Liver X Receptors

"Liver X Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. They have important functions in regulating cholesterol homeostasis, ENERGY METABOLISM; INFLAMMATION; and the immune response.

Descriptor ID	D000071518
MeSH Number(s)	D12.776.260.531 D12.776.826.194
Concept/Terms	Liver X Receptors Liver X Receptors Nuclear Oxysterol Receptors Oxysterol Receptors, Nuclear Liver X Receptor Liver X Receptor Alpha Liver X Receptor Alpha Liver X Receptor-Alpha NR1H3 Protein LXRalpha Protein Nuclear Orphan Receptor LXR-Alpha Nuclear Orphan Receptor LXR Alpha Oxysterols Receptor LXR-Alpha LXR-Alpha, Oxysterols Receptor Oxysterols Receptor LXR Alpha Nuclear Receptor Subfamily 1, Group H, Member 3 LXR-Alpha Protein LXR Alpha Protein Liver X Receptor Beta Liver X Receptor Beta Liver X Receptor-Beta Nuclear Receptor Subfamily 1, Group H, Member 2 Oxysterols Receptor LXR-Beta LXR-Beta, Oxysterols Receptor Oxysterols Receptor LXR Beta LXRbeta Protein NR1H2 Protein

Below are MeSH descriptors whose meaning is more general than "Liver X Receptors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Liver X Receptors [D12.776.260.531]
Receptors, Cytoplasmic and Nuclear [D12.776.826]
Liver X Receptors [D12.776.826.194]

Below are MeSH descriptors whose meaning is related to "Liver X Receptors".

Below are MeSH descriptors whose meaning is more specific than "Liver X Receptors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Liver X Receptors" by people in this website by year, and whether "Liver X Receptors" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2008	1	1
2011	2	2
2015	1	1
2016	1	1
2018	1	1

Below are the most recent publications written about "Liver X Receptors" by people in Profiles.

Reboldi A, Dang E. Cholesterol metabolism in innate and adaptive response. F1000Res. 2018; 7.

View in: PubMed
Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Bj?rkhem I, Gustafsson J?, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, L?tjohann D, Latz E. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sci Transl Med. 2016 Apr 06; 8(333):333ra50.

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Tamehiro N, Park MH, Hawxhurst V, Nagpal K, Adams ME, Zannis VI, Golenbock DT, Fitzgerald ML. LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux. Biochemistry. 2015 Nov 24; 54(46):6931-41.

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Trasino SE, Dawson HD, Urban JF, Wang TT, Solano-Aguilar G. Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high-fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages. J Nutr Biochem. 2013 Nov; 24(11):1931-9.

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Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson J?, Holtzman DM, Heneka MT. Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial A? phagocytosis. J Neurosci. 2011 May 11; 31(19):7049-59.

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Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8.

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Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol. 2008 Apr; 28(7):2187-200.

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