Folic Acid Antagonists

"Folic Acid Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)

Descriptor ID	D005493
MeSH Number(s)	D27.505.519.389.350
Concept/Terms	Folic Acid Antagonists Folic Acid Antagonists Acid Antagonists, Folic Antagonists, Folic Acid Dihydrofolate Reductase Inhibitors Inhibitors, Dihydrofolate Reductase Reductase Inhibitors, Dihydrofolate Antifolates Folic Acid Metabolism Inhibitors Folic Acid Metabolism Inhibitors

Below are MeSH descriptors whose meaning is more general than "Folic Acid Antagonists".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Folic Acid Antagonists [D27.505.519.389.350]

Below are MeSH descriptors whose meaning is related to "Folic Acid Antagonists".

Below are MeSH descriptors whose meaning is more specific than "Folic Acid Antagonists".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Folic Acid Antagonists" by people in this website by year, and whether "Folic Acid Antagonists" was a major or minor topic of these publications.

Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 2004 and 2007 and 2021 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2007	0	1	1
2021	1	0	1
2022	1	0	1

Below are the most recent publications written about "Folic Acid Antagonists" by people in Profiles.

Kreutzfeld O, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA, Rosenthal PJ. Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates. J Infect Dis. 2022 02 15; 225(4):696-704.

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Asua V, Conrad MD, Aydemir O, Duvalsaint M, Legac J, Duarte E, Tumwebaze P, Chin DM, Cooper RA, Yeka A, Kamya MR, Dorsey G, Nsobya SL, Bailey J, Rosenthal PJ. Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda. J Infect Dis. 2021 03 29; 223(6):985-994.

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Han LY, Ma XH, Lin HH, Jia J, Zhu F, Xue Y, Li ZR, Cao ZW, Ji ZL, Chen YZ. A support vector machines approach for virtual screening of active compounds of single and multiple mechanisms from large libraries at an improved hit-rate and enrichment factor. J Mol Graph Model. 2008 Jun; 26(8):1276-86.

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Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul; 53(1):275-82.

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Lucchesi PA, Romano FD, Scheid CR, Yamaguchi H, Honeyman TW. Interaction of agonists and selective antagonists with gastric smooth muscle muscarinic receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb; 339(1-2):145-51.

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Browman GP, Gorka C, Mehta C, Lazarus H, Abelson HT. Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate. Biochem Pharmacol. 1980 Aug 15; 29(16):2241-5.

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Rosowsky A, Lazarus H, Yuan GC, Beltz WR, Mangini L, Abelson HT, Modest EJ, Frei E. Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts. Biochem Pharmacol. 1980 Feb 15; 29(4):648-52.

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Johnson LF, Fuhrman CL, Abelson HT. Resistance of resting 3T6 mouse fibroblasts to methotrexate cytotoxicity. Cancer Res. 1978 Aug; 38(8):2408-12.

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