Presenilin-1

"Presenilin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.

Descriptor ID	D053764
MeSH Number(s)	D12.776.543.696.500
Concept/Terms	Presenilin-1 Presenilin-1 S182 Protein Presenilin 1

Below are MeSH descriptors whose meaning is more general than "Presenilin-1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Presenilins [D12.776.543.696]
Presenilin-1 [D12.776.543.696.500]

Below are MeSH descriptors whose meaning is related to "Presenilin-1".

Below are MeSH descriptors whose meaning is more specific than "Presenilin-1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Presenilin-1" by people in this website by year, and whether "Presenilin-1" was a major or minor topic of these publications.

Bar chart showing 50 publications over 24 distinct years, with a maximum of 7 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	4	4
1997	0	3	3
1998	0	1	1
1999	0	1	1
2000	0	2	2
2001	0	2	2
2002	0	2	2
2003	0	1	1
2004	0	1	1
2005	0	1	1
2007	4	0	4
2009	0	1	1
2010	3	0	3
2011	0	1	1
2012	4	3	7
2013	1	0	1
2014	1	1	2
2016	2	0	2
2017	2	2	4
2018	0	2	2
2019	1	0	1
2020	0	1	1
2024	0	1	1
2025	1	1	2

Below are the most recent publications written about "Presenilin-1" by people in Profiles.

Villacampa N, Sarlus H, Martorell P, Bhalla K, Gomez-Castro S, Vieira-Saecker A, Slutzkin I, H?ndler K, Venegas C, McManus R, Ulas T, Beyer M, Segal E, Heneka MT. Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer's Disease. ASN Neuro. 2025; 17(1):2506406.

View in: PubMed
Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, Seshadri S, Goate AM, DeStefano AL, Peloso GM. Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project. J Alzheimers Dis. 2025 Apr; 104(3):841-851.

View in: PubMed
Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 Dec; 20(12):8470-8483.

View in: PubMed
Dehury B, Somavarapu AK, Kepp KP. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to ?-secretase. J Struct Biol. 2020 12 01; 212(3):107648.

View in: PubMed
Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. J Biol Chem. 2019 07 19; 294(29):11276-11285.

View in: PubMed
Rogaev EI. Different Pathways to Neurodegeneration. Biochemistry (Mosc). 2018 Sep; 83(9):1007-1008.

View in: PubMed
Franzmeier N, D?zel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Su?rez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero M?, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain. 2018 04 01; 141(4):1186-1200.

View in: PubMed
Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease. Nature. 2017 12 20; 552(7685):355-361.

View in: PubMed
Ofengeim D, Mazzitelli S, Ito Y, DeWitt JP, Mifflin L, Zou C, Das S, Adiconis X, Chen H, Zhu H, Kelliher MA, Levin JZ, Yuan J. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8788-E8797.

View in: PubMed
Somavarapu AK, Kepp KP. Membrane Dynamics of ?-Secretase Provides a Molecular Basis for ?-Amyloid Binding and Processing. ACS Chem Neurosci. 2017 11 15; 8(11):2424-2436.

View in: PubMed

People

Explore

Similar Concepts

Top Journals