Ubiquitin-Protein Ligases

"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Descriptor ID	D044767
MeSH Number(s)	D08.811.464.938.750
Concept/Terms	Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases Ligases, Ubiquitin-Protein Ubiquitin Protein Ligases E3 Ubiquitin Ligase Ligase, E3 Ubiquitin Ubiquitin Ligase, E3 Ubiquitin-Protein Ligase E3 Ligase E3, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ubiquitin Ligase E3 Ligase E3, Ubiquitin Ubiquitin-Protein Ligase Ligase, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ligase Ligase, E3

Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]

Below are MeSH descriptors whose meaning is related to "Ubiquitin-Protein Ligases".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.

Bar chart showing 171 publications over 30 distinct years, with a maximum of 13 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	1	2
1996	1	0	1
1998	0	2	2
1999	1	3	4
2000	0	2	2
2001	2	0	2
2002	4	1	5
2003	1	1	2
2004	3	3	6
2005	1	2	3
2006	1	7	8
2007	1	2	3
2008	3	1	4
2009	3	7	10
2010	6	5	11
2011	4	3	7
2012	6	7	13
2013	5	3	8
2014	6	6	12
2015	0	2	2
2016	4	4	8
2017	4	1	5
2018	3	4	7
2019	6	3	9
2020	5	4	9
2021	4	2	6
2022	3	1	4
2023	1	7	8
2024	4	2	6
2025	1	1	2

Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.

Skorupka KA, Matsuoka K, Hassan B, Ghirlando R, Balachandran V, Chen TH, Walters KJ, Schiffer CA, Wolf M, Iwatani Y, Matsuo H. HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation. Nat Commun. 2025 Jul 01; 16(1):5879.

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Cheng YF, Kempfle JS, Chiang H, Tani K, Wang Q, Chen SH, Lenz D, Chen WY, Wu W, Petrillo M, Edge ASB. Sox2 interacts with Atoh1 and Huwe1 loci to regulate Atoh1 transcription and stability during hair cell differentiation. PLoS Genet. 2025 Jan; 21(1):e1011573.

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Sin YY, Giblin A, Judina A, Rujirachaivej P, Corral LG, Glennon E, Tai ZX, Feng T, Torres E, Zorn A, Gorelik J, Kyurkchieva E, Yenchitsomanus PT, Swindlehurst C, Chan K, Stirling D, Baillie GS. Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS J. 2025 Jul; 292(13):3360-3377.

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Padron A, Dwivedi R, Chakraborty R, Prakash P, Kim K, Shi J, Ahn J, Pandhare J, Luban J, Aiken C, Balasubramaniam M, Dash C. Cyclophilin A facilitates HIV-1 integration. J Virol. 2024 11 19; 98(11):e0094724.

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Simwela NV, Johnston L, Bitar PP, Jaecklein E, Altier C, Sassetti CM, Russell DG. Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth. Nat Commun. 2024 10 29; 15(1):9322.

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Perego M, Yeon M, Agarwal E, Milcarek AT, Bertolini I, Camisaschi C, Ghosh JC, Tang HY, Grandvaux N, Ruscetti M, Kossenkov AV, Preston-Alp S, Tempera I, Auslander N, Altieri DC. Parkin activates innate immunity and promotes antitumor immune responses. J Clin Invest. 2024 Aug 30; 134(22).

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Wang F, Mehta P, Bach I. How does the Xist activator Rlim/Rnf12 regulate Xist expression? Biochem Soc Trans. 2024 06 26; 52(3):1099-1107.

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Parameswaran P, Payne L, Powers J, Rashighi M, Orzalli MH. A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome. J Exp Med. 2024 Aug 05; 221(8).

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Wang F, Chander A, Yoon Y, Welton JM, Wallingford MC, Espejo-Serrano C, Bustos F, Findlay GM, Mager J, Bach I. Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice. Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52):e2313200120.

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Brixi G, Ye T, Hong L, Wang T, Monticello C, Lopez-Barbosa N, Vincoff S, Yudistyra V, Zhao L, Haarer E, Chen T, Pertsemlidis S, Palepu K, Bhat S, Christopher J, Li X, Liu T, Zhang S, Petersen L, DeLisa MP, Chatterjee P. SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders. Commun Biol. 2023 10 24; 6(1):1081.

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