CCCTC-Binding Factor

"CCCTC-Binding Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.

Descriptor ID	D000076246
MeSH Number(s)	D12.776.157.687.157 D12.776.260.120 D12.776.660.235.050 D12.776.660.720.157 D12.776.664.235.050 D12.776.930.780.563
Concept/Terms	CCCTC-Binding Factor CCCTC-Binding Factor CCCTC Binding Factor DNA-Binding Protein CTCF CTCF, DNA-Binding Protein DNA Binding Protein CTCF CTCF Protein

Below are MeSH descriptors whose meaning is more general than "CCCTC-Binding Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
CCCTC-Binding Factor [D12.776.157.687.157]
DNA-Binding Proteins [D12.776.260]
CCCTC-Binding Factor [D12.776.260.120]
Nuclear Proteins [D12.776.660]
Chromosomal Proteins, Non-Histone [D12.776.660.235]
CCCTC-Binding Factor [D12.776.660.235.050]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
CCCTC-Binding Factor [D12.776.660.720.157]
Nucleoproteins [D12.776.664]
Chromosomal Proteins, Non-Histone [D12.776.664.235]
CCCTC-Binding Factor [D12.776.664.235.050]
Transcription Factors [D12.776.930]
Repressor Proteins [D12.776.930.780]
CCCTC-Binding Factor [D12.776.930.780.563]

Below are MeSH descriptors whose meaning is related to "CCCTC-Binding Factor".

Below are MeSH descriptors whose meaning is more specific than "CCCTC-Binding Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CCCTC-Binding Factor" by people in this website by year, and whether "CCCTC-Binding Factor" was a major or minor topic of these publications.

Bar chart showing 28 publications over 13 distinct years, with a maximum of 5 publications in 2016 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2009	0	1	1
2012	0	2	2
2013	0	2	2
2014	0	1	1
2015	0	3	3
2016	0	5	5
2017	1	4	5
2019	2	1	3
2020	0	2	2
2021	0	1	1
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "CCCTC-Binding Factor" by people in Profiles.

Rahman S, Bloye G, Farah N, Demeulemeester J, Costa JR, O'Connor D, Pocock R, Rapoz-D'Silva T, Turna A, Wang L, Lee S, Fielding AK, Roels J, Jaksik R, Dawidowska M, Van Vlierberghe P, Hadjur S, Hughes JR, Davies JOJ, Gutierrez A, Kelliher MA, Van Loo P, Dawson MA, Mansour MR. Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia. Blood. 2024 Nov 28; 144(22):2319-2326.

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Valton AL, Venev SV, Mair B, Khokhar ES, Tong AHY, Usaj M, Chan K, Pai AA, Moffat J, Dekker J. A cohesin traffic pattern genetically linked to gene regulation. Nat Struct Mol Biol. 2022 12; 29(12):1239-1251.

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Cha HJ, Uyan ?, Kai Y, Liu T, Zhu Q, Tothova Z, Botten GA, Xu J, Yuan GC, Dekker J, Orkin SH. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Nat Commun. 2021 10 29; 12(1):6241.

View in: PubMed
Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Rando OJ, Tjian R, Darzacq X. Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding. Mol Cell. 2020 05 07; 78(3):539-553.e8.

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Krietenstein N, Abraham S, Venev SV, Abdennur N, Gibcus J, Hsieh TS, Parsi KM, Yang L, Maehr R, Mirny LA, Dekker J, Rando OJ. Ultrastructural Details of Mammalian Chromosome Architecture. Mol Cell. 2020 05 07; 78(3):554-565.e7.

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Tarjan DR, Flavahan WA, Bernstein BE. Epigenome editing strategies for the functional annotation of CTCF insulators. Nat Commun. 2019 09 18; 10(1):4258.

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Mirny LA, Imakaev M, Abdennur N. Two major mechanisms of chromosome organization. Curr Opin Cell Biol. 2019 06; 58:142-152.

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Oomen ME, Hansen AS, Liu Y, Darzacq X, Dekker J. CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning. Genome Res. 2019 02; 29(2):236-249.

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Tai PWL, Wu H, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation. PLoS One. 2017; 12(11):e0188056.

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Rodr?guez-Carballo E, Lopez-Delisle L, Zhan Y, Fabre PJ, Beccari L, El-Idrissi I, Huynh THN, Ozadam H, Dekker J, Duboule D. The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes. Genes Dev. 2017 11 15; 31(22):2264-2281.

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