Genetic Therapy

"Genetic Therapy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

Descriptor ID	D015316
MeSH Number(s)	E02.095.301 E05.393.420.301
Concept/Terms	Genetic Therapy Genetic Therapy Genetic Therapies Therapies, Genetic Therapy, Genetic Therapy, DNA DNA Therapy Genetic Therapy, Somatic Genetic Therapy, Somatic Genetic Therapies, Somatic Somatic Genetic Therapies Somatic Genetic Therapy Therapies, Somatic Genetic Therapy, Somatic Genetic Genetic Therapy, Gametic Genetic Therapy, Gametic Gametic Genetic Therapies Gametic Genetic Therapy Genetic Therapies, Gametic Therapies, Gametic Genetic Therapy, Gametic Genetic Gene Therapy Gene Therapy Therapy, Gene Gene Therapy, Somatic Gene Therapy, Somatic Therapy, Somatic Gene Somatic Gene Therapy

Below are MeSH descriptors whose meaning is more general than "Genetic Therapy".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Biological Therapy [E02.095]
Genetic Therapy [E02.095.301]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Genetic Therapy [E05.393.420.301]

Below are MeSH descriptors whose meaning is more specific than "Genetic Therapy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genetic Therapy" by people in this website by year, and whether "Genetic Therapy" was a major or minor topic of these publications.

Bar chart showing 490 publications over 31 distinct years, with a maximum of 32 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	3	2	5
1996	3	2	5
1997	5	1	6
1998	3	2	5
1999	5	1	6
2000	7	0	7
2001	6	1	7
2002	13	2	15
2003	11	2	13
2004	10	7	17
2005	15	4	19
2006	8	6	14
2007	16	2	18
2008	17	0	17
2009	11	3	14
2010	10	4	14
2011	12	5	17
2012	4	7	11
2013	11	10	21
2014	17	5	22
2015	19	4	23
2016	22	7	29
2017	20	8	28
2018	16	7	23
2019	13	4	17
2020	15	5	20
2021	6	14	20
2022	7	15	22
2023	5	10	15
2024	21	11	32
2025	6	2	8

Below are the most recent publications written about "Genetic Therapy" by people in Profiles.

Roger AL, El Haddad L, Huston ML, Kehoe S, Le D, Khan M, Scarrow E, Gonzalez T, Benkert A, Asokan A, ElMallah MK. GAA replacement improves respiratory muscle, neural, and alveolar pathology in the pompe mouse. Respir Physiol Neurobiol. 2025 Jul; 335:104433.

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Belgrad J, McConnell E, Leonard S, Nolen N, Lauffer MC, Watts JK, Yu T, Yan WX, Aartsma-Rus A. The N=1 Collaborative: advancing customized nucleic acid therapies through collaboration and data sharing. Nucleic Acids Res. 2025 Apr 22; 53(8).

View in: PubMed
Keeler AM, Zhan W, Ram S, Fitzgerald KA, Gao G. The curious case of AAV immunology. Mol Ther. 2025 May 07; 33(5):1946-1965.

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Wang D, Stevens G, Flotte TR. Gene therapy then and now: A look back at changes in the field over the past 25 years. Mol Ther. 2025 May 07; 33(5):1889-1902.

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Wang J, Poskitt LE, Gallagher J, Puffenberger EG, Wynn RM, Shishodia G, Chuang DT, Beever J, Hardin DL, Brigatti KW, Baker WC, Gately R, Bertrand S, Rodrigues A, Benatti HR, Taghian T, Hall E, Prestigiacomo R, Liang J, Chen G, Zhou X, Ren L, Liu N, He R, Su Q, Xie J, Jiang Z, Gruntman A, Gray-Edwards H, Gao G, Strauss KA, Wang D. BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease. Sci Transl Med. 2025 Feb 26; 17(787):eads0539.

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Chaugule S, Constantinou CK, John AA, Micha D, Eekhoff M, Gravallese E, Gao G, Shim JH. Comprehensive Review of Osteogenesis Imperfecta: Current Treatments and Future Innovations. Hum Gene Ther. 2025 Mar; 36(5-6):597-617.

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Walkey CJ, Snow KJ, Bulcha J, Cox AR, Martinez AE, Ljungberg MC, Lanza DG, De Giorgi M, Chuecos MA, Alves-Bezerra M, Suarez CF, Hartig SM, Hilsenbeck SG, Hsu CW, Saville E, Gaitan Y, Duryea J, Hannigan S, Dickinson ME, Mirochnitchenko O, Wang D, Lutz CM, Heaney JD, Gao G, Murray SA, Lagor WR. A comprehensive atlas of AAV tropism in the mouse. Mol Ther. 2025 Mar 05; 33(3):1282-1299.

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Laforet GA. Thrombotic Microangiopathy Associated with Systemic Adeno-Associated Virus Gene Transfer: Review of Reported Cases. Hum Gene Ther. 2025 Feb; 36(3-4):64-76.

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Banou L, Sarrafpour S, Teng CC, Liu J. Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions. Yale J Biol Med. 2024 12; 97(4):491-503.

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Aimo A, Olivotto I, Todiere G, Barison A, Panichella G, Fiuzat M, Linde C, Lakdawala NK, Desai M, Zannad F, Maron MS. Endpoint Selection in Randomized Clinical Trials for Hypertrophic Cardiomyopathy. JACC Heart Fail. 2025 Feb; 13(2):200-212.

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