alpha 1-Antitrypsin

"alpha 1-Antitrypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.

Descriptor ID	D000515
MeSH Number(s)	D12.644.861.035 D12.776.124.050.070 D12.776.124.790.106.085 D12.776.377.715.085.085 D12.776.395.068 D12.776.872.035
Concept/Terms	alpha 1-Antitrypsin alpha 1-Antitrypsin alpha 1 Antitrypsin alpha 1 Antiprotease Antiprotease, alpha 1 Serpin A1 alpha 1-Protease Inhibitor Inhibitor, alpha 1-Protease alpha 1 Protease Inhibitor alpha 1-Proteinase Inhibitor Inhibitor, alpha 1-Proteinase alpha 1 Proteinase Inhibitor Trypsin Inhibitor, alpha 1-Antitrypsin Trypsin Inhibitor, alpha 1 Antitrypsin A1PI alpha 1-Antiproteinase 1-Antiproteinase, alpha alpha 1 Antiproteinase Prolastin Prolastin Zemaira Zemaira

Below are MeSH descriptors whose meaning is more general than "alpha 1-Antitrypsin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Serpins [D12.644.861]
alpha 1-Antitrypsin [D12.644.861.035]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Acute-Phase Proteins [D12.776.124.050]
alpha 1-Antitrypsin [D12.776.124.050.070]
Serum Globulins [D12.776.124.790]
Alpha-Globulins [D12.776.124.790.106]
alpha 1-Antitrypsin [D12.776.124.790.106.085]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Alpha-Globulins [D12.776.377.715.085]
alpha 1-Antitrypsin [D12.776.377.715.085.085]
Glycoproteins [D12.776.395]
alpha 1-Antitrypsin [D12.776.395.068]
Serpins [D12.776.872]
alpha 1-Antitrypsin [D12.776.872.035]

Below are MeSH descriptors whose meaning is related to "alpha 1-Antitrypsin".

Below are MeSH descriptors whose meaning is more specific than "alpha 1-Antitrypsin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "alpha 1-Antitrypsin" by people in this website by year, and whether "alpha 1-Antitrypsin" was a major or minor topic of these publications.

Bar chart showing 52 publications over 23 distinct years, with a maximum of 7 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2000	0	1	1
2001	1	0	1
2002	2	3	5
2004	2	1	3
2005	1	3	4
2006	4	0	4
2007	2	0	2
2008	2	0	2
2009	1	0	1
2010	1	0	1
2011	2	0	2
2012	3	0	3
2013	2	0	2
2014	1	0	1
2017	6	1	7
2018	4	0	4
2019	1	0	1
2020	1	1	2
2021	1	0	1
2022	2	0	2
2023	0	1	1
2024	1	0	1

Below are the most recent publications written about "alpha 1-Antitrypsin" by people in Profiles.

Pires-Ferreira D, Reil D, Tang Q, Blackwood M, Gallagher T, Keeler AM, Chichester JA, Vyhnal KK, Lindborg JA, Benson J, Fu D, Flotte TR, Gruntman AM. Limb Perfusion Delivery of a rAAV1 Alpha-1 Antitrypsin Vector in Non-Human Primates Is Safe but Insufficient for Therapy. Genes (Basel). 2024 Sep 10; 15(9).

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Pires Ferreira D, Gruntman AM, Flotte TR. Gene therapy for alpha-1 antitrypsin deficiency: an update. Expert Opin Biol Ther. 2023 03; 23(3):283-291.

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Ke H, Guay KP, Flotte TR, Gierasch LM, Gershenson A, Hebert DN. Secretion of functional a1-antitrypsin is cell type dependent: Implications for intramuscular delivery for gene therapy. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2206103119.

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Ghosh AJ, Hobbs BD, Moll M, Saferali A, Boueiz A, Yun JH, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, Lomas D, Castaldi PJ, Carey VJ, DeMeo DL, Cho MH, Silverman EK, Hersh CP. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323.

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Meza-Segura M, Birtley JR, Maldonado-Contreras A, Mueller C, Simin KJ, Stern LJ, McCormick BA. SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant. mBio. 2021 12 21; 12(6):e0283321.

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Ortega VE, Li X, O'Neal WK, Lackey L, Ampleford E, Hawkins GA, Grayeski PJ, Laederach A, Barjaktarevic I, Barr RG, Cooper C, Couper D, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Peters SP, Pirozzi C, Rennard SI, Woodruff PG, Hoffman EA, Meyers DA, Bleecker ER. The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS. Am J Respir Crit Care Med. 2020 03 01; 201(5):540-554.

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Tang Q, Gernoux G, Cheng Y, Flotte T, Mueller C. Engraftment of Human Hepatocytes in the PiZ-NSG Mouse Model. Methods Mol Biol. 2020; 2164:75-85.

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Geiger S, Ozay EI, Geumann U, Hereth MK, Magnusson T, Shanthalingam S, Hirsch D, K?lin S, G?nther C, Osborne BA, Tew GN, Hermann FG, Minter LM. Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD. Mol Ther. 2019 08 07; 27(8):1436-1451.

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Flotte TR. Alpha-1 Antitrypsin Deficiency as a Candidate for Gene Editing. Hum Gene Ther. 2018 08; 29(8):843-844.

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Song CQ, Wang D, Jiang T, O'Connor K, Tang Q, Cai L, Li X, Weng Z, Yin H, Gao G, Mueller C, Flotte TR, Xue W. In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency. Hum Gene Ther. 2018 08; 29(8):853-860.

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