Transcription Factor AP-2

"Transcription Factor AP-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

Descriptor ID	D050656
MeSH Number(s)	D12.776.260.760 D12.776.930.907
Concept/Terms	Transcription Factor AP-2 Transcription Factor AP-2 AP-2, Transcription Factor Transcription Factor AP 2 Transcription Factor AP2 Enhancer-Binding Protein AP-2 AP-2, Enhancer-Binding Protein Enhancer Binding Protein AP 2 Activator Protein AP-2 AP-2, Activator Protein Activator Protein AP 2 AP-2 Enhancer Binding Protein AP 2 Enhancer Binding Protein Transcription Factor AP-2 epsilon Protein Transcription Factor AP-2 epsilon Protein Transcription Factor AP 2 epsilon Protein Transcription Factor AP-2epsilon AP-2epsilon, Transcription Factor Transcription Factor AP 2epsilon AP-2 epsilon Protein Transcription Factor AP-2 beta Protein Transcription Factor AP-2 beta Protein Transcription Factor AP 2 beta Protein TFAP2B Protein Transcription Factor AP-2beta AP-2beta, Transcription Factor Transcription Factor AP 2beta AP-2 beta Protein AP 2 beta Protein Transcription Factor AP-2 delta Protein Transcription Factor AP-2 delta Protein Transcription Factor AP 2 delta Protein Transcription Factor Ap-2delta Ap-2delta, Transcription Factor Transcription Factor Ap 2delta AP-2delta Protein AP 2delta Protein Transcription Factor AP-2 gamma Protein Transcription Factor AP-2 gamma Protein Transcription Factor AP 2 gamma Protein Transcription Factor AP-2gamma AP-2gamma, Transcription Factor Transcription Factor AP 2gamma AP-2 gamma Protein AP 2 gamma Protein Transcription Factor AP-2 alpha Protein Transcription Factor AP-2 alpha Protein Transcription Factor AP 2 alpha Protein AP-2 alpha Protein AP 2 alpha Protein TFAP2alpha Protein Transcription Factor AP-2alpha AP-2alpha, Transcription Factor Transcription Factor AP 2alpha

Below are MeSH descriptors whose meaning is more general than "Transcription Factor AP-2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Transcription Factor AP-2 [D12.776.260.760]
Transcription Factors [D12.776.930]
Transcription Factor AP-2 [D12.776.930.907]

Below are MeSH descriptors whose meaning is related to "Transcription Factor AP-2".

Below are MeSH descriptors whose meaning is more specific than "Transcription Factor AP-2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transcription Factor AP-2" by people in this website by year, and whether "Transcription Factor AP-2" was a major or minor topic of these publications.

Bar chart showing 11 publications over 5 distinct years, with a maximum of 4 publications in 2005

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2000	1	1
2002	2	2
2004	3	3
2005	4	4
2010	1	1

Below are the most recent publications written about "Transcription Factor AP-2" by people in Profiles.

Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Masuzaki H, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Nakamura Y, Kamatani N. Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. J Hum Genet. 2010 Nov; 55(11):738-42.

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Afzal F, Pratap J, Ito K, Ito Y, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Javed A. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol. 2005 Jul; 204(1):63-72.

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Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr; 203(1):133-43.

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Galindo M, Pratap J, Young DW, Hovhannisyan H, Im HJ, Choi JY, Lian JB, Stein JL, Stein GS, van Wijnen AJ. The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem. 2005 May 27; 280(21):20274-85.

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Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB. SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 2005 Mar 01; 94(4):720-30.

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Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, van Wijnen A, Lian JB, Stein GS, Stein JL, Montecino M. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol. 2004 Oct; 24(20):8847-61.

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Castilla LH, Perrat P, Martinez NJ, Landrette SF, Keys R, Oikemus S, Flanegan J, Heilman S, Garrett L, Dutra A, Anderson S, Pihan GA, Wolff L, Liu PP. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4924-9.

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Zaidi SK, Sullivan AJ, Medina R, Ito Y, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J. 2004 Feb 25; 23(4):790-9.

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Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls GH, Stein GS, Liu PP. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002 Dec; 32(4):639-44.

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Miller J, Horner A, Stacy T, Lowrey C, Lian JB, Stein G, Nuckolls GH, Speck NA. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Nat Genet. 2002 Dec; 32(4):645-9.

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