Apoptosis Inducing Factor

"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

Descriptor ID	D051033
MeSH Number(s)	D08.811.682.608.047 D12.644.360.075.311 D12.776.157.687.063 D12.776.331.161 D12.776.476.075.311 D12.776.660.720.063
Concept/Terms	Apoptosis Inducing Factor Apoptosis Inducing Factor Apoptosis-Inducing Factor Mitochondrial Apoptosis-Inducing Factor Apoptosis-Inducing Factor, Mitochondrial Mitochondrial Apoptosis Inducing Factor AIF Apoptosis Regulatory Protein

Below are MeSH descriptors whose meaning is more general than "Apoptosis Inducing Factor".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
NADH, NADPH Oxidoreductases [D08.811.682.608]
Apoptosis Inducing Factor [D08.811.682.608.047]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Apoptosis Inducing Factor [D12.644.360.075.311]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Apoptosis Inducing Factor [D12.776.157.687.063]
Flavoproteins [D12.776.331]
Apoptosis Inducing Factor [D12.776.331.161]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Apoptosis Inducing Factor [D12.776.476.075.311]
Nuclear Proteins [D12.776.660]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Apoptosis Inducing Factor [D12.776.660.720.063]

Below are MeSH descriptors whose meaning is related to "Apoptosis Inducing Factor".

Below are MeSH descriptors whose meaning is more specific than "Apoptosis Inducing Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Apoptosis Inducing Factor" by people in this website by year, and whether "Apoptosis Inducing Factor" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 2004 and 2007 and 2010 and 2014 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2007	1	0	1
2010	0	1	1
2014	1	0	1
2016	1	0	1

Below are the most recent publications written about "Apoptosis Inducing Factor" by people in Profiles.

Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science. 2016 10 07; 354(6308).

View in: PubMed
U KP, Subramanian V, Nicholas AP, Thompson PR, Ferretti P. Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway. Biochim Biophys Acta. 2014 Jun; 1843(6):1162-71.

View in: PubMed
Ferreira IL, Nascimento MV, Ribeiro M, Almeida S, Cardoso SM, Grazina M, Pratas J, Santos MJ, Janu?rio C, Oliveira CR, Rego AC. Mitochondrial-dependent apoptosis in Huntington's disease human cybrids. Exp Neurol. 2010 Apr; 222(2):243-55.

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Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG, Polster BM. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med. 2009 Apr 01; 46(7):939-47.

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Zhu C, Wang X, Deinum J, Huang Z, Gao J, Modjtahedi N, Neagu MR, Nilsson M, Eriksson PS, Hagberg H, Luban J, Kroemer G, Blomgren K. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med. 2007 Aug 06; 204(8):1741-8.

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Kim CH, Han SI, Lee SY, Youk HS, Moon JY, Duong HQ, Park MJ, Joo YM, Park HG, Kim YJ, Yoo MA, Lim SC, Kang HS. Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells. J Cell Physiol. 2007 May; 211(2):371-85.

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Cand? C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C, Luban J, Kroemer RT, Giordanetto F, Garrido C, Penninger JM, Kroemer G. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 2004 Feb 26; 23(8):1514-21.

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