009	9	12	21
2010	8	9	17
2011	9	10	19
2012	2	10	12
2013	1	19	20
2014	6	10	16
2015	7	14	21
2016	3	7	10
2017	4	7	11
2018	0	12	12
2019	3	4	7
2020	1	2	3
2021	0	5	5
2022	1	1	2
2023	0	3	3
2024	1	3	4
2025	1	2	3
2026	1	1	2

Below are the most recent publications written about "NF-kappa B" by people in Profiles.

Winther KG, Schneider J, Haas G, Christensen AH, Goyal S, Luo W, Wei Z, Liu J, Kj?ge K, Enghild JJ, Meignin C, Silverman N, Cai H, Imler JL, Hartmann R. FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-?B activation in Drosophila melanogaster. EMBO J. 2026 May; 45(9):2965-2990.

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Vafaei A, Kharaghani MA, Shahsavand A, Mohammad Jafari R, Shafaroodi H, Ghasemi M, Dehpour AR. The impact of predator stress on electroshock seizure threshold: insights into GABAergic, glutamatergic, and serotonergic pathways in mice. Behav Brain Funct. 2026 Feb 14; 22(1).

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Gorasiya S, Mushi J, Yoganathan S, Barasa L, Pekson R, Ashby CR, Reznik SE. N,N-Diethylacetamide and N,N-Dipropylacetamide inhibit the NF-kB pathway in in vitro, ex vivo and in vivo models of inflammation-induced preterm birth. Sci Rep. 2025 Aug 14; 15(1):29861.

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Sang-Ngern M, Fukuchi A, Kondratyuk TP, Park EJ, Simmons CJ, Wall MM, Lorch SE, Pezzuto JM, Chang LC. Biologically active withanolides from Physalis peruviana. Pharm Biol. 2025 Dec; 63(1):334-343.

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Go MY, Kim J, Jeon CY, Kim M, Shin DW. Pinitol Improves Lipopolysaccharide-Induced Cellular Damage in Human Dermal Microvascular Endothelial Cells. Molecules. 2025 Mar 28; 30(7).

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Perego M, Yeon M, Agarwal E, Milcarek AT, Bertolini I, Camisaschi C, Ghosh JC, Tang HY, Grandvaux N, Ruscetti M, Kossenkov AV, Preston-Alp S, Tempera I, Auslander N, Altieri DC. Parkin activates innate immunity and promotes antitumor immune responses. J Clin Invest. 2024 08 30; 134(22).

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Qiu Z, Xiang L, Han Y, Zhang B, Qiao X, Zheng Z, Xiao H. Structure-anti-inflammatory activity relationship of garlic fructans in mice with dextran sulfate sodium-induced colitis: Impact of chain length. Carbohydr Polym. 2024 Dec 15; 346:122582.

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Stepien TA, Singletary LA, Guerra FE, Karlinsey JE, Libby SJ, Jaslow SL, Gaggioli MR, Gibbs KD, Ko DC, Brehm MA, Greiner DL, Shultz LD, Fang FC. Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages. mBio. 2024 04 10; 15(4):e0045424.

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Nickenig M, Mangan MSJ, Lee HE, Symeonidis K, Henne A, Kaiser R, Gei?mar E, Garritsen H, Abdullah Z, Hiller K, Latz E, Lauterbach MA. Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. J Immunol. 2024 01 01; 212(1):7-11.

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Liu H, Li N, Kuang G, Gong X, Wang T, Hu J, Du H, Zhong M, Guo J, Xie Y, Xiang Y, Wu S, Yuan Y, Yin X, Wan J, Li K. Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M. Free Radic Biol Med. 2024 01; 210:42-53.

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