"Werner Syndrome Helicase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
| Descriptor ID |
D000071657
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| MeSH Number(s) |
D08.811.277.040.025.159.249.500 D08.811.277.352.335.375.875 D08.811.277.352.365.290.500 D08.811.399.340.249.500 D12.776.157.687.750 D12.776.660.720.750
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| Concept/Terms |
Werner Syndrome Helicase- Werner Syndrome Helicase
- Helicase, Werner Syndrome
- Werner Syndrome ATP-Dependent Helicase
- Werner Syndrome ATP Dependent Helicase
- RECQL2 Protein
- Werner Syndrome RecQ-Like Helicase
- Werner Syndrome RecQ Like Helicase
- RECQ3 Protein
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Below are MeSH descriptors whose meaning is more general than "Werner Syndrome Helicase".
Below are MeSH descriptors whose meaning is more specific than "Werner Syndrome Helicase".
This graph shows the total number of publications written about "Werner Syndrome Helicase" by people in this website by year, and whether "Werner Syndrome Helicase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Werner Syndrome Helicase" by people in Profiles.
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Sharma A, Awasthi S, Harrod CK, Matlock EF, Khan S, Xu L, Chan S, Yang H, Thammavaram CK, Rasor RA, Burns DK, Skiest DJ, Van Lint C, Girard AM, McGee M, Monnat RJ, Harrod R. The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication. J Biol Chem. 2007 Apr 20; 282(16):12048-57.
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Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL, West MD, Wilmoth JR, Wright WE. The aging factor in health and disease: the promise of basic research on aging. Aging Clin Exp Res. 2004 Apr; 16(2):104-11; discussion 111-2.