Genetic Therapy

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"Genetic Therapy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

Descriptor ID	D015316
MeSH Number(s)	E02.095.301 E05.393.420.301
Concept/Terms	Genetic Therapy Genetic Therapy Genetic Therapies Therapies, Genetic Therapy, Genetic Therapy, DNA DNA Therapy Genetic Therapy, Somatic Genetic Therapy, Somatic Genetic Therapies, Somatic Somatic Genetic Therapies Somatic Genetic Therapy Therapies, Somatic Genetic Therapy, Somatic Genetic Genetic Therapy, Gametic Genetic Therapy, Gametic Gametic Genetic Therapies Gametic Genetic Therapy Genetic Therapies, Gametic Therapies, Gametic Genetic Therapy, Gametic Genetic Gene Therapy Gene Therapy Therapy, Gene Gene Therapy, Somatic Gene Therapy, Somatic Therapy, Somatic Gene Somatic Gene Therapy

Below are MeSH descriptors whose meaning is more general than "Genetic Therapy".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Biological Therapy [E02.095]
Genetic Therapy [E02.095.301]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Genetic Therapy [E05.393.420.301]

Below are MeSH descriptors whose meaning is more specific than "Genetic Therapy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genetic Therapy" by people in this website by year, and whether "Genetic Therapy" was a major or minor topic of these publications.

Bar chart showing 458 publications over 31 distinct years, with a maximum of 28 publications in 2016 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	3	2	5
1996	3	2	5
1997	5	1	6
1998	3	2	5
1999	5	1	6
2000	7	0	7
2001	6	1	7
2002	13	2	15
2003	11	2	13
2004	10	7	17
2005	15	4	19
2006	8	6	14
2007	16	2	18
2008	17	0	17
2009	11	3	14
2010	9	2	11
2011	10	5	15
2012	3	5	8
2013	11	10	21
2014	13	5	18
2015	17	4	21
2016	21	7	28
2017	18	8	26
2018	13	7	20
2019	13	3	16
2020	15	5	20
2021	6	14	20
2022	6	14	20
2023	5	11	16
2024	19	9	28
2025	2	0	2

Below are the most recent publications written about "Genetic Therapy" by people in Profiles.

Wang J, Poskitt LE, Gallagher J, Puffenberger EG, Wynn RM, Shishodia G, Chuang DT, Beever J, Hardin DL, Brigatti KW, Baker WC, Gately R, Bertrand S, Rodrigues A, Benatti HR, Taghian T, Hall E, Prestigiacomo R, Liang J, Chen G, Zhou X, Ren L, Liu N, He R, Su Q, Xie J, Jiang Z, Gruntman A, Gray-Edwards H, Gao G, Strauss KA, Wang D. BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease. Sci Transl Med. 2025 Feb 26; 17(787):eads0539.

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Laforet GA. Thrombotic Microangiopathy Associated with Systemic Adeno-Associated Virus Gene Transfer: Review of Reported Cases. Hum Gene Ther. 2025 Feb; 36(3-4):64-76.

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Banou L, Sarrafpour S, Teng CC, Liu J. Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions. Yale J Biol Med. 2024 12; 97(4):491-503.

View in: PubMed
Daci R, Gray-Edwards H, Shazeeb MS, Vardar Z, Vachha B, Cataltepe OI, Flotte TR. Neuroimaging Applications for the Delivery and Monitoring of Gene Therapy for Central Nervous System Diseases. Hum Gene Ther. 2024 Nov; 35(21-22):886-895.

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Wang JH, Zhan W, Gallagher TL, Gao G. Recombinant adeno-associated virus as a delivery platform for ocular gene therapy: A comprehensive review. Mol Ther. 2024 Dec 04; 32(12):4185-4207.

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Du A, Yang K, Zhou X, Ren L, Liu N, Zhou C, Liang J, Yan N, Gao G, Wang D. Systemic gene therapy corrects the neurological phenotype in a mouse model of NGLY1 deficiency. JCI Insight. 2024 Oct 08; 9(19).

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Mo W, Donahue JK. Gene therapy for atrial fibrillation. J Mol Cell Cardiol. 2024 Nov; 196:84-93.

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Pires-Ferreira D, Reil D, Tang Q, Blackwood M, Gallagher T, Keeler AM, Chichester JA, Vyhnal KK, Lindborg JA, Benson J, Fu D, Flotte TR, Gruntman AM. Limb Perfusion Delivery of a rAAV1 Alpha-1 Antitrypsin Vector in Non-Human Primates Is Safe but Insufficient for Therapy. Genes (Basel). 2024 Sep 10; 15(9).

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Benatti HR, Anagnostakou V, Taghian T, Hall EF, Nath S, Heilman CB, Beneduce BM, Leporati A, Raskett C, Epshtein M, King R, Gounis MJ, Malek AM, Gray-Edwards HL. A minimally invasive endovascular approach to the cerebellopontine angle cistern enables broad CNS biodistribution of scAAV9-CB-GFP. Mol Ther. 2024 Oct 02; 32(10):3346-3355.

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Harkins AL, Ambegaokar PP, Keeler AM. Immune responses to central nervous system directed adeno-associated virus gene therapy: Does direct CNS delivery make a difference? Neurotherapeutics. 2024 Jul; 21(4):e00435.

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