Protein-Arginine Deiminases

"Protein-Arginine Deiminases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of ENZYMES that, in the presence of calcium ion, converts ARGININE to CITRULLINE in proteins.

Descriptor ID	D000076342
MeSH Number(s)	D08.811.277.721
Concept/Terms	Protein-Arginine Deiminases Protein-Arginine Deiminases Deiminases, Protein-Arginine Protein Arginine Deiminases Protein-L-Arginine Iminohydrolase Iminohydrolase, Protein-L-Arginine Protein L Arginine Iminohydrolase Protein-Arginine Deiminase Deiminase, Protein-Arginine Protein Arginine Deiminase Peptidylarginine Deiminase Deiminase, Peptidylarginine Peptidylarginine Deiminases Deiminases, Peptidylarginine Protein-L-Arginine Iminohydrolases Iminohydrolases, Protein-L-Arginine Protein L Arginine Iminohydrolases

Below are MeSH descriptors whose meaning is more general than "Protein-Arginine Deiminases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Protein-Arginine Deiminases [D08.811.277.721]

Below are MeSH descriptors whose meaning is related to "Protein-Arginine Deiminases".

Below are MeSH descriptors whose meaning is more specific than "Protein-Arginine Deiminases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein-Arginine Deiminases" by people in this website by year, and whether "Protein-Arginine Deiminases" was a major or minor topic of these publications.

Bar chart showing 77 publications over 19 distinct years, with a maximum of 8 publications in 2014 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2006	0	4	4
2007	0	2	2
2008	0	2	2
2009	0	1	1
2010	0	4	4
2011	0	7	7
2012	0	4	4
2013	0	3	3
2014	0	8	8
2015	0	6	6
2016	4	3	7
2017	1	3	4
2018	5	3	8
2019	4	1	5
2020	1	1	2
2021	1	4	5
2023	0	3	3
2024	0	1	1

Below are the most recent publications written about "Protein-Arginine Deiminases" by people in Profiles.

Yusuf IO, Parsi S, Ostrow LW, Brown RH, Thompson PR, Xu Z. PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS. Neurobiol Dis. 2024 Mar; 192:106414.

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Zhu YP, Speir M, Tan Z, Lee JC, Nowell CJ, Chen AA, Amatullah H, Salinger AJ, Huang CJ, Wu G, Peng W, Askari K, Griffis E, Ghassemian M, Santini J, Gerlic M, Kiosses WB, Catz SD, Hoffman HM, Greco KF, Weller E, Thompson PR, Wong LP, Sadreyev R, Jeffrey KL, Croker BA. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. Sci Adv. 2023 Dec 22; 9(51):eadj1397.

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Geary B, Sun B, Tilvawala RR, Barasa L, Tsoyi K, Rosas IO, Thompson PR, Ho IC. Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA. Front Immunol. 2023; 14:1290585.

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Barasa L, Thompson PR. Protein citrullination: inhibition, identification and insertion. Philos Trans R Soc Lond B Biol Sci. 2023 11 20; 378(1890):20220240.

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Maurais AJ, Salinger AJ, Tobin M, Shaffer SA, Weerapana E, Thompson PR. A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination. Biochemistry. 2021 09 28; 60(38):2902-2914.

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Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 08; 102:70-84.

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Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszl?n G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 06 23; 12(1):3910.

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Funabashi K, Sawata M, Nagai A, Akimoto M, Mashimo R, Takahara H, Kizawa K, Thompson PR, Ite K, Kitanishi K, Unno M. Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. Arch Biochem Biophys. 2021 Sep 15; 708:108911.

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Mondal S, Thompson PR. Chemical biology of protein citrullination by the protein A arginine deiminases. Curr Opin Chem Biol. 2021 08; 63:19-27.

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Sodr? FMC, Bissenova S, Bruggeman Y, Tilvawala R, Cook DP, Berthault C, Mondal S, Callebaut A, You S, Scharfmann R, Mallone R, Thompson PR, Mathieu C, Buitinga M, Overbergh L. Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice. Diabetes. 2021 02; 70(2):516-528.

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