"Core Binding Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
| Descriptor ID |
D050660
|
| MeSH Number(s) |
D12.776.930.155
|
| Concept/Terms |
Core Binding Factors- Core Binding Factors
- Binding Factors, Core
- Factors, Core Binding
- PEBP2 Transcription Factor
- Transcription Factor, PEBP2
- Polyomavirus Enhancer Binding Protein 2
- Core-Binding Factor
- Core Binding Factor
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factors".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factors".
This graph shows the total number of publications written about "Core Binding Factors" by people in this website by year, and whether "Core Binding Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Core Binding Factors" by people in Profiles.
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Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls GH, Stein GS, Liu PP. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002 Dec; 32(4):639-44.
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Guti?rrez J, Sierra J, Medina R, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M. Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site. Biochemistry. 2000 Nov 07; 39(44):13565-74.