Dystrophin

"Dystrophin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.

Descriptor ID	D016189
MeSH Number(s)	D12.776.210.500.250 D12.776.220.250 D12.776.543.250
Concept/Terms	Dystrophin Dystrophin

Below are MeSH descriptors whose meaning is more general than "Dystrophin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Contractile Proteins [D12.776.210]
Muscle Proteins [D12.776.210.500]
Dystrophin [D12.776.210.500.250]
Cytoskeletal Proteins [D12.776.220]
Dystrophin [D12.776.220.250]
Membrane Proteins [D12.776.543]
Dystrophin [D12.776.543.250]

Below are MeSH descriptors whose meaning is related to "Dystrophin".

Below are MeSH descriptors whose meaning is more specific than "Dystrophin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dystrophin" by people in this website by year, and whether "Dystrophin" was a major or minor topic of these publications.

Bar chart showing 29 publications over 18 distinct years, with a maximum of 4 publications in 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2004	0	2	2
2006	0	1	1
2010	1	0	1
2011	1	0	1
2012	2	0	2
2013	0	1	1
2014	2	0	2
2015	1	2	3
2016	0	1	1
2017	0	1	1
2019	1	0	1
2020	1	0	1
2021	1	1	2
2022	0	1	1
2023	2	2	4
2024	0	3	3
2025	0	1	1

Below are the most recent publications written about "Dystrophin" by people in Profiles.

Hern?ndez Rodr?guez MY, Biswas DD, Slyne AD, Lee J, Scarrow E, Abdelbarr SM, Daniels H, O'Halloran KD, Ferreira LF, Gersbach CA, ElMallah MK. Respiratory pathology in the mdx/utrn -/- mouse: A murine model for Duchenne Muscular Dystrophy (DMD). PLoS One. 2025; 20(2):e0316295.

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Susorov D, Echeverria D, Khvorova A, Korostelev AA. mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs). Nucleic Acids Res. 2024 Aug 27; 52(15):8687-8701.

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Roger AL, Biswas DD, Huston ML, Le D, Bailey AM, Pucci LA, Shi Y, Robinson-Hamm J, Gersbach CA, ElMallah MK. Respiratory characterization of a humanized Duchenne muscular dystrophy mouse model. Respir Physiol Neurobiol. 2024 08; 326:104282.

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Hart CC, Lee YI, Xie J, Gao G, Lin BL, Hammers DW, Sweeney HL. Potential limitations of microdystrophin gene therapy for Duchenne muscular dystrophy. JCI Insight. 2024 May 07; 9(11).

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Sarker S, Eshaque TB, Soorajkumar A, Nassir N, Zehra B, Kanta SI, Rahaman MA, Islam A, Akter S, Ali MK, Mim RA, Uddin KMF, Chowdhury MSJ, Shams N, Baqui MA, Lim ET, Akter H, Woodbury-Smith M, Uddin M. Mutational spectrum and phenotypic variability of Duchenne muscular dystrophy and related disorders in a Bangladeshi population. Sci Rep. 2023 12 06; 13(1):21547.

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Engelbeen S, O'Reilly D, Van De Vijver D, Verhaart I, van Putten M, Hariharan V, Hassler M, Khvorova A, Damha MJ, Aartsma-Rus A. Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2023 12; 33(6):348-360.

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Lek A, Wong B, Keeler A, Blackwood M, Ma K, Huang S, Sylvia K, Batista AR, Artinian R, Kokoski D, Parajuli S, Putra J, Carreon CK, Lidov H, Woodman K, Pajusalu S, Spinazzola JM, Gallagher T, LaRovere J, Balderson D, Black L, Sutton K, Horgan R, Lek M, Flotte T. Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne's Muscular Dystrophy. N Engl J Med. 2023 09 28; 389(13):1203-1210.

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D'Ambrosio ES, Mendell JR. Evolving Therapeutic Options for the Treatment of Duchenne Muscular Dystrophy. Neurotherapeutics. 2023 Oct; 20(6):1669-1681.

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Mhandire DZ, Burns DP, Roger AL, O'Halloran KD, ElMallah MK. Breathing in Duchenne muscular dystrophy: translation to therapy. J Physiol. 2022 08; 600(15):3465-3482.

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Flotte TR. Precision of Exon Skipping with U7 Constructs. Hum Gene Ther. 2021 11; 32(21-22):1315-1316.

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