Presenilin-1

"Presenilin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.

Descriptor ID	D053764
MeSH Number(s)	D12.776.543.696.500
Concept/Terms	Presenilin-1 Presenilin-1 S182 Protein Presenilin 1

Below are MeSH descriptors whose meaning is more general than "Presenilin-1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Presenilins [D12.776.543.696]
Presenilin-1 [D12.776.543.696.500]

Below are MeSH descriptors whose meaning is related to "Presenilin-1".

Below are MeSH descriptors whose meaning is more specific than "Presenilin-1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Presenilin-1" by people in this website by year, and whether "Presenilin-1" was a major or minor topic of these publications.

Bar chart showing 54 publications over 25 distinct years, with a maximum of 7 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	3	3
1998	0	1	1
1999	0	1	1
2000	0	2	2
2001	0	2	2
2002	0	2	2
2003	0	1	1
2004	0	1	1
2005	0	1	1
2007	4	0	4
2009	0	1	1
2010	3	0	3
2011	0	1	1
2012	4	3	7
2013	1	0	1
2014	1	1	2
2015	0	3	3
2016	2	0	2
2017	2	2	4
2018	0	2	2
2019	2	0	2
2020	0	2	2
2023	0	1	1
2024	0	1	1
2025	1	3	4

Below are the most recent publications written about "Presenilin-1" by people in Profiles.

Villacampa N, Sarlus H, Martorell P, Bhalla K, Castro-Gomez S, Vieira-Saecker A, Slutzkin I, H?ndler K, Venegas C, McManus R, Ulas T, Beyer M, Segal E, Heneka MT. Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer's Disease. ASN Neuro. 2025; 17(1):2506406.

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Cai Y, Wang X, Xiang Y, Wang Z, Long Q, Zeng C. Codonopsis pilosula polysaccharides alleviate neuronal apoptosis induced by endoplasmic reticulum stress-activated PERK-ATF4-CHOP signaling in APP/PS1 mice. J Alzheimers Dis. 2025 Jul; 106(1):317-330.

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Wang MT, Hu ZC, Xiang Y, Zeng XQ, Fei ZC, Chen J, Li XP, Zhu YP, Wang J, Wang YJ, Xu ZQ, Liu YH. Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease. J Prev Alzheimers Dis. 2025 Aug; 12(7):100131.

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Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, Seshadri S, Goate AM, DeStefano AL, Peloso GM. Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project. J Alzheimers Dis. 2025 Apr; 104(3):841-851.

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Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 12; 20(12):8470-8483.

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Wang M, Chen X, Niu L, Xu J, Yu H, Xu X, Yang Q, Xiang Y, Le W. APPswe /PS1?E9 mice exhibit low oxygen saturation and alterations of erythrocytes preceding the neuropathology and cognitive deficiency during Alzheimer's disease. CNS Neurosci Ther. 2023 07; 29(7):1889-1897.

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Dehury B, Somavarapu AK, Kepp KP. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to ?-secretase. J Struct Biol. 2020 12 01; 212(3):107648.

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Wang J, Sun BL, Xiang Y, Tian DY, Zhu C, Li WW, Liu YH, Bu XL, Shen LL, Jin WS, Wang Z, Zeng GH, Xu W, Chen LY, Chen XW, Hu Z, Zhu ZM, Song W, Zhou HD, Yu JT, Wang YJ. Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. Transl Psychiatry. 2020 07 13; 10(1):230.

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Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. J Biol Chem. 2019 07 19; 294(29):11276-11285.

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Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathol Commun. 2019 03 18; 7(1):46.

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