X Chromosome Inactivation
"X Chromosome Inactivation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dosage compensation process occurring at an early embryonic stage in mammalian development whereby, at random, one X CHROMOSOME of the pair is repressed in the somatic cells of females.
| Descriptor ID |
D049951
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| MeSH Number(s) |
G05.308.203.249.970
|
| Concept/Terms |
X Chromosome Inactivation- X Chromosome Inactivation
- Chromosome Inactivation, X
- Inactivation, X Chromosome
- Lyonization
- X-Inactivation
- X Inactivation
- Inactivation, X
- X Inactivations
|
Below are MeSH descriptors whose meaning is more general than "X Chromosome Inactivation".
Below are MeSH descriptors whose meaning is more specific than "X Chromosome Inactivation".
This graph shows the total number of publications written about "X Chromosome Inactivation" by people in this website by year, and whether "X Chromosome Inactivation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 2 | 2 | 4 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2013 | 0 | 2 | 2 |
| 2014 | 3 | 0 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 3 | 5 |
| 2017 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 1 | 3 |
| 2023 | 2 | 0 | 2 |
| 2024 | 3 | 0 | 3 |
| 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "X Chromosome Inactivation" by people in Profiles.
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Welton JM, Tremblay KD, Mager J. Loss of CMTR1 leads to gastrulation failure and early embryonic lethality. Dev Biol. 2025 12; 528:1-12.
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Lou S, DJiake Tihagam R, Wasko UN, Equbal Z, Venkatesan S, Braczyk K, Przanowski P, Il Koo B, Saltani I, Singh AT, Likhite S, Powers S, Souza GMPR, Maxwell RA, Yu J, Zhu LJ, Beenhakker M, Abbott SBG, Lu Z, Green MR, Meyer KC, Tushir-Singh J, Bhatnagar S. Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype. Nat Commun. 2025 Jul 04; 16(1):6169.
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Forsyth KS, Toothacre NE, Jiwrajka N, Driscoll AM, Shallberg LA, Cunningham-Rundles C, Barmettler S, Farmer J, Verbsky J, Routes J, Beiting DP, Romberg N, May MJ, Anguera MC. Maintenance of X chromosome inactivation after T cell activation requires NF-?B signaling. Sci Immunol. 2024 10 04; 9(100):eado0398.
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Wang F, Mehta P, Bach I. How does the Xist activator Rlim/Rnf12 regulate Xist expression? Biochem Soc Trans. 2024 06 26; 52(3):1099-1107.
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Gupta K, Czerminski JT, Lawrence JB. Trisomy silencing by XIST: translational prospects and challenges. Hum Genet. 2024 Jul; 143(7):843-855.
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Wang F, Chander A, Yoon Y, Welton JM, Wallingford MC, Espejo-Serrano C, Bustos F, Findlay GM, Mager J, Bach I. Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice. Proc Natl Acad Sci U S A. 2023 12 26; 120(52):e2313200120.
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Valledor M, Byron M, Dumas B, Carone DM, Hall LL, Lawrence JB. Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing. Cell Rep. 2023 07 25; 42(7):112686.
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Dossin F, Pinheiro I, ?ylicz JJ, Roensch J, Collombet S, Le Saux A, Chelmicki T, Attia M, Kapoor V, Zhan Y, Dingli F, Loew D, Mercher T, Dekker J, Heard E. SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature. 2020 02; 578(7795):455-460.
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Morcillo P, Qin Y, Peña G, Mosenthal AC, Livingston DH, Spolarics Z. Directional X Chromosome Skewing of White Blood Cells from Subjects with Heterozygous Mosaicism for the Variant IRAK1 Haplotype. Inflammation. 2020 Feb; 43(1):370-381.
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Czermi?ski JT, Lawrence JB. Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation. Dev Cell. 2020 02 10; 52(3):294-308.e3.