Amyloid beta-Protein Precursor

"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Descriptor ID	D016564
MeSH Number(s)	D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
Concept/Terms	Amyloid beta-Protein Precursor Amyloid beta-Protein Precursor Amyloid beta Protein Precursor beta-Protein Precursor, Amyloid Amyloid beta Precursor Protein Protease Nexin II Nexin II, Protease beta-Amyloid Protein Precursor beta Amyloid Protein Precursor Protease Nexin 2 Nexin 2, Protease Amyloid A4 Protein Precursor Amyloid Protein Precursor

Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Amyloid [D12.776.049]
Amyloidogenic Proteins [D12.776.049.407]
Amyloid beta-Protein Precursor [D12.776.049.407.249]
Membrane Proteins [D12.776.543]
Amyloid beta-Protein Precursor [D12.776.543.039]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Protease Nexins [D12.776.645.468]
Amyloid beta-Protein Precursor [D12.776.645.468.500]
Protein Precursors [D12.776.811]
Amyloid beta-Protein Precursor [D12.776.811.050]

Below are MeSH descriptors whose meaning is related to "Amyloid beta-Protein Precursor".

Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".

Amyloid beta-Protein Precursor
Amyloid beta-Peptides

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.

Bar chart showing 74 publications over 26 distinct years, with a maximum of 7 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	1	2
1999	1	1	2
2000	1	1	2
2001	0	1	1
2002	1	0	1
2003	1	0	1
2005	2	0	2
2006	3	2	5
2007	2	2	4
2008	1	0	1
2009	1	1	2
2010	3	2	5
2011	2	3	5
2012	4	3	7
2013	2	1	3
2014	2	1	3
2015	2	1	3
2016	1	0	1
2017	1	3	4
2018	1	2	3
2019	1	1	2
2020	1	2	3
2021	1	3	4
2023	0	2	2
2024	0	1	1
2025	1	4	5

Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.

Chen BK, Hunsberger HC, Whye A, Matthews LC, Yook A, Willner MJ, Logan RW, Johns S, Weisblum E, Denny CA. Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer's disease. Alzheimers Res Ther. 2025 07 15; 17(1):160.

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Villacampa N, Sarlus H, Martorell P, Bhalla K, Castro-Gomez S, Vieira-Saecker A, Slutzkin I, Händler K, Venegas C, McManus R, Ulas T, Beyer M, Segal E, Heneka MT. Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer's Disease. ASN Neuro. 2025; 17(1):2506406.

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Cai Y, Wang X, Xiang Y, Wang Z, Long Q, Zeng C. Codonopsis pilosula polysaccharides alleviate neuronal apoptosis induced by endoplasmic reticulum stress-activated PERK-ATF4-CHOP signaling in APP/PS1 mice. J Alzheimers Dis. 2025 07; 106(1):317-330.

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Wang MT, Hu ZC, Xiang Y, Zeng XQ, Fei ZC, Chen J, Li XP, Zhu YP, Wang J, Wang YJ, Xu ZQ, Liu YH. Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease. J Prev Alzheimers Dis. 2025 Aug; 12(7):100131.

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Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, Seshadri S, Goate AM, DeStefano AL, Peloso GM. Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project. J Alzheimers Dis. 2025 Apr; 104(3):841-851.

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Abi-Ghanem C, Salinero AE, Smith RM, Kelly RD, Belanger KM, Richard RN, Paul AS, Herzog AA, Thrasher CA, Rybka KA, Riccio D, Gannon OJ, Kordit D, Kyaw NR, Mansour FM, Groom E, Brooks HL, Robison LS, Pumiglia K, Zuloaga DG, Zuloaga KL. Effects of Menopause and High Fat Diet on Metabolic Outcomes in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2024; 101(4):1177-1194.

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Swinford CG, Risacher SL, Vosmeier A, Deardorff R, Chumin EJ, Dzemidzic M, Wu YC, Gao S, McDonald BC, Yoder KK, Unverzagt FW, Wang S, Farlow MR, Brosch JR, Clark DG, Apostolova LG, Sims J, Wang DJ, Saykin AJ. Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer's disease. Neurobiol Aging. 2023 10; 130:103-113.

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Wang M, Chen X, Niu L, Xu J, Yu H, Xu X, Yang Q, Xiang Y, Le W. APPswe /PS1?E9 mice exhibit low oxygen saturation and alterations of erythrocytes preceding the neuropathology and cognitive deficiency during Alzheimer's disease. CNS Neurosci Ther. 2023 07; 29(7):1889-1897.

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Kummer MP, Ising C, Kummer C, Sarlus H, Griep A, Vieira-Saecker A, Schwartz S, Halle A, Brückner M, Händler K, Schultze JL, Beyer M, Latz E, Heneka MT. Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. EMBO J. 2021 12 15; 40(24):e108662.

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Joshi P, Riffel F, Satoh K, Enomoto M, Qamar S, Scheiblich H, Villacampa N, Kumar S, Theil S, Parhizkar S, Haass C, Heneka MT, Fraser PE, St George-Hyslop P, Walter J. Differential interaction with TREM2 modulates microglial uptake of modified A? species. Glia. 2021 12; 69(12):2917-2932.

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