Arun Kumar Somavarapu PhD
| Title | Instructor |
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| Institution | UMass Chan Medical School |
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| Department | Radiology |
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| Address | UMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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| vCard | Download vCard |
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| Institution | T.H. Chan School of Medicine |
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| Department | Radiology |
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Biography
| Technical University of Denmark, Kongens Lyngby, , Denmark | PHD | | |
Bibliographic
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Monti M, Milanetti E, Frans MT, Miotto M, Di Rienzo L, Baranov MV, Gosti G, Somavarapu AK, Nagaraj M, Golbek TW, Rossing E, Moons SJ, Boltje TJ, van den Bogaart G, Weidner T, Otzen DE, Tartaglia GG, Ruocco G, Roeters SJ. Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain. J Phys Chem B. 2024 01 18; 128(2):451-464.
PMID: 38190651.
Citations:
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Somavarapu AK, Kleijwegt G, Nagaraj M, Alam P, Nielsen J, Otzen DE. Drug repurposing screens identify compounds that inhibit a-synuclein oligomers' membrane disruption and block antibody interactions. Chem Sci. 2023 Mar 15; 14(11):3030-3047.
PMID: 36937574.
Citations:
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Farzadfard A, Pedersen JN, Meisl G, Somavarapu AK, Alam P, Goks?yr L, Nielsen MA, Sander AF, Knowles TPJ, Pedersen JS, Otzen DE. The C-terminal tail of a-synuclein protects against aggregate replication but is critical for oligomerization. Commun Biol. 2022 02 10; 5(1):123.
PMID: 35145226.
Citations:
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Otzen DE, Pedersen JN, Somavarapu AK, Clement A, Ji M, Petersen EH, Pedersen JS, Urban S, Schafer NP. Cys-labeling kinetics of membrane protein GlpG: a role for specific SDS binding and micelle changes? Biophys J. 2021 09 21; 120(18):4115-4128.
PMID: 34370995.
Citations:
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Dehury B, Somavarapu AK, Kepp KP. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to ?-secretase. J Struct Biol. 2020 12 01; 212(3):107648.
PMID: 33099014.
Citations:
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van Diggelen F, Frank SA, Somavarapu AK, Scavenius C, Apetri MM, Nielsen J, Tepper AWJW, Enghild JJ, Otzen DE. The interactome of stabilized a-synuclein oligomers and neuronal proteins. FEBS J. 2020 05; 287(10):2037-2054.
PMID: 31686426.
Citations:
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Somavarapu AK, Shen F, Teilum K, Zhang J, Mossin S, Thulstrup PW, Bjerrum MJ, Tiwari MK, Szunyogh D, S?tofte PM, Kepp KP, Hemmingsen L. The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+ -A? Complex. Chemistry. 2017 Oct 04; 23(55):13591-13595.
PMID: 28815875.
Citations:
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Somavarapu AK, Kepp KP. Membrane Dynamics of ?-Secretase Provides a Molecular Basis for ?-Amyloid Binding and Processing. ACS Chem Neurosci. 2017 11 15; 8(11):2424-2436.
PMID: 28841371.
Citations:
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Somavarapu AK, Kepp KP. Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease. J Neurochem. 2016 Apr; 137(1):101-11.
PMID: 26756738.
Citations:
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Somavarapu AK, Kepp KP. The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access. Neurobiol Dis. 2016 May; 89:147-56.
PMID: 26852951.
Citations:
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Nanduri R, Bhutani I, Somavarapu AK, Mahajan S, Parkesh R, Gupta P. ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery. Database (Oxford). 2015; 2015.
PMID: 26637529.
Citations:
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Somavarapu AK, Kepp KP. Direct Correlation of Cell Toxicity to Conformational Ensembles of Genetic A? Variants. ACS Chem Neurosci. 2015 Dec 16; 6(12):1990-6.
PMID: 26447342.
Citations:
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Somavarapu AK, Kepp KP. The Dependence of Amyloid-? Dynamics on Protein Force Fields and Water Models. Chemphyschem. 2015 Oct 26; 16(15):3278-89.
PMID: 26256268.
Citations:
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Dkhar HK, Nanduri R, Mahajan S, Dave S, Saini A, Somavarapu AK, Arora A, Parkesh R, Thakur KG, Mayilraj S, Gupta P. Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: a case of a heterologous and noncanonical ligand-receptor pair. J Immunol. 2014 Jul 01; 193(1):295-305.
PMID: 24907344.
Citations:
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Somavarapu AK, Balakrishnan S, Gautam AK, Palmer DS, Venkatraman P. Structural interrogation of phosphoproteome identified by mass spectrometry reveals allowed and disallowed regions of phosphoconformation. BMC Struct Biol. 2014 Mar 11; 14:9.
PMID: 24618394.
Citations:
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Nanaware PP, Ramteke MP, Somavarapu AK, Venkatraman P. Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance. Proteins. 2014 Jul; 82(7):1283-300.
PMID: 24338975.
Citations:
18 Fields:
Translation:
HumansAnimalsCells
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Ramteke MP, Shelke P, Ramamoorthy V, Somavarapu AK, Gautam AK, Nanaware PP, Karanam S, Mukhopadhyay S, Venkatraman P. Identification of a novel ATPase activity in 14-3-3 proteins--evidence from enzyme kinetics, structure guided modeling and mutagenesis studies. FEBS Lett. 2014 Jan 03; 588(1):71-8.
PMID: 24269678.
Citations:
4 Fields:
Translation:
HumansCells
This graph shows the total number of publications by year. To see the data as text,
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| Year | Publications |
|---|
| 2013 | 1 |
| 2014 | 3 |
| 2015 | 3 |
| 2016 | 2 |
| 2017 | 2 |
| 2019 | 1 |
| 2020 | 1 |
| 2021 | 1 |
| 2022 | 1 |
| 2023 | 1 |
| 2024 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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