"DCC Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
| Descriptor ID |
D000075389
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| MeSH Number(s) |
D12.644.360.075.413 D12.776.476.075.413 D12.776.543.750.003.500 D12.776.624.776.021
|
| Concept/Terms |
DCC Receptor- DCC Receptor
- Receptor, DCC
- DCC Tumor Suppressor Protein
- Deleted in Colorectal Carcinoma Protein
- DCC-Netrin-1 Receptor
- DCC Netrin 1 Receptor
- Receptor, DCC-Netrin-1
|
Below are MeSH descriptors whose meaning is more general than "DCC Receptor".
Below are MeSH descriptors whose meaning is more specific than "DCC Receptor".
This graph shows the total number of publications written about "DCC Receptor" by people in this website by year, and whether "DCC Receptor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "DCC Receptor" by people in Profiles.
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Caldwell TM, Ahn YM, Bulfer SL, Leary CB, Hood MM, Lu WP, Vogeti L, Vogeti S, Kaufman MD, Wise SC, Le Bourdonnec B, Smith BD, Flynn DL. Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT). Bioorg Med Chem Lett. 2022 10 15; 74:128928.
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Virani S, Light E, Peterson LA, Sartor MA, Taylor JM, McHugh JB, Wolf GT, Rozek LS. Stability of methylation markers in head and neck squamous cell carcinoma. Head Neck. 2016 04; 38 Suppl 1:E1325-31.
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Schwarting GA, Raitcheva D, Bless EP, Ackerman SL, Tobet S. Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons. Eur J Neurosci. 2004 Jan; 19(1):11-20.
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Schwarting GA, Kostek C, Bless EP, Ahmad N, Tobet SA. Deleted in colorectal cancer (DCC) regulates the migration of luteinizing hormone-releasing hormone neurons to the basal forebrain. J Neurosci. 2001 Feb 01; 21(3):911-9.