Enzyme Inhibitors

"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Descriptor ID	D004791
MeSH Number(s)	D27.505.519.389
Concept/Terms	Enzyme Inhibitors Enzyme Inhibitors Inhibitors, Enzyme

Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]

Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.

Bar chart showing 310 publications over 31 distinct years, with a maximum of 19 publications in 2007 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	3	4
1997	3	6	9
1998	4	5	9
1999	1	9	10
2000	3	6	9
2001	1	8	9
2002	4	11	15
2003	4	9	13
2004	1	17	18
2005	3	11	14
2006	5	10	15
2007	5	14	19
2008	3	9	12
2009	5	13	18
2010	7	12	19
2011	7	4	11
2012	2	5	7
2013	9	7	16
2014	5	10	15
2015	6	6	12
2016	6	2	8
2017	7	2	9
2018	2	7	9
2019	5	2	7
2020	2	5	7
2021	4	1	5
2022	0	2	2
2023	0	1	1
2024	2	2	4
2025	3	0	3
2026	1	0	1

Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.

Rossetti T, Han L, Barasa L, Tran T, Hwang S, O'Reilly M, Xu Z, Thompson PR. Development of Next-Generation Fluoroacetamidine-Containing Activity-Based Probes for the Selective Labeling of the Protein Arginine Deiminases (PADs). ACS Chem Biol. 2026 Jul 17; 21(7):1749-1764.

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Hedger AK, Myint W, Lee JM, Suchenski Loustaunau D, Balachandran V, Shaqra AM, Kurt Yilmaz N, Watts JK, Matsuo H, Schiffer CA. Next generation?APOBEC3 inhibitors: optimally designed for potency and nuclease stability. Nucleic Acids Res. 2025 Mar 20; 53(6).

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Wang Y, Cheng J, McClements DJ, Chen J, Ma D. A novel synergistic inhibition mechanism of pancreatic lipase by 2-mercaptobenzothiazole and stearic acid migrants from dairy contact rubbers. Food Chem. 2025 Jul 01; 479:143816.

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Andrews J, Paganoni S, Macklin EA, Chibnik LB, Quintana M, Saville BR, Detry MA, Vestrucci M, Marion J, McGlothlin A, Young E, Chase M, Pothier L, Harkey B, Yu H, Sherman A, Shefner J, Hall M, Kittle G, Connolly MR, Berry JD, D'Agostino D, Tustison E, Giacomelli E, Scirocco E, Alameda G, Locatelli E, Ho D, Quick A, Heitzman D, Ajroud-Driss S, Appel SH, Shroff S, Katz J, Felice K, Maragakis NJ, Simmons Z, Goutman SA, Olney N, Miller T, Fernandes JA, Ilieva H, Jawdat O, Weiss MD, Foster L, Vu T, Ladha S, Owegi MA, Newman DS, Arcila-Londono X, Jackson CE, Swenson A, Heiman-Patterson T, Caress J, Fee D, Peltier A, Lewis R, Rosenfeld J, Walk D, Johnson K, Elliott M, Kasarskis EJ, Rutkove S, McIlduff CE, Bedlack R, Elman L, Goyal NA, Rezania K, Twydell P, Benatar M, Glass J, Cohen JA, Jones V, Zilliox L, Wymer JP, Beydoun SR, Shah J, Pattee GL, Martinez-Thompson J, Nayar S, Granit V, Donohue M, Grossman K, Campbell DJ, Qureshi IA, Cudkowicz ME, Babu S. Verdiperstat in Amyotrophic Lateral Sclerosis: Results From the Randomized HEALEY ALS Platform Trial. JAMA Neurol. 2025 04; 82(4):333-343.

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Guan W, Cheng J, McClements DJ, Tu Z, Chen J, Ma D. Impact of 2,4-di-tert-butylphenol on pancreatic lipase activity in emulsions: Multispectral, molecular docking, and in vitro digestion analysis. Food Chem. 2025 Apr 01; 470:142730.

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Norman M, Yamartino K, Gerstein R, Shallis R, Mendez L, Podoltsev N, Stahl M, Eighmy W, Zeidan AM. A review of the isocitrate dehydrogenase inhibitors in management of adult patients with AML and MDS. Expert Rev Hematol. 2024 11; 17(11):755-767.

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Lim HW, Kim HJ, Jeon CY, Lee Y, Kim M, Kim J, Kim SR, Lee S, Lim DC, Park HD, Park BC, Shin DW. Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells. Int J Mol Sci. 2024 Jul 08; 25(13).

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Mpakali A, Barla I, Lu L, Ramesh KM, Thomaidis N, Stern LJ, Giastas P, Stratikos E. Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J Mol Biol. 2024 03 15; 436(6):168449.

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Mohammad I, Liebmann KL, Miller SC. Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases. Chem Commun (Camb). 2023 Jul 06; 59(55):8552-8555.

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Lin Q, Qiu C, Li X, Sang S, McClements DJ, Chen L, Long J, Jiao A, Tian Y, Jin Z. The inhibitory mechanism of amylase inhibitors and research progress in nanoparticle-based inhibitors. Crit Rev Food Sci Nutr. 2023 Nov; 63(33):12126-12135.

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