Lipoxygenase Inhibitors

"Lipoxygenase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.

Descriptor ID	D016859
MeSH Number(s)	D27.505.519.389.480
Concept/Terms	Lipoxygenase Inhibitors Lipoxygenase Inhibitors Inhibitors, Lipoxygenase Arachidonate 15-Lipoxygenase Inhibitors Arachidonate 15-Lipoxygenase Inhibitors 15-Lipoxygenase Inhibitors, Arachidonate Arachidonate 15 Lipoxygenase Inhibitors Inhibitors, Arachidonate 15-Lipoxygenase 15-Lipoxygenase Inhibitors 15 Lipoxygenase Inhibitors Inhibitors, 15-Lipoxygenase Arachidonate 5-Lipoxygenase Inhibitors Arachidonate 5-Lipoxygenase Inhibitors 5-Lipoxygenase Inhibitors, Arachidonate Arachidonate 5 Lipoxygenase Inhibitors Inhibitors, Arachidonate 5-Lipoxygenase 5-Lipoxygenase Inhibitors 5 Lipoxygenase Inhibitors Inhibitors, 5-Lipoxygenase Arachidonate 12-Lipoxygenase Inhibitors Arachidonate 12-Lipoxygenase Inhibitors 12-Lipoxygenase Inhibitors, Arachidonate Arachidonate 12 Lipoxygenase Inhibitors Inhibitors, Arachidonate 12-Lipoxygenase 12-Lipoxygenase Inhibitors 12 Lipoxygenase Inhibitors Inhibitors, 12-Lipoxygenase

Below are MeSH descriptors whose meaning is more general than "Lipoxygenase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Lipoxygenase Inhibitors [D27.505.519.389.480]

Below are MeSH descriptors whose meaning is related to "Lipoxygenase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Lipoxygenase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lipoxygenase Inhibitors" by people in this website by year, and whether "Lipoxygenase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 4 publications over 3 distinct years, with a maximum of 2 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	1	1
2010	0	2	2
2011	1	0	1

Below are the most recent publications written about "Lipoxygenase Inhibitors" by people in Profiles.

Woodruff PG, Albert RK, Bailey WC, Casaburi R, Connett JE, Cooper JA, Criner GJ, Curtis JL, Dransfield MT, Han MK, Harnden SM, Kim V, Marchetti N, Martinez FJ, McEvoy CE, Niewoehner DE, Reilly JJ, Rice K, Scanlon PD, Scharf SM, Sciurba FC, Washko GR, Lazarus SC. Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. COPD. 2011 Feb; 8(1):21-9.

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Divangahi M, Desjardins D, Nunes-Alves C, Remold HG, Behar SM. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol. 2010 Aug; 11(8):751-8.

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Chen Y, Peng C, Sullivan C, Li D, Li S. Novel therapeutic agents against cancer stem cells of chronic myeloid leukemia. Anticancer Agents Med Chem. 2010 Feb; 10(2):111-5.

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McCormick DL, Phillips JM, Horn TL, Johnson WD, Steele VE, Lubet RA. Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. Cancer Prev Res (Phila). 2010 Jan; 3(1):73-81.

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Chen Y, Li D, Li S. The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia. Cell Cycle. 2009 Nov 01; 8(21):3488-92.

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Carraway RE, Hassan S, Cochrane DE. Regulation of neurotensin receptor function by the arachidonic acid-lipoxygenase pathway in prostate cancer PC3 cells. Prostaglandins Leukot Essent Fatty Acids. 2006 Feb; 74(2):93-107.

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Wang H, Li J, Follett PL, Zhang Y, Cotanche DA, Jensen FE, Volpe JJ, Rosenberg PA. 12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur J Neurosci. 2004 Oct; 20(8):2049-58.

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Smith HL, Rajan TV. Inhibitors of the lipoxygenase pathway block development of Brugia malayi L3 in vitro. J Parasitol. 2001 Apr; 87(2):242-9.

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Drazen JM, Lilly CM, Sperling R, Rubin P, Israel E. Role of cysteinyl leukotrienes in spontaneous asthmatic responses. Adv Prostaglandin Thromboxane Leukot Res. 1994; 22:251-62.

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Israel E, Fischer AR, Rosenberg MA, Lilly CM, Callery JC, Shapiro J, Cohn J, Rubin P, Drazen JM. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1447-51.

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