Pore Forming Cytotoxic Proteins

"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.

Descriptor ID	D052899
MeSH Number(s)	D12.776.543.695
Concept/Terms	Pore Forming Cytotoxic Proteins Pore Forming Cytotoxic Proteins

Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Pore Forming Cytotoxic Proteins [D12.776.543.695]

Below are MeSH descriptors whose meaning is related to "Pore Forming Cytotoxic Proteins".

Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.

Bar chart showing 33 publications over 20 distinct years, with a maximum of 5 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2001	0	2	2
2002	0	1	1
2003	0	2	2
2004	0	5	5
2005	0	1	1
2006	0	2	2
2007	2	0	2
2009	2	0	2
2011	3	0	3
2012	1	1	2
2013	1	1	2
2014	1	0	1
2016	1	0	1
2019	1	0	1
2020	1	0	1
2021	1	0	1
2022	0	1	1
2025	1	0	1

Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.

Lan X, Yang M, Wang J, Huang C, Wu A, Cui L, Guo Y, Zeng L, Guo X, Zhang Y, Xiang Y, Wang Q. Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics. Toxins (Basel). 2025 02 06; 17(2).

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Zhou JY, Fitzgerald KA. Hold your horses! Reining in your fastest pores with caspase-7. Immunity. 2022 08 09; 55(8):1340-1342.

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Zhang L, Xue Y, Gopalakrishnan S, Li K, Han Y, Rotello VM. Antimicrobial Peptide-Loaded Pectolite Nanorods for Enhancing Wound-Healing and Biocidal Activity of Titanium. ACS Appl Mater Interfaces. 2021 Jun 23; 13(24):28764-28773.

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Wang Q, Bian X, Zeng L, Pan F, Liu L, Liang J, Wang L, Zhou K, Lee W, Xiang Y, Li S, Teng M, Li X, Guo X, Zhang Y. A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. J Biol Chem. 2020 07 24; 295(30):10293-10306.

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Guo XL, Liu LZ, Wang QQ, Liang JY, Lee WH, Xiang Y, Li SA, Zhang Y. Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation. Commun Biol. 2019; 2:59.

View in: PubMed
Dementiev A, Board J, Sitaram A, Hey T, Kelker MS, Xu X, Hu Y, Vidal-Quist C, Chikwana V, Griffin S, McCaskill D, Wang NX, Hung SC, Chan MK, Lee MM, Hughes J, Wegener A, Aroian RV, Narva KE, Berry C. The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. BMC Biol. 2016 08 30; 14:71.

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Xiang Y, Yan C, Guo X, Zhou K, Li S, Gao Q, Wang X, Zhao F, Liu J, Lee WH, Zhang Y. Host-derived, pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6702-7.

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Los FC, Randis TM, Aroian RV, Ratner AJ. Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev. 2013 Jun; 77(2):173-207.

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Los FC, Ha C, Aroian RV. Neuronal Goa and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins. PLoS One. 2013; 8(1):e54528.

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McKinstry KK, Strutt TM, Kuang Y, Brown DM, Sell S, Dutton RW, Swain SL. Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest. 2012 Aug; 122(8):2847-56.

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