Pore Forming Cytotoxic Proteins

"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.

Descriptor ID	D052899
MeSH Number(s)	D12.776.543.695
Concept/Terms	Pore Forming Cytotoxic Proteins Pore Forming Cytotoxic Proteins

Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Pore Forming Cytotoxic Proteins [D12.776.543.695]

Below are MeSH descriptors whose meaning is related to "Pore Forming Cytotoxic Proteins".

Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.

Bar chart showing 28 publications over 16 distinct years, with a maximum of 5 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2001	0	1	1
2002	0	1	1
2003	0	2	2
2004	0	5	5
2005	0	1	1
2006	0	2	2
2007	2	0	2
2009	2	0	2
2011	3	0	3
2012	1	1	2
2013	1	1	2
2016	1	0	1
2021	1	0	1
2022	0	1	1

Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.

Zhou JY, Fitzgerald KA. Hold your horses! Reining in your fastest pores with caspase-7. Immunity. 2022 08 09; 55(8):1340-1342.

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Zhang L, Xue Y, Gopalakrishnan S, Li K, Han Y, Rotello VM. Antimicrobial Peptide-Loaded Pectolite Nanorods for Enhancing Wound-Healing and Biocidal Activity of Titanium. ACS Appl Mater Interfaces. 2021 Jun 23; 13(24):28764-28773.

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Dementiev A, Board J, Sitaram A, Hey T, Kelker MS, Xu X, Hu Y, Vidal-Quist C, Chikwana V, Griffin S, McCaskill D, Wang NX, Hung SC, Chan MK, Lee MM, Hughes J, Wegener A, Aroian RV, Narva KE, Berry C. The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. BMC Biol. 2016 08 30; 14:71.

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Los FC, Randis TM, Aroian RV, Ratner AJ. Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev. 2013 Jun; 77(2):173-207.

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Los FC, Ha C, Aroian RV. Neuronal Goa and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins. PLoS One. 2013; 8(1):e54528.

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McKinstry KK, Strutt TM, Kuang Y, Brown DM, Sell S, Dutton RW, Swain SL. Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest. 2012 Aug; 122(8):2847-56.

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Silverio JC, Pereira IR, Cipitelli Mda C, Vinagre NF, Rodrigues MM, Gazzinelli RT, Lannes-Vieira J. CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy. PLoS Pathog. 2012; 8(4):e1002645.

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Romano FB, Rossi KC, Savva CG, Holzenburg A, Clerico EM, Heuck AP. Efficient isolation of Pseudomonas aeruginosa type III secretion translocators and assembly of heteromeric transmembrane pores in model membranes. Biochemistry. 2011 Aug 23; 50(33):7117-31.

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Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV. Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog. 2011 Mar; 7(3):e1001314.

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Wang S, Goguen JD, Li F, Lu S. Involvement of CD8+ T cell-mediated immune responses in LcrV DNA vaccine induced protection against lethal Yersinia pestis challenge. Vaccine. 2011 Sep 09; 29(39):6802-9.

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