Core Binding Factor beta Subunit

"Core Binding Factor beta Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.

Descriptor ID	D050658
MeSH Number(s)	D12.776.930.155.400
Concept/Terms	Core Binding Factor beta Subunit Core Binding Factor beta Subunit Core Binding Factor beta Polyomavirus Enhancer Binding Protein 2, beta Subunit CBFB Protein Core Binding Factor beta Protein

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor beta Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor beta Subunit [D12.776.930.155.400]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor beta Subunit".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor beta Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor beta Subunit" by people in this website by year, and whether "Core Binding Factor beta Subunit" was a major or minor topic of these publications.

Bar chart showing 19 publications over 15 distinct years, with a maximum of 2 publications in 2006 and 2014 and 2017 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	1	1
2004	0	1	1
2006	1	1	2
2009	1	0	1
2010	1	0	1
2012	1	0	1
2013	0	1	1
2014	2	0	2
2015	1	0	1
2016	1	0	1
2017	1	1	2
2021	1	1	2
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Core Binding Factor beta Subunit" by people in Profiles.

Hegde M, Ahmad MH, Mulet Lazaro R, Sugita M, Li R, Hu K, Gebhard C, Guzman ML, Bushweller JH, Zhu LJ, Brehm M, Wolfe SA, Delwel R, Castilla LH. The co-receptor Neuropilin-1 enhances proliferation in inv(16) acute myeloid leukemia via VEGF signaling. Leukemia. 2025 Feb; 39(2):360-370.

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Che X, Jin X, Park NR, Kim HJ, Kyung HS, Kim HJ, Lian JB, Stein JL, Stein GS, Choi JY. Cbf? Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-? Signaling. Cells. 2023 03 31; 12(7).

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van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB. Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter. Blood. 2021 10 14; 138(15):1345-1358.

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Che X, Park NR, Jin X, Jung YK, Han MS, Park CY, Chun JS, Kim SG, Jin J, Kim HJ, Lian JB, Stein JL, Stein GS, Choi JY. Hypoxia-inducible factor 2a is a novel inhibitor of chondrocyte maturation. J Cell Physiol. 2021 10; 236(10):6963-6973.

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Choi A, Illendula A, Pulikkan JA, Roderick JE, Tesell J, Yu J, Hermance N, Zhu LJ, Castilla LH, Bushweller JH, Kelliher MA. RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia. Blood. 2017 10 12; 130(15):1722-1733.

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Castilla LH, Bushweller JH. Molecular Basis and Targeted Inhibition of CBF?-SMMHC Acute Myeloid Leukemia. Adv Exp Med Biol. 2017; 962:229-244.

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Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH. Small Molecule Inhibitor of CBF?-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun; 8:117-131.

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Lim KE, Park NR, Che X, Han MS, Jeong JH, Kim SY, Park CY, Akiyama H, Kim JE, Ryoo HM, Stein JL, Lian JB, Stein GS, Choi JY. Core binding factor ? of osteoblasts maintains cortical bone mass via stabilization of Runx2 in mice. J Bone Miner Res. 2015 Apr; 30(4):715-22.

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Lopez-Camacho C, van Wijnen AJ, Lian JB, Stein JL, Stein GS. CBF? and the leukemogenic fusion protein CBF?-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genes. J Cell Biochem. 2014 Dec; 115(12):2155-64.

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Lopez-Camacho C, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Core binding factor ? (CBF?) is retained in the midbody during cytokinesis. J Cell Physiol. 2014 Oct; 229(10):1466-74.

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