X Chromosome Inactivation

"X Chromosome Inactivation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A dosage compensation process occurring at an early embryonic stage in mammalian development whereby, at random, one X CHROMOSOME of the pair is repressed in the somatic cells of females.

Descriptor ID	D049951
MeSH Number(s)	G05.308.203.249.970
Concept/Terms	X Chromosome Inactivation X Chromosome Inactivation Chromosome Inactivation, X Inactivation, X Chromosome Lyonization X-Inactivation X Inactivation Inactivation, X X Inactivations Lyon Hypothesis Lyon Hypothesis Hypothesis, Lyon

Below are MeSH descriptors whose meaning is more general than "X Chromosome Inactivation".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epigenesis, Genetic [G05.308.203]
Dosage Compensation, Genetic [G05.308.203.249]
X Chromosome Inactivation [G05.308.203.249.970]

Below are MeSH descriptors whose meaning is related to "X Chromosome Inactivation".

Below are MeSH descriptors whose meaning is more specific than "X Chromosome Inactivation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "X Chromosome Inactivation" by people in this website by year, and whether "X Chromosome Inactivation" was a major or minor topic of these publications.

Bar chart showing 34 publications over 17 distinct years, with a maximum of 5 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2006	1	1	2
2007	2	2	4
2008	1	0	1
2010	1	0	1
2011	1	0	1
2012	2	1	3
2013	0	2	2
2014	3	0	3
2015	1	0	1
2016	2	3	5
2017	1	0	1
2019	1	0	1
2020	2	1	3
2023	2	0	2
2024	2	0	2
2025	1	0	1

Below are the most recent publications written about "X Chromosome Inactivation" by people in Profiles.

Lou S, DJiake Tihagam R, Wasko UN, Equbal Z, Venkatesan S, Braczyk K, Przanowski P, Il Koo B, Saltani I, Singh AT, Likhite S, Powers S, Souza GMPR, Maxwell RA, Yu J, Zhu LJ, Beenhakker M, Abbott SBG, Lu Z, Green MR, Meyer KC, Tushir-Singh J, Bhatnagar S. Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype. Nat Commun. 2025 Jul 04; 16(1):6169.

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Wang F, Mehta P, Bach I. How does the Xist activator Rlim/Rnf12 regulate Xist expression? Biochem Soc Trans. 2024 06 26; 52(3):1099-1107.

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Gupta K, Czerminski JT, Lawrence JB. Trisomy silencing by XIST: translational prospects and challenges. Hum Genet. 2024 Jul; 143(7):843-855.

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Wang F, Chander A, Yoon Y, Welton JM, Wallingford MC, Espejo-Serrano C, Bustos F, Findlay GM, Mager J, Bach I. Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice. Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52):e2313200120.

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Valledor M, Byron M, Dumas B, Carone DM, Hall LL, Lawrence JB. Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing. Cell Rep. 2023 07 25; 42(7):112686.

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Dossin F, Pinheiro I, Zylicz JJ, Roensch J, Collombet S, Le Saux A, Chelmicki T, Attia M, Kapoor V, Zhan Y, Dingli F, Loew D, Mercher T, Dekker J, Heard E. SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature. 2020 02; 578(7795):455-460.

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Morcillo P, Qin Y, Pe?a G, Mosenthal AC, Livingston DH, Spolarics Z. Directional X Chromosome Skewing of White Blood Cells from Subjects with Heterozygous Mosaicism for the Variant IRAK1 Haplotype. Inflammation. 2020 Feb; 43(1):370-381.

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Czerminski JT, Lawrence JB. Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation. Dev Cell. 2020 02 10; 52(3):294-308.e3.

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Gdula MR, Nesterova TB, Pintacuda G, Godwin J, Zhan Y, Ozadam H, McClellan M, Moralli D, Krueger F, Green CM, Reik W, Kriaucionis S, Heard E, Dekker J, Brockdorff N. The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome. Nat Commun. 2019 01 03; 10(1):30.

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Wang F, McCannell KN, Bo?kovic A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I. Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep. 2017 12 26; 21(13):3691-3699.

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