Adenomatous Polyposis Coli Protein

"Adenomatous Polyposis Coli Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.

Descriptor ID	D025601
MeSH Number(s)	D05.500.117.249 D12.776.220.040 D12.776.476.081.249 D12.776.624.776.010
Concept/Terms	Adenomatous Polyposis Coli Protein Adenomatous Polyposis Coli Protein

Below are MeSH descriptors whose meaning is more general than "Adenomatous Polyposis Coli Protein".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Axin Signaling Complex [D05.500.117]
Adenomatous Polyposis Coli Protein [D05.500.117.249]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cytoskeletal Proteins [D12.776.220]
Adenomatous Polyposis Coli Protein [D12.776.220.040]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Axin Signaling Complex [D12.776.476.081]
Adenomatous Polyposis Coli Protein [D12.776.476.081.249]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Adenomatous Polyposis Coli Protein [D12.776.624.776.010]

Below are MeSH descriptors whose meaning is related to "Adenomatous Polyposis Coli Protein".

Below are MeSH descriptors whose meaning is more specific than "Adenomatous Polyposis Coli Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Adenomatous Polyposis Coli Protein" by people in this website by year, and whether "Adenomatous Polyposis Coli Protein" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 1997 and 2008 and 2010 and 2016 and 2017 and 2019 and 2024 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2008	1	0	1
2010	1	0	1
2016	1	0	1
2017	0	1	1
2019	0	1	1
2024	0	1	1
2025	0	1	1

Below are the most recent publications written about "Adenomatous Polyposis Coli Protein" by people in Profiles.

Gaynor L, Singh H, Tie G, Badarinath K, Madha S, Mancini A, Bhattacharya S, Hoshino M, de Sauvage FJ, Murata K, Jadhav U, Shivdasani RA. Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025 04; 640(8057):231-239.

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Imada S, Khawaled S, Shin H, Meckelmann SW, Whittaker CA, Corr?a RO, Alquati C, Lu Y, Tie G, Pradhan D, Calibasi-Kocal G, Nascentes Melo LM, Allies G, R?sler J, Wittenhofer P, Krystkiewicz J, Schmitz OJ, Roper J, Vinolo MAR, Ricciardiello L, Lien EC, Vander Heiden MG, Shivdasani RA, Cheng CW, Tasdogan A, Yilmaz ?H. Short-term post-fast refeeding enhances intestinal stemness via polyamines. Nature. 2024 09; 633(8031):895-904.

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D'Agostino L, Nie Y, Goswami S, Tong K, Yu S, Bandyopadhyay S, Flores J, Zhang X, Balasubramanian I, Joseph I, Sakamori R, Farrell V, Li Q, Yang CS, Gao B, Ferraris RP, Yehia G, Bonder EM, Goldenring JR, Verzi MP, Zhang L, Ip YT, Gao N. Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling. Cancer Res. 2019 08 15; 79(16):4099-4112.

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Li D, Liu C, Yang C, Wang D, Wu D, Qi Y, Su Q, Gao G, Xu Z, Guo Y. Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS. Neuroscience. 2017 Dec 04; 365:192-205.

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Tekcham DS, Poojary SS, Bhunia S, Barbhuiya MA, Gupta S, Shrivastav BR, Tiwari PK. Epigenetic regulation of APC in the molecular pathogenesis of gallbladder cancer. Indian J Med Res. 2016 May; 143(Supplement):S82-S90.

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Stumpff J, Ghule PN, Shimamura A, Stein JL, Greenblatt M. Spindle microtubule dysfunction and cancer predisposition. J Cell Physiol. 2014 Dec; 229(12):1881-3.

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Swietlicki EA, Bala S, Lu J, Shaker A, Kularatna G, Levin MS, Rubin DC. Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G564-72.

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Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL. Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol. 2010 Jun 28; 189(7):1087-96.

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Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol. 2008 Aug 01; 320(1):161-74.

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Nagamine CM, Sohn JJ, Rickman BH, Rogers AB, Fox JG, Schauer DB. Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse. Infect Immun. 2008 Jun; 76(6):2758-66.

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