Tumor Suppressor Proteins

"Tumor Suppressor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.

Descriptor ID	D025521
MeSH Number(s)	D12.776.624.776
Concept/Terms	Tumor Suppressor Proteins Tumor Suppressor Proteins Proteins, Tumor Suppressor Metastasis Suppressor Proteins Metastasis Suppressor Proteins Proteins, Metastasis Suppressor Growth Suppressor Proteins Growth Suppressor Proteins Proteins, Growth Suppressor

Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]

Below are MeSH descriptors whose meaning is related to "Tumor Suppressor Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tumor Suppressor Proteins" by people in this website by year, and whether "Tumor Suppressor Proteins" was a major or minor topic of these publications.

Bar chart showing 178 publications over 30 distinct years, with a maximum of 11 publications in 2010 and 2011 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	2	0	2
1998	1	0	1
1999	1	1	2
2000	1	3	4
2001	2	1	3
2002	7	2	9
2003	5	4	9
2004	2	6	8
2005	2	4	6
2006	4	4	8
2007	5	1	6
2008	5	4	9
2009	3	4	7
2010	5	6	11
2011	8	3	11
2012	3	5	8
2013	3	5	8
2014	6	5	11
2015	5	5	10
2016	4	4	8
2017	0	1	1
2018	5	3	8
2019	5	3	8
2020	1	2	3
2021	2	4	6
2023	0	2	2
2024	0	3	3
2025	2	1	3
2026	1	1	2

Below are the most recent publications written about "Tumor Suppressor Proteins" by people in Profiles.

De Silva C, Kelch BA, McCollum D. Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions. PLoS One. 2026; 21(2):e0342107.

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Falc?-Roget J, Basile GA, Janus A, Lillo S, Politi LS, Argasinski JK, Cacciola A. A non-local diffusion magnetic resonance imaging tract density biomarker to stratify, predict, and interpret survival rates in human glioblastoma. Neuro Oncol. 2026 Feb 01; 28(2):564-579.

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Gong W, Taner HF, Wu Y, He Y, Zhou X, Li Z, Hu X, Ursin C, Debnath KC, Okuyama K, Hu Q, Donnelly CR, N?r F, Perera CD, Bellile E, Yunesi A, Zhai Z, Zhao M, Cheng W, Fitzsimonds ZR, Broses L, Li J, Demehri S, Nagrath D, Wolf GT, Sikora AG, Yu Y, Wen H, Wei L, Chinn SB, Myers JN, Akira S, Xie Y, Moon JJ, Lei YL. BATF2 is a glutamine-responsive tumour suppressor required for type-I interferon-dependent anti-tumour immunity. Nat Commun. 2025 Dec 29; 17(1):1271.

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Lynch AC, Hioki KA, Liang X, Thesmar I, Cernjul J, He XD, Mager J, Cui W, Alfandari D, Pobezinskaya EL, Pobezinsky LA. A Dapl1+ subpopulation of na?ve CD8 T cells is enriched for memory-lineage precursors. Sci Adv. 2025 Aug 22; 11(34):eadx5687.

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Abou Nader N, Jakuc N, Meinsohn MC, Charrier L, Banville L, Brind'Amour J, Paquet M, St-Jean G, Boerboom D, Mao J, P?pin D, Breault DT, Zamberlam G, Boyer A. Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex. Endocrinology. 2025 Apr 22; 166(6).

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Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 12; 20(12):8470-8483.

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Ray S, DeSilva C, Dasgupta I, Mana-Capelli S, Cruz-Calderon N, McCollum D. The ability of the LIMD1 and TRIP6 LIM domains to bind strained f-actin is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1. Cytoskeleton (Hoboken). 2024 Sep; 81(9-10):436-447.

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Portela M, Mukherjee S, Paul S, La Marca JE, Parsons LM, Veraksa A, Richardson HE. The Drosophila tumour suppressor Lgl and Vap33 activate the Hippo pathway through a dual mechanism. J Cell Sci. 2024 02 15; 137(4).

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Medeiros MC, The S, Bellile E, Russo N, Schmitd L, Danella E, Singh P, Banerjee R, Bassis C, Murphy GR, Sartor MA, Lombaert I, Schmidt TM, Eisbruch A, Murdoch-Kinch CA, Rozek L, Wolf GT, Li G, Chen GY, D'Silva NJ. Salivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer. Microbiome. 2023 11 30; 11(1):268.

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Kalantzakos T, Hooper K, Das S, Sullivan T, Canes D, Moinzadeh A, Rieger-Christ K. MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells. Int J Mol Sci. 2023 Apr 25; 24(9).

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